The Status of Research: NIH Grant Report, Aug 2016

Aug 2016 Summary | In Aug 2016, NIH awarded $3.11 billion funding in 8,524 grants to 7,080 PIs. California is the most awarded states. UMich is the most awarded institution. Top awarded PIs are Leonidas Platanias from Northwestern, Thomas Lynch from Yale, and Timothy Eberlein from Washington University.

 

Background:

nih_funding_overview_aug_2016

National Institutes of Health (NIH) serves as the nation’s medical research agency and is the largest source of funding for biomedical and behavioral research in the world. The mission of  “The Status of Research” monthly report is to gain insights from multiple perspectives into the entire NIH’s budget composed of as many as 27 appropriations for its Institutes and Centers, Office of the Director, and Buildings and Facilities.

 

Overview

In total, $3.11 billion funding was awarded this month, 18% decrease over July. 7,080 PIs from 920 institutions were awarded 8,524 grants.

nih_funding_state_statistics_aug_2016

Statistics:

The $3.11 billion funding is awarded across 52 states and territories, with funding ranging from $0.93M to $428M. California is the most awarded state with 1,217 projects and 1,026 PIs. Besides California, other top3 awarded states include Massachusetts and New York.

In total, there are 920 institutions received NIH funding, showing a well distributed pattern. UMichigan emerged to first place with 218 projects, 175 PIs, and $70.5M funding. Other top institutions include UPitts and UCSF.

nih_funding_top_pi_state_institution_aug_2016

Each PI received 1.2 Projects with $0.51M funding on average. Among 7,080 awardees, Leonidas Platanias from Northwestern, Thomas Lynch from Yale, and Timothy Eberlein from Washington University are the top 3 most awarded PIs by number of projects.

Closing Remarks

The Status of Research monthly report series was developed to address the lack of a versatile, comprehensive, validated and timely means for in-depth analysis. Our mission is to turn data into actionable insights to make you stay at the forefront of life science and biomedical research. We are hoping to further contribute to the cause of promoting NIH accountability in addition to carrying out its scientific mission.

The Status of Research: NIH Grant Report, July 2016

July 2016 Summary | In July 2016, NIH awarded $3.72 billion funding in 10,379 grants to 8,678 PIs. California is the most awarded states. The UCSF is the most awarded institution. Top awarded PIs are Stephen Emerson, Ronald Depinho, and Max Wicha.

Background:

NIH_Funding_Overview_July_2016

National Institutes of Health (NIH) serves as the nation’s medical research agency and is the largest source of funding for biomedical and behavioral research in the world. The mission of  “The Status of Research” monthly report is to gain insights from multiple perspectives into the entire NIH’s budget composed of as many as 27 appropriations for its Institutes and Centers, Office of the Director, and Buildings and Facilities.

Overview

In total, $3.72 billion funding was awarded this month, 36% increase over June. 8,678 PIs from 858 institutions were awarded 10,379 grants.

 

NIH_Funding_State_Statistics_July_2016Statistics:

The $3.72 billion funding is awarded across 54 states and territories, with funding ranging from $0.33M to $623M. California is the most awarded state with 1,485 projects and 1,200 PIs. Besides California, other top3 awarded states include Massachusetts and New York.

In total, there are 858 institutions received NIH funding, showing a well distributed pattern. UCSF emerged as number 1 place with 301 projects, 212 PIs, and $134M funding. Other top institutions include University of Michigan and University of Pennsylvania.

NIH_Funding_Top_PI_State_Institution_July_2016

Each PI received 1.2 Projects with $0.48M funding on average. Among 8,621 awardees, Stephen Emerson, from Columbia University, Ronald Depinho from MD Anderson, and Max Wicha from University of Michigan are the top 3 most awarded PIs by number of projects.

Closing Remarks

The Status of Research monthly report series was developed to address the lack of a versatile, comprehensive, validated and timely means for in-depth analysis. Our mission is to turn data into actionable insights to make you stay at the forefront of life science and biomedical research. We are hoping to further contribute to the cause of promoting NIH accountability in addition to carrying out its scientific mission.

The Status of Research: NIH Grant Report, June 2016

June 2016 Summary | In June 2016, NIH awarded $2.7 billion funding in 7,030 grants to 6,206 PIs. California is the most awarded states. The Johns Hopkins University is the most awarded institution. Top awarded PIs are Gerson, Stanton; Pestell, Richard; and Holmes, King.

 

Background:

National Institutes of Health (NIH) serves as the nation’s medical research agency and is the largest source of funding for biomedical and behavioral research in the world. The mission of  “The Status of Research” monthly report is to gain insights from multiple perspectives into the entire NIH’s budget composed of as many as 27 appropriations for its Institutes and Centers, Office of the Director, and Buildings and Facilities.

NIH_Funding_Overview_June_2016

Overview

In total, $2.74 billion funding was awarded this month, 3% increase over May, despite the 3% decrease in grant number. 6,206 PIs from 704 institutions were awarded 7,030 grants.

Statistics:

The $2.74 billion funding is awarded across 53 states and territories, with funding ranging from $0.39M to $423.1M. California is the most awarded state with 995 projects and 882 PIs. Besides California, other top3 awarded states include Massachusetts and New York.

NIH_Funding_State_Statistics_June_2016

 

In total, there are 704 institutions received NIH funding, showing a well distributed pattern. The Johns Hopkins University reclaimed its number 1 place with 194 projects, 166 PIs, and $74.7M funding. Other top institutions include University of Pennsylvania and Vanderbilt University.

NIH_Funding_Top_PI_State_Institution_June_2016

Each PI received 1.1 Projects with $0.5M funding on average. Among 6,206 awardees, Gerson, Stanton. from Case Western Reserve University, Pestell, Richard from Thomas Jefferson University, and Holmes, King from University Of Washington are the top 3 most awarded PIs by project number.

Closing Remarks

The Status of Research monthly report series was developed to address the lack of a versatile, comprehensive, validated and timely means for in-depth analysis. Our mission is to turn data into actionable insights to make you stay at the forefront of life science and biomedical research. We are hoping to further contribute to the cause of promoting NIH accountability in addition to carrying out its scientific mission.

The Status of Research: NIH Grant Report, May 2016

MAY 2016 Summary | In May 2016, NIH awarded $2.7 billion funding in 7,334 grants to 6,395 PIs. California is the most awarded states. The Vanderbilt University is the most awarded institution. Top awarded PIs are Donald Trump , Scott Lippman, and Louis Weiner.

Background:

National Institutes of Health (NIH) serves as the nation’s medical research agency and is the largest source of funding for biomedical and behavioral research in the world. The mission of  “The Status of Research” monthly report is to gain insights from multiple perspectives into the entire NIH’s budget composed of as many as 27 appropriations for its Institutes and Centers, Office of the Director, and Buildings and Facilities.

Over_View

Overview

In total, $2.7 billion funding was awarded in May, 17% decrease over April, the major funding cycle. 6,395 PIs from 779 institutions were awarded 7,334 grants.

Statistics:

The $2.7 billion funding is awarded across 52 states and territories, with funding ranging from $0.6M to $369.6M. California is the most awarded state with 988 projects and 852 PIs. Besides California, other top3 awarded states include New York and Massachusetts.

 

State_View

In total, there are 963 institutions received NIH funding, showing a well distributed pattern. Vanderbilt University emerged to be top1 with 358 projects, 268 PIs, and $87M funding. Other top institutions include Washington University and the Johns Hopkins University

Top_View

Each PI received 1.1 Projects with $0.49M funding on average. Among all awardees, Donald Trump from Roswell Park Cancer Institute, Scott Lippman from UCSD and Louis Weiner from Georgetown University are the top 3 most awarded PIs by project number.

 

Closing Remarks

The Status of Research monthly report series was developed to address the lack of a versatile, comprehensive, validated and timely means for in-depth analysis. Our mission is to turn data into actionable insights to make you stay at the forefront of life science and biomedical research. We are hoping to further contribute to the cause of promoting NIH accountability in addition to carrying out its scientific mission.

The Status of Research: NIH Grant Report, April 2016

April 2016 Summary | In April 2016, NIH awarded $3.2 billion funding in 7,475 grants to 6,654 PIs. California is the most awarded states. The Johns Hopkins University is the most awarded institution. Top awarded PIs are LE BEAU MM, CARROLL WL, and WILDING G.

Background:

National Institutes of Health (NIH) serves as the nation’s medical research agency and is the largest source of funding for biomedical and behavioral research in the world. The mission of  “The Status of Research” monthly report is to gain insights from multiple perspectives into the entire NIH’s budget composed of as many as 27 appropriations for its Institutes and Centers, Office of the Director, and Buildings and Facilities.

Overview

Overview

In total, $3.2 billion funding was awarded this month, an increase of 80 percent over March. 6,452 PIs from 739 institutions were awarded 7,475 grants.

Statistics:

The $3.2 billion funding is awarded across 50 states and territories, with funding ranging from $0.6M to $378.2M. California is the most awarded state with 592 projects and 499 PIs. Besides California, other top3 awarded states include Massachusetts and New York.

Distribution

In total, there are 963 institutions received NIH funding, showing a well distributed pattern. The Johns Hopkins University continues to be top1 with 153 projects, 142 PIs, and $60M funding. Other top institutions include UPenn and U Pittsburgh.

 

Top View

Among all awardees, LE BEAU, MM from UChicago, CARROLL, WL from NYU, WILDING G from UWisc Madison are the top 3 most awarded PIs by project number.

Closing Remarks

The Status of Research monthly report series was developed to address the lack of a versatile, comprehensive, validated and timely means for in-depth analysis. Our mission is to turn data into actionable insights to make you stay at the forefront of life science and biomedical research. We are hoping to further contribute to the cause of promoting NIH accountability in addition to carrying out its scientific mission.

Apolipoprotein B: Research Trend, Expert Distribution, and Antibody Citation

Apolipoprotein B, (APOB), also known as FLDB; LDLCQ4; apoB-48; apoB-100, is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [1-6]

Fig 1. APOB Research Distribution. Institutions are ranked by number of related projects.

Research Overview

In the past 16 years, APOB research has been conducted in 207 research groups from 101 institutions in the United States. The accumulated number of projects: 841, and funding: $ 279 million.

Fig 2. Research Trend of APOB by annual NIH project number, funding, and NIH PI.

 

Antibody Citation

APOB accounts for 0.1% of all publications in the past 15 years. 36 manufacturers have produced APOB antibody with citations appearing in peer review publications. The top suppliers are, Roche, Chemicon (now with EMD Millipore), CalBiochem (now with Affymetrix), Sigma-Aldrich, Abcam, and Santa Cruz, accounting for around 50% of total citations. The annual citation trend are summarized below.

 

Fig 3. APOB Antibody Citation breakdown. Total citations from all providers from all years (2000-2014) are included.

Fig 3. APOB Antibody Citation Breakdown. Total citations from all providers from all years (2000-2014) are included.

Fig 4

Fig 4. APOB Antibody Citation Trend: Annual product citation trend from each provider.

 

Closing Remarks:

This snapshot features a quantitative analysis for APOB research, and a cross-vendor comparison for APOB antibody manufacturers. It is aimed to provide a top-down perspective to deepen our understanding for APOB; and an unbiased comparison for rational selection of APOB antibody. The complete list of publications found with APOB antibody citation from major open source publications can be viewed in APOB antibody comparison module.

 

Reference:

  1. Apolipoprotein B, (APOB), Genbank
  2. Genetic polymorphism of APOB is associated with diabetes mellitus in sickle cell disease. Zhang X, et al. Hum Genet, 2015
  3. Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects. Millar JS, et al. J Clin Invest, 2015
  4. Decreased levels of autoantibodies against apolipoprotein B-100 antigens are associated with cardiovascular disease in systemic lupus erythematosus. Svenungsson E, et al. Clin Exp Immunol, 2015
  5. Discordance between apolipoprotein B and low-density lipoprotein particle number is associated with insulin resistance in clinical practice. Varvel SA, et al. J Clin Lipidol, 2015
  6. No association of apolipoprotein B gene polymorphism and blood lipids in obese Egyptian subjects. Bogari NM, et al. J Negat Results Biomed, 2015
  7. A Choline-deficient Diet in Mice Inhibits neither the CDP-choline Pathway for Phosphatidylcholine Synthesis in Hepatocytes nor Apolipoprotein B Secretion. The Journal of Biological Chemistry. 2004
  8. A Gender-specific Role For Phosphatidylethanolamine N-Methyltransferase-derived Phosphatidylcholine in the Regulation of Plasma High Density and Very Low Density Lipoproteins in Mice. The Journal of Biological Chemistry. 2003
  9. A Novel Nontruncating APOB Gene Mutation, R463W, Causes Familial Hypobetalipoproteinemia. The Journal of Biological Chemistry. 2003
  10. A Proteomic Approach Identifies Proteins in Hepatocytes That Bind Nascent Apolipoprotein B. The Journal of Biological Chemistry. 2002
  11. Add-On Effect of Probucol in Atherosclerotic, Cholesterol-Fed Rabbits Treated with Atorvastatin. PLoS ONE. 2014
  12. Advantages and Versatility of Fluorescence-Based Methodology to Characterize the Functionality of LDLR and Class Mutation Assignment. PLoS ONE. 2014
  13. An Unexpected Requirement for PhosphatidylethanolamineN-Methyltransferase in the Secretion of Very Low Density Lipoproteins. The Journal of Biological Chemistry. 2002
  14. ANGPTL3 Decreases Very Low Density Lipoprotein Triglyceride Clearance by Inhibition of Lipoprotein Lipase. The Journal of Biological Chemistry. 2002
  15. ApoA-I Lipidation in Primary Mouse Hepatocytes:SEPARATE CONTROLS FOR PHOSPHOLIPID AND CHOLESTEROL TRANSFERS. The Journal of Biological Chemistry. 2005
  16. Apolipoprotein AV Accelerates Plasma Hydrolysis of Triglyceriderich Lipoproteins by Interaction with Proteoglycan-bound Lipoprotein Lipase. The Journal of Biological Chemistry. 2005
  17. Apolipoprotein B, a Paradigm for Proteins Regulated by Intracellular Degradation, Does Not Undergo Intracellular Degradation in CaCo2 Cells. The Journal of Biological Chemistry. 2000
  18. ApoO, a Novel Apolipoprotein, Is an Original Glycoprotein Up-regulated by Diabetes in Human Heart. The Journal of Biological Chemistry. 2006
  19. Apoprotein B Degradation Is Promoted by the Molecular Chaperones hsp90 and hsp70. The Journal of Biological Chemistry. 2001
  20. Binding of Low Density Lipoproteins to Lipoprotein Lipase Is Dependent on Lipids but Not on Apolipoprotein B. The Journal of Biological Chemistry. 2001
  21. Biochemical and Morphological Properties of Hepatitis C Virus Particles and Determination of Their Lipidome. The Journal of Biological Chemistry. 2011
  22. Cholecystokinin Elevates Mouse Plasma Lipids. PLoS ONE. 2012
  23. Chylomicrons Promote Intestinal Absorption and Systemic Dissemination of Dietary Antigen (Ovalbumin) in Mice. PLoS ONE. 2009
  24. Comparison of Apolipoprotein (apoB/apoA-I) and Lipoprotein (Total Cholesterol/HDL) Ratio Determinants. Focus on Obesity, Diet and Alcohol Intake. PLoS ONE. 2012
  25. Co-translational Interactions of Apoprotein B with the Ribosome and Translocon during Lipoprotein Assembly or Targeting to the Proteasome. The Journal of Biological Chemistry. 2001
  26. Cytoplasmic Lipid Droplets Are Sites of Convergence of Proteasomal and Autophagic Degradation of Apolipoprotein B. Molecular Biology of the Cell. 2006
  27. Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets. Molecular Biology of the Cell. 2012
  28. Derlin-2-Deficient Mice Reveal an Essential Role for Protein Dislocation in Chondrocytes. Molecular and Cellular Biology. 2011
  29. Dietary Squalene Increases High Density Lipoprotein-Cholesterol and Paraoxonase 1 and Decreases Oxidative Stress in Mice. PLoS ONE. 2014
  30. Differential Endocytic Functions ofTrypanosoma brucei Rab5 Isoforms Reveal a Glycosylphosphatidylinositol-specific Endosomal Pathway. The Journal of Biological Chemistry. 2002
  31. Diurnal Regulation of Microsomal Triglyceride Transfer Protein and Plasma Lipid Levels. The Journal of Biological Chemistry. 2007
  32. Expression of Apolipoprotein B in the Kidney Attenuates Renal Lipid Accumulation. The Journal of Biological Chemistry. 2010
  33. Extracellular Matrices of the Avian Ovarian Follicle:MOLECULAR CHARACTERIZATION OF CHICKEN PERLECAN. The Journal of Biological Chemistry. 2004
  34. Ferritins Can Regulate the Secretion of Apolipoprotein B. The Journal of Biological Chemistry. 2003
  35. Foxa1 Reduces Lipid Accumulation in Human Hepatocytes and Is Down-Regulated in Nonalcoholic Fatty Liver. PLoS ONE. 2012
  36. Heparan Sulfate 2-O-Sulfotransferase Is Required for Triglyceride-rich Lipoprotein Clearance. The Journal of Biological Chemistry. 2010
  37. Hepatic CTP:Phosphocholine Cytidylyltransferase-%CE%B1 Is a Critical Predictor of Plasma High Density Lipoprotein and Very Low Density Lipoprotein. The Journal of Biological Chemistry. 2008
  38. Hepatic Very Low Density Lipoprotein-ApoB Overproduction Is Associated with Attenuated Hepatic Insulin Signaling and Overexpression of Protein-tyrosine Phosphatase 1B in a Fructose-fed Hamster Model of Insulin Resistance. The Journal of Biological Chemistry. 2002
  39. Hepatitis C Lipo-Viro-Particle from Chronically Infected Patients Interferes with TLR4 Signaling in Dendritic Cell. PLoS ONE. 2007
  40. Hepatitis C Virus Nonstructural Proteins Inhibit Apolipoprotein B100 Secretion. The Journal of Biological Chemistry. 2005
  41. Hepatitis C Virus Proteins Induce Lipogenesis and Defective Triglyceride Secretion in Transgenic Mice. The Journal of Biological Chemistry. 2009
  42. Human Placenta Secretes Apolipoprotein B-100-containing Lipoproteins. The Journal of Biological Chemistry. 2004
  43. Hypobetalipoproteinemic Mice with a Targeted Apolipoprotein (Apo) B-27.6-specifying Mutation:%0AIN VIVO EVIDENCE FOR AN IMPORTANT ROLE OF AMINO ACIDS 1254%E2%80%931744 OF ApoB IN LIPID TRANSPORT AND METABOLISM OF THE ApoB-CONTAINING LIPOPROTEIN%0A. The Journal of Biological Chemistry. 2002
  44. Identification of the Lipoprotein Initiating Domain of Apolipoprotein B. The Journal of Biological Chemistry. 2003
  45. Identification of the Proteoglycan Binding Site in Apolipoprotein B48. The Journal of Biological Chemistry. 2002
  46. Impact of Glutathione Peroxidase-1 Deficiency on Macrophage Foam Cell Formation and Proliferation: Implications for Atherogenesis. PLoS ONE. 2013
  47. Increased Tau Phosphorylation and Impaired Presynaptic Function in Hypertriglyceridemic ApoB-100 Transgenic Mice. PLoS ONE. 2012
  48. Inhibiting Proteasomal Degradation of Microsomal Triglyceride Transfer Protein Prevents CCl4-induced Steatosis. The Journal of Biological Chemistry. 2007
  49. Inhibition of Translocation of Nascent Apolipoprotein B across the Endoplasmic Reticulum Membrane Is Associated with Selective Inhibition of the Synthesis of Apolipoprotein B. The Journal of Biological Chemistry. 2000
  50. Internalization of Transthyretin:EVIDENCE OF A NOVEL YET UNIDENTIFIED RECEPTOR-ASSOCIATED PROTEIN (RAP)-SENSITIVE RECEPTOR. The Journal of Biological Chemistry. 2001
  51. Iron loading impairs lipoprotein lipase activity and promotes hypertriglyceridemia. The FASEB Journal. 2013
  52. Isozyme-nonselective N-Substituted Bipiperidylcarboxamide Acetyl-CoA Carboxylase Inhibitors Reduce Tissue Malonyl-CoA Concentrations, Inhibit Fatty Acid Synthesis, and Increase Fatty Acid Oxidation in Cultured Cells and in Experimental Animals. The Journal of Biological Chemistry. 2003
  53. Lipid-dependent Bidirectional Traffic of Apolipoprotein B in Polarized Enterocytes. Molecular Biology of the Cell. 2004
  54. Lipoprotein Lipase (LPL) Strongly Links Native and Oxidized Low Density Lipoprotein Particles to Decorin-coated Collagen:ROLES FOR BOTH DIMERIC AND MONOMERIC FORMS OF LPL. The Journal of Biological Chemistry. 2000
  55. Liver-specific Deficiency of Serine Palmitoyltransferase Subunit 2 Decreases Plasma Sphingomyelin and Increases Apolipoprotein E Levels. The Journal of Biological Chemistry. 2009
  56. Long Chain Acyl-CoA Synthetase 3-mediated Phosphatidylcholine Synthesis Is Required for Assembly of Very Low Density Lipoproteins in Human Hepatoma Huh7 Cells. The Journal of Biological Chemistry. 2008
  57. Luminal Lipid Regulates CD36 Levels and Downstream Signaling to Stimulate Chylomicron Synthesis. The Journal of Biological Chemistry. 2011
  58. Lysophosphatidylcholine Acyltransferase 3 Knockdown-mediated Liver Lysophosphatidylcholine Accumulation Promotes Very Low Density Lipoprotein Production by Enhancing Microsomal Triglyceride Transfer Protein Expression. The Journal of Biological Chemistry. 2012
  59. Macrophage-Specific ApoE Gene Repair Reduces Diet-Induced Hyperlipidemia and Atherosclerosis in Hypomorphic Apoe Mice. PLoS ONE. 2012
  60. Mechanisms of Hepatic Very Low Density Lipoprotein Overproduction in Insulin Resistance:EVIDENCE FOR ENHANCED LIPOPROTEIN ASSEMBLY, REDUCED INTRACELLULAR ApoB DEGRADATION, AND INCREASED MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN IN A FRUCTOSE-FED HAMSTER MODEL. The Journal of Biological Chemistry. 2000
  61. Metformin Prevents and Reverses Inflammation in a Non-Diabetic Mouse Model of Nonalcoholic Steatohepatitis. PLoS ONE. 2012
  62. Microsomal Triacylglycerol Transfer Protein Is Required for Lumenal Accretion of Triacylglycerol Not Associated with ApoB, as Well as for ApoB Lipidation. The Journal of Biological Chemistry. 2002
  63. Microsomal Triglyceride Transfer Protein Binding and Lipid Transfer Activities Are Independent of Each Other, but Both Are Required for Secretion of Apolipoprotein B Lipoproteins from Liver Cells. The Journal of Biological Chemistry. 2001
  64. Missense Mutations in APOB within the %CE%B2%CE%B11 Domain of Human APOB-100 Result in Impaired Secretion of ApoB and ApoB-containing Lipoproteins in Familial Hypobetalipoproteinemia. The Journal of Biological Chemistry. 2007
  65. Morphological Characterization and Fusion Properties of Triglyceride-rich Lipoproteins Obtained from Cells Transduced with Hepatitis C Virus Glycoproteins. The Journal of Biological Chemistry. 2010
  66. Nascent Lipidated Apolipoprotein B Is Transported to the Golgi as an Incompletely Folded Intermediate as Probed by Its Association with Network of Endoplasmic Reticulum Molecular Chaperones, GRP94, ERp72, BiP, Calreticulin, and Cyclophilin B. The Journal of Biological Chemistry. 2003
  67. NF%CE%BAB Regulates Plasma Apolipoprotein A-I and High Density Lipoprotein Cholesterol through Inhibition of Peroxisome Proliferator-activated Receptor %CE%B1. The Journal of Biological Chemistry. 2003
  68. Overexpression of Lipoprotein Lipase in Transgenic Rabbits Inhibits Diet-induced Hypercholesterolemia and Atherosclerosis. The Journal of Biological Chemistry. 2001
  69. Overexpression of the Tumor Autocrine Motility Factor Receptor Gp78, a Ubiquitin Protein Ligase, Results in Increased Ubiquitinylation and Decreased Secretion of Apolipoprotein B100 in HepG2 Cells. The Journal of Biological Chemistry. 2003
  70. Oxidized Low Density Lipoprotein Activates Peroxisome Proliferator-activated Receptor-%CE%B1 (PPAR%CE%B1) and PPAR%CE%B3 through MAPK-dependent COX-2 Expression in Macrophages. The Journal of Biological Chemistry. 2008
  71. Pharmacologic Inhibition of Sphingomyelin Synthase (SMS) Activity Reduces Apolipoprotein-B Secretion from Hepatocytes and Attenuates Endotoxin-Mediated Macrophage Inflammation. PLoS ONE. 2014
  72. Proteomic Analysis of Lipid Droplets from Caco-2/TC7 Enterocytes Identifies Novel Modulators of Lipid Secretion. PLoS ONE. 2013
  73. Proteomic Analysis of Lipid Droplets from Caco-2/TC7 Enterocytes Identifies Novel Modulators of Lipid Secretion. PLoS ONE. 2012
  74. Proteomic and Lipid Characterization of Apolipoprotein B-free Luminal Lipid Droplets from Mouse Liver Microsomes:IMPLICATIONS FOR VERY LOW DENSITY LIPOPROTEIN ASSEMBLY. The Journal of Biological Chemistry. 2007
  75. Reduced Apolipoprotein Glycosylation in Patients with the Metabolic Syndrome. PLoS ONE. 2014
  76. Regulation of ApoB Secretion by the Low Density Lipoprotein Receptor Requires Exit from the Endoplasmic Reticulum and Interaction with ApoE or ApoB. The Journal of Biological Chemistry. 2008
  77. Secreted Progranulin Is a Homodimer and Is Not a Component of High Density Lipoproteins (HDL). The Journal of Biological Chemistry. 2013
  78. Secretion of Hepatitis C Virus Envelope Glycoproteins Depends on Assembly of Apolipoprotein B Positive Lipoproteins. PLoS ONE. 2009
  79. Stimulation of Lipogenesis by Pharmacological Activation of the Liver X Receptor Leads to Production of Large, Triglyceride-rich Very Low Density Lipoprotein Particles. The Journal of Biological Chemistry. 2002
  80. Targeted Deletion of Hepatic CTP:phosphocholine Cytidylyltransferase %CE%B1 in Mice Decreases Plasma High Density and Very Low Density Lipoproteins. The Journal of Biological Chemistry. 2004
  81. The Amino-terminal Domain of Apolipoprotein B Does Not Undergo Retrograde Translocation from the Endoplasmic Reticulum to the Cytosol:PROTEASOMAL DEGRADATION OF NASCENT APOLIPOPROTEIN B BEGINS AT THE CARBOXYL TERMINUS OF THE PROTEIN, WHILE APOLIPOPROTEIN B IS STILL IN ITS ORIGINAL TRANSLOCON. The Journal of Biological Chemistry. 2000
  82. The Hepatitis B Virus X Protein Inhibits Secretion of Apolipoprotein B by Enhancing the Expression of N-Acetylglucosaminyltransferase III. The Journal of Biological Chemistry. 2004
  83. The Hsp110 Molecular Chaperone Stabilizes Apolipoprotein B from Endoplasmic Reticulum-associated Degradation (ERAD). The Journal of Biological Chemistry. 2007
  84. The Lipidation by Hepatocytes of Human Apolipoprotein A-I Occurs by Both ABCA1-dependent and -independent Pathways. The Journal of Biological Chemistry. 2003
  85. The Triple Threat to Nascent Apolipoprotein B:EVIDENCE FOR MULTIPLE, DISTINCT DEGRADATIVE PATHWAYS. The Journal of Biological Chemistry. 2001
  86. Transmembrane Lipid Transfer Is Crucial for Providing Neutral Lipids during Very Low Density Lipoprotein Assembly in Endoplasmic Reticulum. The Journal of Biological Chemistry. 2003
  87. Tumor Necrosis Factor-%CE%B1 and Interleukin-1%CE%B2 Inhibit Apolipoprotein B Secretion in CaCo-2 Cells via the Epidermal Growth Factor Receptor Signaling Pathway. The Journal of Biological Chemistry. 2000
  88. Up-Regulation of the ATP-Binding Cassette Transporter A1 Inhibits Hepatitis C Virus Infection. PLoS ONE. 2014

ERBB2: Research Trend, Expert Distribution, and Antibody Citation

Erb-b2 receptor tyrosine kinase 2, (ERBB2), also known as NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu, is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [1-6]

Fig 1. ERBB2 Research Distribution. Institutions are ranked by number of related projects.

Fig 1. ERBB2 Research Distribution. Institutions are ranked by number of related projects.

Research Overview

In the past 16 years, ERBB2 research has been conducted in 1,005 research groups from 296 institutions in the United States. The accumulated number of projects: 3,686, and funding: $ 1.1 billion.

 

Fig 2. Research Trend of ERBB2 by annual NIH project number, funding, and NIH PI.

Fig 2. Research Trend of ERBB2 by annual NIH project number, funding, and NIH PI.

Antibody Citation

ERBB2 accounts for 0.3% of all publications in the past 15 years. 53 manufacturers have produced ERBB2 antibody with citations appearing in peer review publications. The top suppliers are, Santa Cruz, Cell Signaling Technology, NeoMarkers (now with Thermo Scientific), Dako, and Upstate (now with EMD Millipore)accounting for around 60% of total citations. The annual citation trend are summarized below.

 

Fig 3. ERBB2 Antibody Citation breakdown. Total citations from all providers from all years (2000-2014) are included.

Fig 3. ERBB2 Antibody Citation breakdown. Total citations from all providers from all years (2000-2014) are included.

Fig 4

Fig 4. ERBB2 Antibody Citation Trend: Annual product citation trend from each provider.

 

Closing Remarks:

This snapshot features a quantitative analysis for ERBB2 research, and a cross-vendor comparison for ERBB2 antibody manufacturers. It is aimed to provide a top-down perspective to deepen our understanding for ERBB2; and an unbiased comparison for rational selection of ERBB2 antibody. The complete list of publications found with ERBB2 antibody citation from major open source publications can be viewed in ERBB2 antibody comparison module.

 

Reference:

  1. Erb-b2 receptor tyrosine kinase 2, (ERBB2), Genbank
  2. Molecular effects of Lapatinib in the treatment of HER2 overexpressing oesophago-gastric adenocarcinoma. De Silva N, et al. Br J Cancer, 2015
  3. Brain metastases in gastro-oesophageal adenocarcinoma: insights into the role of the human epidermal growth factor receptor 2 (HER2). Feilchenfeldt J, et al. Br J Cancer, 2015
  4. Are neutrophil/lymphocyte ratio and platelet/lymphocyte ratio associated with prognosis in patients with HER2-positive early breast cancer receiving adjuvant trastuzumab? Ulas A, et al. J BUON, 2015
  5. Is Helicobacter Pylori associated with Her2/neu Overexpression in Gastric Cancer Patients who Underwent Curative Resection? Yoo MW, et al. Hepatogastroenterology, 2014
  6. CORRELATION BETWEEN C-erbB-2 WITH GASTRIC MUCOSAL ATYPICAL HYPERPLASIA AND GASTRIC CARCINOMA. Song B, et al. J Biol Regul Homeost Agents, 2015
  7. [18F]-Fluorodeoxyglucose Positron Emission Tomography Can Contribute to Discriminate Patients with Poor Prognosis in Hormone Receptor-Positive Breast Cancer. PLoS ONE. 2014
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  208. Novel Role for Cyclin-dependent Kinase 2 in Neuregulin-induced Acetylcholine Receptor %CF%B5 Subunit Expression in Differentiated Myotubes. The Journal of Biological Chemistry. 2005
  209. Nuclear Expression of KLF6 Tumor Suppressor Factor Is Highly Associated with Overexpression of ERBB2 Oncoprotein in Ductal Breast Carcinomas. PLoS ONE. 2010
  210. Nuclear Translocation of Type I Transforming Growth Factor %CE%B2 Receptor Confers a Novel Function in RNA Processing. Molecular and Cellular Biology. 2012
  211. OFD1 and Flotillins Are Integral Components of a Ciliary Signaling Protein Complex Organized by Polycystins in Renal Epithelia and Odontoblasts. PLoS ONE. 2014
  212. Oligomers of ERBB3 Have Two Distinct Interfaces That Differ in Their Sensitivity to Disruption by Heregulin. The Journal of Biological Chemistry. 2005
  213. One-Step Preservation of Phosphoproteins and Tissue Morphology at Room Temperature for Diagnostic and Research Specimens. PLoS ONE. 2011
  214. Overexpression of HER2 (erbB2) in Human Breast Epithelial Cells Unmasks Transforming Growth Factor %CE%B2-induced Cell Motility. The Journal of Biological Chemistry. 2004
  215. P130Cas Attenuates Epidermal Growth Factor (EGF) Receptor Internalization by Modulating EGF-Triggered Dynamin Phosphorylation. PLoS ONE. 2011
  216. Paclitaxel-Induced Apoptosis Is BAK-Dependent, but BAX and BIM-Independent in Breast Tumor. PLoS ONE. 2013
  217. Pam and Its Ortholog Highwire Interact with and May Negatively Regulate the TSC1%C2%B7TSC2 Complex. The Journal of Biological Chemistry. 2004
  218. Parsing ERK Activation Reveals Quantitatively Equivalent Contributions from Epidermal Growth Factor Receptor and HER2 in Human Mammary Epithelial Cells. The Journal of Biological Chemistry. 2005
  219. PEA3 Transactivates the Muc4/Sialomucin Complex Promoter in Mammary Epithelial and Tumor Cells. The Journal of Biological Chemistry. 2003
  220. Phosphodiesterase Type 5 Inhibitors Increase Herceptin Transport and Treatment Efficacy in Mouse Metastatic Brain Tumor Models. PLoS ONE. 2010
  221. Phosphoinositide 3-Kinase Pathway Activation in Phosphate and Tensin Homolog (PTEN)-deficient Prostate Cancer Cells Is Independent of Receptor Tyrosine Kinases and Mediated by the p110%CE%B2 and p110%CE%B4 Catalytic Subunits. The Journal of Biological Chemistry. 2010
  222. pH-Responsive Artemisinin Derivatives and Lipid Nanoparticle Formulations Inhibit Growth of Breast Cancer Cells In Vitro and Induce Down-Regulation of HER Family Members. PLoS ONE. 2013
  223. Physical Basis behind Achondroplasia, the Most Common Form of Human Dwarfism. The Journal of Biological Chemistry. 2010
  224. Plasma Membrane Proteomics of Human Breast Cancer Cell Lines Identifies Potential Targets for Breast Cancer Diagnosis and Treatment. PLoS ONE. 2014
  225. Postoperative Fever: The Potential Relationship with Prognosis in Node Negative Breast Cancer Patients. PLoS ONE. 2010
  226. Post-Transcriptional Regulation of Connexin43 in H-Ras-Transformed Cells. PLoS ONE. 2013
  227. Potent regulation of microglia-derived oxidative stress and dopaminergic neuron survival: substance P vs. dynorphin. The FASEB Journal. 2006
  228. Preclinical screening of anti-HER2 nanobodies for molecular imaging of breast cancer. The FASEB Journal. 2011
  229. Presence of CHD1L Over-Expression Is Associated with Aggressive Tumor Biology and Is a Novel Prognostic Biomarker for Patient Survival in Human Breast Cancer. PLoS ONE. 2014
  230. Pretreatment of Acetylsalicylic Acid Promotes Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis by Down-regulating BCL-2 Gene Expression. The Journal of Biological Chemistry. 2005
  231. Profiling the HER3/PI3K Pathway in Breast Tumors Using Proximity-Directed Assays Identifies Correlations between Protein Complexes and Phosphoproteins. PLoS ONE. 2011
  232. Progesterone Receptor Induces ErbB-2 Nuclear Translocation To Promote Breast Cancer Growth via a Novel Transcriptional Effect: ErbB-2 Function as a Coactivator of Stat3. Molecular and Cellular Biology. 2010
  233. Prognostic and Predictive Significance of MYC and KRAS Alterations in Breast Cancer from Women Treated with Neoadjuvant Chemotherapy. PLoS ONE. 2013
  234. Prognostic Influence of Pre-Operative C-Reactive Protein in Node-Negative Breast Cancer Patients. PLoS ONE. 2014
  235. Proliferation of Colorectal Cancer Is Promoted by Two Signaling Transduction Expression Patterns: ErbB2/ErbB3/AKT and MET/ErbB3/MAPK. PLoS ONE. 2013
  236. Propionyl-Coenzyme A Synthase from Chloroflexus aurantiacus, a Key Enzyme of the 3-Hydroxypropionate Cycle for Autotrophic CO2 Fixation. The Journal of Biological Chemistry. 2002
  237. Protein Kinase A-mediated Gating of Neuregulin-dependent ErbB2-ErbB3 Activation Underlies the Synergistic Action of cAMP on Schwann Cell Proliferation. The Journal of Biological Chemistry. 2008
  238. Protein-tyrosine Kinase 6 Promotes Peripheral Adhesion Complex Formation and Cell Migration by Phosphorylating p130 CRK-associated Substrate. The Journal of Biological Chemistry. 2012
  239. Protein-tyrosine Phosphatase %CF%B5 Regulates Shc Signaling in a Kinase-specific Manner:INCREASING COHERENCE IN TYROSINE PHOSPHATASE SIGNALING. The Journal of Biological Chemistry. 2008
  240. Protein-tyrosine Phosphatase PTPN9 Negatively Regulates ErbB2 and Epidermal Growth Factor Receptor Signaling in Breast Cancer Cells. The Journal of Biological Chemistry. 2010
  241. Proteomic Analyses Reveal High Expression of Decorin and Endoplasmin (HSP90B1) Are Associated with Breast Cancer Metastasis and Decreased Survival. PLoS ONE. 2012
  242. PTEN Deficiency in a Luminal ErbB-2 Mouse Model Results in Dramatic Acceleration of Mammary Tumorigenesis and Metastasis. The Journal of Biological Chemistry. 2009
  243. PTIP Associated protein 1, PA1, Is an Independent Prognostic Factor for Lymphnode Negative Breast Cancer. PLoS ONE. 2013
  244. Quantitative Transcriptional Control of ErbB Receptor Signaling Undergoes Graded to Biphasic Response for Cell Differentiation. The Journal of Biological Chemistry. 2007
  245. RB1CC1 Together with RB1 and p53 Predicts Long-Term Survival in Japanese Breast Cancer Patients. PLoS ONE. 2010
  246. Reciprocal Regulation of Annexin A2 and EGFR with Her-2 in Her-2 Negative and Herceptin-Resistant Breast Cancer. PLoS ONE. 2012
  247. Reduced amount of the glucose-regulated protein GRP94 in skeletal myoblasts results in loss of fusion competence. The FASEB Journal. 2000
  248. Regulation of Epidermal Growth Factor Receptor Signaling by Endocytosis and Intracellular Trafficking. Molecular Biology of the Cell. 2001
  249. Regulation of ErbB2 Receptor Status by the Proteasomal DUB POH1. PLoS ONE. 2009
  250. Regulation of Heparin-Binding EGF-Like Growth Factor by miR-212 and Acquired Cetuximab-Resistance in Head and Neck Squamous Cell Carcinoma. PLoS ONE. 2010
  251. Regulation of MDR1 Expression and Drug Resistance by a Positive Feedback Loop Involving Hyaluronan, Phosphoinositide 3-Kinase, and ErbB2. The Journal of Biological Chemistry. 2005
  252. Reorganization of ErbB Family and Cell Survival Signaling after Knock-down of ErbB2 in Colon Cancer Cells. The Journal of Biological Chemistry. 2005
  253. Respective Prognostic Value of Genomic Grade and Histological Proliferation Markers in Early Stage (pN0) Breast Carcinoma. PLoS ONE. 2012
  254. RGS16 Inhibits Breast Cancer Cell Growth by Mitigating Phosphatidylinositol 3-Kinase Signaling. The Journal of Biological Chemistry. 2009
  255. RNA Interference Screen Identifies Usp18 as a Regulator of Epidermal Growth Factor Receptor Synthesis. Molecular Biology of the Cell. 2009
  256. Role of IGF-Binding Protein 3 in the Resistance of EGFR Mutant Lung Cancer Cells to EGFR-Tyrosine Kinase Inhibitors. PLoS ONE. 2013
  257. Role of Neuregulin-1/ErbB2 Signaling in Endothelium-Cardiomyocyte Cross-talk. The Journal of Biological Chemistry. 2006
  258. Roles and Mechanism of miR-199a and miR-125b in Tumor Angiogenesis. PLoS ONE. 2013
  259. Rotational Coupling of the Transmembrane and Kinase Domains of the Neu Receptor Tyrosine Kinase. Molecular Biology of the Cell. 2000
  260. Schwann Cell Dedifferentiation Is Independent of Mitogenic Signaling and Uncoupled to Proliferation:ROLE OF cAMP AND JNK IN THE MAINTENANCE OF THE DIFFERENTIATED STATE. The Journal of Biological Chemistry. 2010
  261. Secreted Heat Shock Protein 90%CE%B1 Induces Colorectal Cancer Cell Invasion through CD91/LRP-1 and NF-%CE%BAB-mediated Integrin %CE%B1V Expression. The Journal of Biological Chemistry. 2010
  262. Sequence-specific Peptide Aptamers, Interacting with the Intracellular Domain of the Epidermal Growth Factor Receptor, Interfere with Stat3 Activation and Inhibit the Growth of Tumor Cells. The Journal of Biological Chemistry. 2003
  263. Serum HER 2 Extracellular Domain Level Is Correlated with Tissue HER 2 Status in Metastatic Gastric or Gastro-Oesophageal Junction Adenocarcinoma. PLoS ONE. 2013
  264. Signaling Cascades Activated upon Antibody Cross-linking of Myelin Oligodendrocyte Glycoprotein:POTENTIAL IMPLICATIONS FOR MULTIPLE SCLEROSIS. The Journal of Biological Chemistry. 2005
  265. Significance of Heterogeneous Twist2 Expression in Human Breast Cancers. PLoS ONE. 2012
  266. Silencing of ErbB3/ErbB2 Signaling by Immunoglobulin-like Necl-2. The Journal of Biological Chemistry. 2009
  267. Similar Prognoses for Invasive Micropapillary Breast Carcinoma and Pure Invasive Ductal Carcinoma: A Retrospectively Matched Cohort Study in China. PLoS ONE. 2014
  268. Small Molecule ErbB Inhibitors Decrease Proliferative Signaling and Promote Apoptosis in Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia. PLoS ONE. 2013
  269. Somatic Mutations of ErbB4:SELECTIVE LOSS-OF-FUNCTION PHENOTYPE AFFECTING SIGNAL TRANSDUCTION PATHWAYS IN CANCER. The Journal of Biological Chemistry. 2009
  270. Specific Structural Features of Heparan Sulfate Proteoglycans Potentiate Neuregulin-1 Signaling. The Journal of Biological Chemistry. 2005
  271. Spectrum of EGFR Gene Copy Number Changes and KRAS Gene Mutation Status in Korean Triple Negative Breast Cancer Patients. PLoS ONE. 2013
  272. Sphingosine Kinase 1 Induces Tolerance to Human Epidermal Growth Factor Receptor 2 and Prevents Formation of a Migratory Phenotype in Response to Sphingosine 1-Phosphate in Estrogen Receptor-Positive Breast Cancer Cells. Molecular and Cellular Biology. 2010
  273. Src Mutation Induces Acquired Lapatinib Resistance in ERBB2-Amplified Human Gastroesophageal Adenocarcinoma Models. PLoS ONE. 2014
  274. ?1 Integrin Binding Phosphorylates Ezrin at T567 to Activate a Lipid Raft Signalsome Driving Invadopodia Activity and Invasion. PLoS ONE. 2013
  275. STED Super-Resolution Microscopy of Clinical Paraffin-Embedded Human Rectal Cancer Tissue. PLoS ONE. 2014
  276. Structural Insights into the Down-regulation of Overexpressed p185her2/neu Protein of Transformed Cells by the Antibody chA21. The Journal of Biological Chemistry. 2011
  277. Suppression of Heregulin %CE%B2 Signaling by the Single N-Glycan Deletion Mutant of Soluble ErbB3 Protein. The Journal of Biological Chemistry. 2013
  278. t10c12 Conjugated Linoleic Acid Suppresses HER2 Protein and Enhances Apoptosis in SKBr3 Breast Cancer Cells: Possible Role of COX2. PLoS ONE. 2009
  279. Targeting Human Epidermal Growth Factor Receptor Signaling with the Neuregulin’s Heparin-binding Domain. The Journal of Biological Chemistry. 2009
  280. The Alternative Splice Variant of Protein Tyrosine Kinase 6 Negatively Regulates Growth and Enhances PTK6-Mediated Inhibition of β-Catenin. PLoS ONE. 2010
  281. The Aqueous Extract of Ficus religiosa Induces Cell Cycle Arrest in Human Cervical Cancer Cell Lines SiHa (HPV-16 Positive) and Apoptosis in HeLa (HPV-18 Positive). PLoS ONE. 2013
  282. The Cooperation between hMena Overexpression and HER2 Signalling in Breast Cancer. PLoS ONE. 2010
  283. The E3 Ubiquitin Ligase WWP1 Selectively Targets HER4 and Its Proteolytically Derived Signaling Isoforms for Degradation. Molecular and Cellular Biology. 2009
  284. The Effect of Antineoplastic Drugs in a Male Spontaneous Mammary Tumor Model. PLoS ONE. 2013
  285. The Endocannabinoid Anandamide Inhibits Neuronal Progenitor Cell Differentiation through Attenuation of the Rap1/B-Raf/ERK Pathway. The Journal of Biological Chemistry. 2002
  286. The Erbin PDZ Domain Binds with High Affinity and Specificity to the Carboxyl Termini of %CE%B4-Catenin and ARVCF. The Journal of Biological Chemistry. 2002
  287. The Extracellular Linker of pro-Neuregulin-α2c Is Required for Efficient Sorting and Juxtacrine Function. Molecular Biology of the Cell. 2007
  288. The HER2-Binding Affibody Molecule (ZHER2∶342)2 Increases Radiosensitivity in SKBR-3 Cells. PLoS ONE. 2012
  289. The HER2-Encoded miR-4728-3p Regulates ESR1 through a Non-Canonical Internal Seed Interaction. PLoS ONE. 2014
  290. The HSP90 Inhibitor NVP-AUY922 Radiosensitizes by Abrogation of Homologous Recombination Resulting in Mitotic Entry with Unresolved DNA Damage. PLoS ONE. 2012
  291. The Human Splice Variant Δ16HER2 Induces Rapid Tumor Onset in a Reporter Transgenic Mouse. PLoS ONE. 2011
  292. The Intracellular Domain of ErbB4 Induces Differentiation of Mammary Epithelial Cells. Molecular Biology of the Cell. 2006
  293. The Marine-Derived Oligosaccharide Sulfate (MdOS), a Novel Multiple Tyrosine Kinase Inhibitor, Combats Tumor Angiogenesis both In Vitro and In Vivo. PLoS ONE. 2008
  294. The Mucin MUC4 and Its Membrane Partner ErbB2 Regulate Biological Properties of Human CAPAN-2 Pancreatic Cancer Cells via Different Signalling Pathways. PLoS ONE. 2012
  295. The Mucin Muc4 Potentiates Neuregulin Signaling by Increasing the Cell-surface Populations of ErbB2 and ErbB3. The Journal of Biological Chemistry. 2006
  296. The Neurofibromatosis 2 Protein, Merlin, Regulates Glial Cell Growth in an ErbB2- and Src-Dependent Manner. Molecular and Cellular Biology. 2009
  297. The N-terminal Domains of Neuregulin 1 Confer Signal Attenuation. The Journal of Biological Chemistry. 2006
  298. The Prolyl Isomerase Pin1 Induces LC-3 Expression and Mediates Tamoxifen Resistance in Breast Cancer. The Journal of Biological Chemistry. 2010
  299. The Relative Expression of Mig6 and EGFR Is Associated with Resistance to EGFR Kinase Inhibitors. PLoS ONE. 2013
  300. Theranostic Protein Targeting ErbB2 for Bioluminescence Imaging and Therapy for Cancer. PLoS ONE. 2013
  301. Time-resolved Fluorescence Resonance Energy Transfer (TR-FRET) to Analyze the Disruption of EGFR/HER2 Dimers:A NEW METHOD TO EVALUATE THE EFFICIENCY OF TARGETED THERAPY USING MONOCLONAL ANTIBODIES. The Journal of Biological Chemistry. 2011
  302. Transactivation of ErbB2 and ErbB3 by Tumor Necrosis Factor-%CE%B1 and Anisomycin Leads to Impaired Insulin Signaling through Serine/Threonine Phosphorylation of IRS Proteins. The Journal of Biological Chemistry. 2002
  303. Transautocrine Signaling by Membrane Neuregulins Requires Cell Surface Targeting, Which Is Controlled by Multiple Domains. The Journal of Biological Chemistry. 2011
  304. Transcription Factor AP-2%CE%B1 Is Preferentially Cleaved by Caspase 6 and Degraded by Proteasome during Tumor Necrosis Factor Alpha-Induced Apoptosis in Breast Cancer Cells. Molecular and Cellular Biology. 2001
  305. Transcriptional Control of Cholesterol Biosynthesis in Schwann Cells by Axonal Neuregulin 1. The Journal of Biological Chemistry. 2007
  306. Transforming Growth Factor %CE%B2 Engages TACE and ErbB3 To Activate Phosphatidylinositol-3 Kinase/Akt in ErbB2-Overexpressing Breast Cancer and Desensitizes Cells to Trastuzumab. Molecular and Cellular Biology. 2008
  307. Transforming Growth Factor Alpha (TGFα) Regulates Granulosa Cell Tumor (GCT) Cell Proliferation and Migration through Activation of Multiple Pathways. PLoS ONE. 2012
  308. Transgenic MUC1 Interacts with Epidermal Growth Factor Receptor and Correlates with Mitogen-activated Protein Kinase Activation in the Mouse Mammary Gland. The Journal of Biological Chemistry. 2001
  309. Transmembrane Peptides as Inhibitors of ErbB Receptor Signaling. Molecular Biology of the Cell. 2004
  310. Trastuzumab Mediated T-Cell Response against HER-2/Neu Overexpressing Esophageal Adenocarcinoma Depends on Intact Antigen Processing Machinery. PLoS ONE. 2010
  311. TTK/hMPS1 Is an Attractive Therapeutic Target for Triple-Negative Breast Cancer. PLoS ONE. 2013
  312. Tumor Cell Plasticity and Angiogenesis in Human Melanomas. PLoS ONE. 2012
  313. Tumor Selective Cytotoxic Action of a Thiomorpholin Hydroxamate Inhibitor (TMI-1) in Breast Cancer. PLoS ONE. 2012
  314. Tumor-Infiltrating T Cells Correlate with NY-ESO-1-Specific Autoantibodies in Ovarian Cancer. PLoS ONE. 2008
  315. Unique MicroRNA Profile in End-stage Heart Failure Indicates Alterations in Specific Cardiovascular Signaling Networks. The Journal of Biological Chemistry. 2009
  316. Up-regulation of Acetyl-CoA Carboxylase %CE%B1 and Fatty Acid Synthase by Human Epidermal Growth Factor Receptor 2 at the Translational Level in Breast Cancer Cells. The Journal of Biological Chemistry. 2007
  317. Up-Regulation of Kin17 Is Essential for Proliferation of Breast Cancer. PLoS ONE. 2011
  318. Up-regulation of miR-21 by HER2/neu Signaling Promotes Cell Invasion. The Journal of Biological Chemistry. 2009
  319. Upregulation of the Catalytic Telomerase Subunit by the Transcription Factor ER81 and Oncogenic HER2/Neu, Ras, or Raf. Molecular and Cellular Biology. 2004
  320. Up-regulation of Vascular Endothelial Growth Factor C in Breast Cancer Cells by Heregulin-%CE%B21:A CRITICAL ROLE OF p38/NUCLEAR FACTOR-%CE%BAB SIGNALING PATHWAY. The Journal of Biological Chemistry. 2003
  321. UTP Transactivates Epidermal Growth Factor Receptors and Promotes Cardiomyocyte Hypertrophy Despite Inhibiting Transcription of the Hypertrophic Marker Gene, Atrial Natriuretic Peptide. The Journal of Biological Chemistry. 2004
  322. V3 Versican Isoform Alters the Behavior of Human Melanoma Cells by Interfering with CD44/ErbB-dependent Signaling. The Journal of Biological Chemistry. 2011
  323. Vertebrate Lrig3-ErbB Interactions Occur In Vitro but Are Unlikely to Play a Role in Lrig3-Dependent Inner Ear Morphogenesis. PLoS ONE. 2010
  324. VRK2 Inhibits Mitogen-Activated Protein Kinase Signaling and Inversely Correlates with ErbB2 in Human Breast Cancer. Molecular and Cellular Biology. 2010

 

STAT1: Research Trend, Expert Distribution, and Antibody Citation

STAT1: a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [1-5]

Fig 1. STAT1 Research Distribution. Institutions are ranked by number of related projects.

Fig 1. STAT1 Research Distribution. Institutions are ranked by number of related projects.

Research Overview

In the past 16 years, STAT1 research has been conducted in 407 research groups from 158 institutions in the United States. The accumulated number of projects: 1,556, and funding: $ 491 million.

 

Fig 2. Research Trend of STAT1 by annual NIH project number, funding, and NIH PI.

Fig 2. Research Trend of STAT1 by annual NIH project number, funding, and NIH PI.

Antibody Citation

STAT1 accounts for 0.4% of all publications in the past 15 years. 46 manufacturers have produced STAT1 antibody with citations appearing in peer review publications. The top suppliers are Cell Signaling Technology and Santa Cruz , accounting for around 75% of total citations. The annual citation trend are summarized below.

 

Fig 3. STAT1 Antibody Citation breakdown. Total citations from all providers from all years (2000-2014) are included.

Fig 3. STAT1 Antibody Citation breakdown. Total citations from all providers from all years (2000-2014) are included.

Fig 4

Fig 4. STAT1 Antibody Citation Trend: Annual product citation trend from each provider.

 

Closing Remarks:

This snapshot features a quantitative analysis for STAT1 research, and a cross-vendor comparison for STAT1 antibody manufacturers. It is aimed to provide a top-down perspective to deepen our understanding for STAT1; and an unbiased comparison for rational selection of STAT1 antibody. The complete list of publications found with STAT1 antibody citation from major open source publications can be viewed in STAT1 antibody comparison module.

 

Reference:

  1. STAT1 signal transducer and activator of transcription 1, Genbank
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  3. STAT1-dependent signal integration between IFNγ and TLR4 in vascular cells reflect pro-atherogenic responses in human atherosclerosis. Chmielewski S, et al. PLoS One, 2014
  4. Suppression of epithelial signal transducer and activator of transcription 1 activation by extracts of Aspergillus fumigatus. Bhushan B, et al. Am J Respir Cell Mol Biol, 2015
  5. Correlation of STAT1 with apoptosis and cell-cycle markers in esophageal squamous cell carcinoma. Zhang Y, et al. PLoS One, 2014.
  6. 15d-PGJ2 and Rosiglitazone Suppress Janus Kinase-STAT Inflammatory Signaling through Induction of Suppressor of Cytokine Signaling 1 (SOCS1) and SOCS3 in Glia. The Journal of Biological Chemistry. 2003
  7. 8p12 Stem Cell Myeloproliferative Disorder: the FOP-Fibroblast Growth Factor Receptor 1 Fusion Protein of the t(6;8) Translocation Induces Cell Survival Mediated by Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase/Akt/mTOR Pathways. Molecular and Cellular Biology. 2001
  8. A Co-Culture Model of the Developing Small Intestine Offers New Insight in the Early Immunomodulation of Enterocytes and Macrophages by Lactobacillus spp. through STAT1 and NF-kB p65 Translocation. PLoS ONE. 2014
  9. A Complex of Nuclear Factor I-X3 and STAT3 Regulates Astrocyte and Glioma Migration through the Secreted Glycoprotein YKL-40. The Journal of Biological Chemistry. 2011
  10. A Conserved Motif in the Linker Domain of STAT1 Transcription Factor Is Required for Both Recognition and Release from High-Affinity DNA-Binding Sites. PLoS ONE. 2014
  11. A Fusion Cytokine Coupling GMCSF to IL9 Induces Heterologous Receptor Clustering and STAT1 Hyperactivation through JAK2 Promiscuity. PLoS ONE. 2013
  12. A Molecular Model for the Differential Activation of STAT3 and STAT6 by the Herpesviral Oncoprotein Tip. PLoS ONE. 2012
  13. A Mutant Form of JAB/SOCS1 Augments the Cytokine-induced JAK/STAT Pathway by Accelerating Degradation of Wild-type JAB/CIS Family Proteins through the SOCS-box. The Journal of Biological Chemistry. 2001
  14. A Novel Disrupter of Telomere Silencing 1-like (DOT1L) Interaction Is Required for Signal Transducer and Activator of Transcription 1 (STAT1)-activated Gene Expression. The Journal of Biological Chemistry. 2011
  15. A Novel Requirement for Janus Kinases as Mediators of Drug Resistance Induced by Fibroblast Growth Factor-2 in Human Cancer Cells. PLoS ONE. 2011
  16. A Novel Viral SOCS from Infectious Spleen and Kidney Necrosis Virus: Interacts with Jak1 and Inhibits IFN-α Induced Stat1/3 Activation. PLoS ONE. 2012
  17. A Single Residue Modulates Tyrosine Dephosphorylation, Oligomerization, and Nuclear Accumulation of Stat Transcription Factors. The Journal of Biological Chemistry. 2004
  18. A STAT-responsive Element in the Promoter of the Episialin/MUC1 Gene Is Involved in Its Overexpression in Carcinoma Cells. The Journal of Biological Chemistry. 2001
  19. Aciculatin Inhibits Granulocyte Colony-Stimulating Factor Production by Human Interleukin 1β-Stimulated Fibroblast-Like Synoviocytes. PLoS ONE. 2012
  20. Activation and Inhibition of Anaplastic Lymphoma Kinase Receptor Tyrosine Kinase by Monoclonal Antibodies and Absence of Agonist Activity of Pleiotrophin. The Journal of Biological Chemistry. 2005
  21. Activation of ERα Signaling Differentially Modulates IFN-γ Induced HLA-Class II Expression in Breast Cancer Cells. PLoS ONE. 2014
  22. Activation of IFN-γ/STAT/IRF-1 in Hepatic Responses to Klebsiella pneumoniae Infection. PLoS ONE. 2013
  23. Activation of Protein Kinase C%CE%B4 by All-trans-retinoic Acid. The Journal of Biological Chemistry. 2003
  24. Activation of Protein Tyrosine Phosphatase Non-Receptor Type 2 by Spermidine Exerts Anti-Inflammatory Effects in Human THP-1 Monocytes and in a Mouse Model of Acute Colitis. PLoS ONE. 2013
  25. Activation of Rac1 and the p38 Mitogen-activated Protein Kinase Pathway in Response to All-trans-retinoic Acid. The Journal of Biological Chemistry. 2001
  26. Activation of Signal Transducer and Activator of Transcription 1 (STAT1) Is Not Sufficient for the Induction of STAT1-dependent Genes in Endothelial Cells:COMPARISON OF INTERFERON-%CE%B3 AND ONCOSTATIN M. The Journal of Biological Chemistry. 2002
  27. Activation of the Murine Interleukin-12 p40 Promoter by Functional Interactions between NFAT and ICSBP. The Journal of Biological Chemistry. 2003
  28. Activation of the Type I Interferon Pathway Is Enhanced in Response to Human Neuronal Differentiation. PLoS ONE. 2013
  29. Activation of Tyk2 and Stat3 Is Required for the Apoptotic Actions of Interferon-%CE%B2 in Primary Pro-B Cells. The Journal of Biological Chemistry. 2006
  30. Acute Control of Insulin-like Growth Factor-I Gene Transcription by Growth Hormone through Stat5b. The Journal of Biological Chemistry. 2003
  31. Acyl-CoA Synthetase 1 Is Induced by Gram-negative Bacteria and Lipopolysaccharide and Is Required for Phospholipid Turnover in Stimulated Macrophages. The Journal of Biological Chemistry. 2013
  32. Adenovirus E1A Down-regulates LMP2 Transcription by Interfering with the Binding of Stat1 to IRF1. The Journal of Biological Chemistry. 2000
  33. Adverse Effects of Simulated Hyper- and Hypo-Phosphatemia on Endothelial Cell Function and Viability. PLoS ONE. 2011
  34. Albumin Fusion of Interleukin-28B: Production and Characterization of Its Biological Activities and Protein Stability. PLoS ONE. 2013
  35. Altered Protein Networks and Cellular Pathways in Severe West Nile Disease in Mice. PLoS ONE. 2013
  36. Alternative Activation of STAT1 and STAT3 in Response to Interferon-%CE%B3. The Journal of Biological Chemistry. 2004
  37. An Interferon %CE%B12 Mutant Optimized by Phage Display for IFNAR1 Binding Confers Specifically Enhanced Antitumor Activities. The Journal of Biological Chemistry. 2007
  38. Analysis of SOCS-3 Promoter Responses to Interferon %CE%B3. The Journal of Biological Chemistry. 2004
  39. Antagonistic Regulation of Type I Collagen Gene Expression by Interferon-%CE%B3 and Transforming Growth Factor-%CE%B2:INTEGRATION AT THE LEVEL OF p300/CBP TRANSCRIPTIONAL COACTIVATORS. The Journal of Biological Chemistry. 2001
  40. Anti-CD70 Immunocytokines for Exploitation of Interferon-γ-Induced RIP1-Dependent Necrosis in Renal Cell Carcinoma. PLoS ONE. 2013
  41. AP-1 Transcription Factors, Mucin-Type Molecules and MMPs Regulate the IL-11 Mediated Invasiveness of JEG-3 and HTR-8/SVneo Trophoblastic Cells. PLoS ONE. 2011
  42. APE1/Ref-1 Regulates STAT3 Transcriptional Activity and APE1/Ref-1–STAT3 Dual-Targeting Effectively Inhibits Pancreatic Cancer Cell Survival. PLoS ONE. 2012
  43. Are STATS Arginine-methylated?. The Journal of Biological Chemistry. 2005
  44. Arginine/Lysine-rich Nuclear Localization Signals Mediate Interactions between Dimeric STATs and Importin %CE%B15. The Journal of Biological Chemistry. 2002
  45. Arginine/Lysine-rich Structural Element Is Involved in Interferon-induced Nuclear Import of STATs. The Journal of Biological Chemistry. 2001
  46. Autocrine-mediated Activation of STAT3 Correlates with Cell Proliferation in Breast Carcinoma Lines. The Journal of Biological Chemistry. 2002
  47. Beauvericin Ameliorates Experimental Colitis by Inhibiting Activated T Cells via Downregulation of the PI3K/Akt Signaling Pathway. PLoS ONE. 2013
  48. Berberine Differentially Modulates the Activities of ERK, p38 MAPK, and JNK to Suppress Th17 and Th1 T Cell Differentiation in Type 1 Diabetic Mice. The Journal of Biological Chemistry. 2009
  49. Biomarkers of Residual Disease, Disseminated Tumor Cells, and Metastases in the MMTV-PyMT Breast Cancer Model. PLoS ONE. 2013
  50. Bordetella pertussis Infection Exacerbates Influenza Virus Infection through Pertussis Toxin-Mediated Suppression of Innate Immunity. PLoS ONE. 2011
  51. Box 2 Region of the Oncostatin M Receptor Determines Specificity for Recruitment of Janus Kinases and STAT5 Activation. The Journal of Biological Chemistry. 2008
  52. Brevilin A, a Novel Natural Product, Inhibits Janus Kinase Activity and Blocks STAT3 Signaling in Cancer Cells. PLoS ONE. 2013
  53. C/EBP%CE%B4 and STAT-1 Are Required for TLR8 Transcriptional Activity. The Journal of Biological Chemistry. 2010
  54. C6 Glioma Cell Insoluble Matrix Components Enhance Interferon-%CE%B3-stimulated Inducible Nitric-oxide Synthase/Nitric Oxide Production in BV2 Microglial Cells. The Journal of Biological Chemistry. 2008
  55. Cannabinoids %CE%949-Tetrahydrocannabinol and Cannabidiol Differentially Inhibit the Lipopolysaccharide-activated NF-%CE%BAB and Interferon-%CE%B2/STAT Proinflammatory Pathways in BV-2 Microglial Cells. The Journal of Biological Chemistry. 2010
  56. Carbon Monoxide Differentially Modulates STAT1 and STAT3 and Inhibits Apoptosis via a Phosphatidylinositol 3-Kinase/Akt and p38 Kinase-dependent STAT3 Pathway during Anoxia-Reoxygenation Injury. The Journal of Biological Chemistry. 2005
  57. Cardiotrophin-1 Induces Matrix Metalloproteinase-1 in Human Aortic Endothelial Cells. PLoS ONE. 2013
  58. Caspase-11 Gene Expression in Response to Lipopolysaccharide and Interferon-%CE%B3 Requires Nuclear Factor-%CE%BAB and Signal Transducer and Activator of Transcription (STAT) 1. The Journal of Biological Chemistry. 2002
  59. CCAAT Enhancer-binding Protein %CE%B1 Is Required for Interleukin-6 Receptor %CE%B1 Signaling in Newborn Hepatocytes. The Journal of Biological Chemistry. 2004
  60. CCAAT/Enhancer-binding Protein %CE%B2 Mediates Interferon-%CE%B3-induced p48 (ISGF3-%CE%B3) Gene Transcription in Human Monocytic Cells. The Journal of Biological Chemistry. 2001
  61. CD69 Association with Jak3/Stat5 Proteins Regulates Th17 Cell Differentiation. Molecular and Cellular Biology. 2010
  62. Celastrol Inhibits Lung Infiltration in Differential Syndrome Animal Models by Reducing TNF-α and ICAM-1 Levels while Preserving Differentiation in ATRA-Induced Acute Promyelocytic Leukemia Cells. PLoS ONE. 2014
  63. Cell Confluence-induced Activation of Signal Transducer and Activator of Transcription-3 (Stat3) Triggers Epithelial Dome Formation via Augmentation of Sodium Hydrogen Exchanger-3 (NHE3) Expression. The Journal of Biological Chemistry. 2007
  64. Cells Previously Desensitized to Type 1 Interferons Display Different Mechanisms of Activation of Stat-dependent Gene Expression from Na%C3%AFve Cells. The Journal of Biological Chemistry. 2004
  65. Characterization of Phosphopeptide Motifs Specific for the Src Homology 2 Domains of Signal Transducer and Activator of Transcription 1 (STAT1) and STAT3. The Journal of Biological Chemistry. 2003
  66. Characterization of the Signaling Capacities of the Novel gp130-like Cytokine Receptor. The Journal of Biological Chemistry. 2004
  67. Cigarette Smoke Modulates Expression of Human Rhinovirus-Induced Airway Epithelial Host Defense Genes. PLoS ONE. 2012
  68. Clinically Relevant Dimer Interface Mutants of STAT1 Transcription Factor Exhibit Differential Gene Expression. PLoS ONE. 2013
  69. cmvIL-10 Stimulates the Invasive Potential of MDA-MB-231 Breast Cancer Cells. PLoS ONE. 2014
  70. Comparison of Macrophage Antimicrobial Responses Induced by Type II Interferons of the Goldfish (Carassius auratus L.). The Journal of Biological Chemistry. 2010
  71. Concanavalin A/IFN-Gamma Triggers Autophagy-Related Necrotic Hepatocyte Death through IRGM1-Mediated Lysosomal Membrane Disruption. PLoS ONE. 2011
  72. Constitutive and IFN-[gamma]-induced nuclear import of STAT1 proceed through independent pathways. The EMBO Journal. 2002
  73. Constitutive nuclear import of latent and activated STAT5a by its coiled coil domain. The FASEB Journal. 2008
  74. Constitutively Activated Stat3 Induces Tumorigenesis and Enhances Cell Motility of Prostate Epithelial Cells through Integrin %CE%B26. Molecular and Cellular Biology. 2007
  75. Constitutively Active Mutant gp130 Receptor Protein from Inflammatory Hepatocellular Adenoma Is Inhibited by an Anti-gp130 Antibody That Specifically Neutralizes Interleukin 11 Signaling. The Journal of Biological Chemistry. 2012
  76. Contribution of Interferon-%CE%B2 to the Murine Macrophage Response to the Toll-like Receptor 4 Agonist, Lipopolysaccharide. The Journal of Biological Chemistry. 2006
  77. Co-operative Effect of c-Src Tyrosine Kinase and Stat3 in Activation of Hepatocyte Growth Factor Expression in Mammary Carcinoma Cells. The Journal of Biological Chemistry. 2001
  78. Correlation of STAT1 with Apoptosis and Cell-Cycle Markers in Esophageal Squamous Cell Carcinoma. PLoS ONE. 2014
  79. Coxsackievirus Cloverleaf RNA Containing a 5′ Triphosphate Triggers an Antiviral Response via RIG-I Activation. PLoS ONE. 2014
  80. Curcumin Inhibits Neuronal and Vascular Degeneration in Retina after Ischemia and Reperfusion Injury. PLoS ONE. 2011
  81. Curcumin Suppresses the Induction of Indoleamine 2,3-Dioxygenase by Blocking the Janus-activated Kinase-Protein Kinase C%CE%B4-STAT1 Signaling Pathway in Interferon-%CE%B3-stimulated Murine Dendritic Cells. The Journal of Biological Chemistry. 2009
  82. CXCL12 Signaling Is Independent of Jak2 and Jak3. The Journal of Biological Chemistry. 2005
  83. Cyanidin-3-Glucoside Suppresses Cytokine-Induced Inflammatory Response in Human Intestinal Cells: Comparison with 5-Aminosalicylic Acid. PLoS ONE. 2013
  84. Cytokine Receptor-Like Factor 1 (CRLF1) Protects against 6-Hydroxydopamine Toxicity Independent of the gp130/JAK Signaling Pathway. PLoS ONE. 2013
  85. Cytokine Signaling through Stat3 Activates Integrins, Promotes Adhesion, and Induces Growth Arrest in the Myeloid Cell Line 32D. The Journal of Biological Chemistry. 2000
  86. Cytokine Signaling:STATS IN PLASMA MEMBRANE RAFTS. The Journal of Biological Chemistry. 2002
  87. Cytokines Tumor Necrosis Factor-%CE%B1 and Interferon-%CE%B3 Induce Pancreatic %CE%B2-Cell Apoptosis through STAT1-mediated Bim Protein Activation. The Journal of Biological Chemistry. 2011
  88. Defects in Innate Immunity Render Breast Cancer Initiating Cells Permissive to Oncolytic Adenovirus. PLoS ONE. 2010
  89. Definition and Characterization of an Inhibitor for Interleukin-31. The Journal of Biological Chemistry. 2010
  90. Differential Effects of Lipoprotein Lipase on Tumor Necrosis Factor-%CE%B1 and Interferon-%CE%B3-mediated Gene Expression in Human Endothelial Cells. The Journal of Biological Chemistry. 2005
  91. Differential Regulation of STAT Family Members by Glycogen Synthase Kinase-3. The Journal of Biological Chemistry. 2008
  92. Dimerization of Vaccinia Virus VH1 Is Essential for Dephosphorylation of STAT1 at Tyrosine 701. The Journal of Biological Chemistry. 2011
  93. Dissecting the Molecular Mechanism of Ionizing Radiation-Induced Tissue Damage in the Feather Follicle. PLoS ONE. 2014
  94. Dissociation Time from DNA Determines Transcriptional Function in a STAT1 Linker Mutant. The Journal of Biological Chemistry. 2002
  95. Distinct Mechanisms of STAT Phosphorylation via the Interferon-%CE%B1/%CE%B2 Receptor:SELECTIVE INHIBITION OF STAT3 AND STAT5 BY PICEATANNOL. The Journal of Biological Chemistry. 2000
  96. Distinct Regions of the Interleukin-7 Receptor Regulate Different Bcl2 Family Members. Molecular and Cellular Biology. 2004
  97. Distinct Roles of Transforming Growth Factor-%CE%B2-activated Kinase 1 (TAK1)-c-Rel and Interferon Regulatory Factor 4 (IRF4) Pathways in Human T Cell Lymphotropic Virus 1-transformed T helper 17 Cells Producing Interleukin-9. The Journal of Biological Chemistry. 2011
  98. Domain 2 of the Urokinase Receptor Contains an Integrin-interacting Epitope with Intrinsic Signaling Activity:GENERATION OF A NEW INTEGRIN INHIBITOR. The Journal of Biological Chemistry. 2005
  99. Double-stranded RNAs from the Helminth Parasite Schistosoma Activate TLR3 in Dendritic Cells. The Journal of Biological Chemistry. 2005
  100. Dual Function of Interleukin-1%CE%B2 for the Regulation of Interleukin-6-induced Suppressor of Cytokine Signaling 3 Expression. The Journal of Biological Chemistry. 2004
  101. Early Activation of Rat Skeletal Muscle IL-6/STAT1/STAT3 Dependent Gene Expression in Resistance Exercise Linked to Hypertrophy. PLoS ONE. 2013
  102. Effects of Cardiotrophin on Adipocytes. The Journal of Biological Chemistry. 2004
  103. Effects of Imatinib Mesylate (Gleevec) on Human Islet NF-kappaB Activation and Chemokine Production In Vitro. PLoS ONE. 2011
  104. Elevated Activity of STAT3C due to Higher DNA Binding Affinity of Phosphotyrosine Dimer Rather than Covalent Dimer Formation. The Journal of Biological Chemistry. 2006
  105. Engagement of Protein Kinase C-%CE%B8 in Interferon Signaling in T-cells. The Journal of Biological Chemistry. 2004
  106. Enhanced Antiviral and Antiproliferative Properties of a STAT1 Mutant Unable to Interact with the Protein Kinase PKR. The Journal of Biological Chemistry. 2001
  107. Enhancement of Cell Type Specificity by Quantitative Modulation of a Chimeric Ligand. The Journal of Biological Chemistry. 2008
  108. Epigenetic Silencing of IRF7 and/or IRF5 in Lung Cancer Cells Leads to Increased Sensitivity to Oncolytic Viruses. PLoS ONE. 2011
  109. Epstein-Barr Virus Independent Dysregulation of UBP43 Expression Alters Interferon-Stimulated Gene Expression in Burkitt Lymphoma. PLoS ONE. 2009
  110. Epstein-Barr Virus Interferes with the Amplification of IFNα Secretion by Activating Suppressor of Cytokine Signaling 3 in Primary Human Monocytes. PLoS ONE. 2010
  111. Essential Role for IKK%CE%B2 in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells. The Journal of Biological Chemistry. 2012
  112. Essential Role for Mnk Kinases in Type II Interferon (IFN%CE%B3) Signaling and Its Suppressive Effects on Normal Hematopoiesis. The Journal of Biological Chemistry. 2011
  113. Essential Role for the Mnk Pathway in the Inhibitory Effects of Type I Interferons on Myeloproliferative Neoplasm (MPN) Precursors. The Journal of Biological Chemistry. 2013
  114. Essential Role of STAT1 in Caspase-Independent Cell Death of Activated Macrophages through the p38 Mitogen-Activated Protein Kinase/STAT1/Reactive Oxygen Species Pathway. Molecular and Cellular Biology. 2005
  115. Essential Role of the JAK/STAT1 Signaling Pathway in the Expression of Inducible Nitric-oxide Synthase in Intestinal Epithelial Cells and Its Regulation by Butyrate. The Journal of Biological Chemistry. 2007
  116. Essential Role of Ubiquitin-Specific Protease 8 for Receptor Tyrosine Kinase Stability and Endocytic Trafficking In Vivo. Molecular and Cellular Biology. 2007
  117. Etk, a Btk Family Tyrosine Kinase, Mediates Cellular Transformation by Linking Src to STAT3 Activation. Molecular and Cellular Biology. 2000
  118. Evasion of IFN-γ Signaling by Francisella novicida Is Dependent upon Francisella Outer Membrane Protein C. PLoS ONE. 2011
  119. Excess Type I Interferon Signaling in the Mouse Seminiferous Tubules Leads to Germ Cell Loss and Sterility. The Journal of Biological Chemistry. 2011
  120. Expression of an IKKγ Splice Variant Determines IRF3 and Canonical NF-κB Pathway Utilization in ssRNA Virus Infection. PLoS ONE. 2009
  121. Fibronectin and %CE%B2-Catenin Act in a Regulatory Loop in Dermal Fibroblasts to Modulate Cutaneous Healing. The Journal of Biological Chemistry. 2011
  122. Fludarabine Downregulates Indoleamine 2,3-Dioxygenase in Tumors via a Proteasome-Mediated Degradation Mechanism. PLoS ONE. 2014
  123. Focal Adhesion Kinase Activates Stat1 in Integrin-mediated Cell Migration and Adhesion. The Journal of Biological Chemistry. 2001
  124. Fragile X-related Protein FXR1P Regulates Proinflammatory Cytokine Tumor Necrosis Factor Expression at the Post-transcriptional Level. The Journal of Biological Chemistry. 2005
  125. Free radical scavenging inhibits STAT phosphorylation following in vivo ischemia/reperfusion injury. The FASEB Journal. 2006
  126. From Macrophage Interleukin-13 Receptor to Foam Cell Formation:MECHANISMS FOR %CE%B1M%CE%B22 INTEGRIN INTERFERENCE. The Journal of Biological Chemistry. 2013
  127. Full Oncogenic Activities of v-Src Are Mediated by Multiple Signaling Pathways:Ras AS AN ESSENTIAL MEDIATOR FOR CELL SURVIVAL. The Journal of Biological Chemistry. 2000
  128. Functional Dissection Identifies a Conserved Noncoding Sequence-1 Core That Mediates IL13 and IL4 Transcriptional Enhancement. The Journal of Biological Chemistry. 2007
  129. Functional Relevance of the Conserved DNA-binding Domain of STAT2. The Journal of Biological Chemistry. 2005
  130. Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells. The FASEB Journal. 2002
  131. Generation of Replication-Proficient Influenza Virus NS1 Point Mutants with Interferon-Hyperinducer Phenotype. PLoS ONE. 2014
  132. GLI2 Transcription Factor Mediates Cytokine Cross-talk in the Tumor Microenvironment. The Journal of Biological Chemistry. 2011
  133. Harnessing High Density Lipoproteins to Block Transforming Growth Factor Beta and to Inhibit the Growth of Liver Tumor Metastases. PLoS ONE. 2014
  134. Hck Is a Key Regulator of Gene Expression in Alternatively Activated Human Monocytes. The Journal of Biological Chemistry. 2011
  135. Heparanase Induces Signal Transducer and Activator of Transcription (STAT) Protein Phosphorylation:PRECLINICAL AND CLINICAL SIGNIFICANCE IN HEAD AND NECK CANCER. The Journal of Biological Chemistry. 2012
  136. Hepatitis C Virus Core Protein Differently Regulates the JAK-STAT Signaling Pathway under Interleukin-6 and Interferon-%CE%B3 Stimuli. The Journal of Biological Chemistry. 2003
  137. Hepatitis C Virus Core Protein Inhibits Interferon Production by a Human Plasmacytoid Dendritic Cell Line and Dysregulates Interferon Regulatory Factor-7 and Signal Transducer and Activator of Transcription (STAT) 1 Protein Expression. PLoS ONE. 2014
  138. High-throughput Immunoblotting:UBIQUITIN-LIKE PROTEIN ISG15 MODIFIES KEY REGULATORS OF SIGNAL TRANSDUCTION. The Journal of Biological Chemistry. 2003
  139. Histone Deacetylase Activity Is Required to Recruit RNA Polymerase II to the Promoters of Selected Interferon-stimulated Early Response Genes. The Journal of Biological Chemistry. 2004
  140. HIV Nef Inhibits T Cell Migration. The Journal of Biological Chemistry. 2002
  141. HIV-1 Nef Induces Proinflammatory State in Macrophages through Its Acidic Cluster Domain: Involvement of TNF Alpha Receptor Associated Factor 2. PLoS ONE. 2011
  142. HIV-1 Tat Co-Operates with IFN-γ and TNF-α to Increase CXCL10 in Human Astrocytes. PLoS ONE. 2009
  143. HIV-1 Vpr Induces Interferon-Stimulated Genes in Human Monocyte-Derived Macrophages. PLoS ONE. 2014
  144. Human Cell Chips: Adapting DNA Microarray Spotting Technology to Cell-Based Imaging Assays. PLoS ONE. 2009
  145. Human Metapneumovirus Inhibits IFN-β Signaling by Downregulating Jak1 and Tyk2 Cellular Levels. PLoS ONE. 2011
  146. Human Papillomavirus 16 E5 Modulates the Expression of Host MicroRNAs. PLoS ONE. 2011
  147. Human Serum from Patients with Septic Shock Activates Transcription Factors STAT1, IRF1, and NF-%CE%BAB and Induces Apoptosis in Human Cardiac Myocytes. The Journal of Biological Chemistry. 2005
  148. Identification of a Novel Conserved Motif in the STAT Family That Is Required for Tyrosine Phosphorylation. The Journal of Biological Chemistry. 2004
  149. Identification of a nuclear localization signal in suppressor of cytokine signaling 1. The FASEB Journal. 2008
  150. Identification of a Nuclear Stat1 Protein Tyrosine Phosphatase. Molecular and Cellular Biology. 2002
  151. Identification of Both Positive and Negative Domains within the Epidermal Growth Factor Receptor COOH-terminal Region for Signal Transducer and Activator of Transcription (STAT) Activation. The Journal of Biological Chemistry. 2002
  152. Identification of Canonical Tyrosine-dependent and Non-canonical Tyrosine-independent STAT3 Activation Sites in the Intracellular Domain of the Interleukin 23 Receptor. The Journal of Biological Chemistry. 2013
  153. Identification of Human STAT5-dependent Gene Regulatory Elements Based on Interspecies Homology. The Journal of Biological Chemistry. 2006
  154. Identification of Pro-Inflammatory Cytokines Associated with Muscle Invasive Bladder Cancer; The Roles of IL-5, IL-20, and IL-28A. PLoS ONE. 2012
  155. Identification of Residues of SARS-CoV nsp1 That Differentially Affect Inhibition of Gene Expression and Antiviral Signaling. PLoS ONE. 2013
  156. Identification of STAT2 Serine 287 as a Novel Regulatory Phosphorylation Site in Type I Interferon-induced Cellular Responses. The Journal of Biological Chemistry. 2013
  157. Identification of the Jak/Stat Proteins as Novel Downstream Targets of EphA4 Signaling in Muscle:IMPLICATIONS IN THE REGULATION OF ACETYLCHOLINESTERASE EXPRESSION. The Journal of Biological Chemistry. 2004
  158. Identification of Transforming Hepatitis B Virus S Gene Nonsense Mutations Derived from Freely Replicative Viruses in Hepatocellular Carcinoma. PLoS ONE. 2014
  159. IFN-α Is Constitutively Expressed in the Human Thymus, but Not in Peripheral Lymphoid Organs. PLoS ONE. 2011
  160. IFN-γ and TNF-α Synergize to Inhibit CTGF Expression in Human Lung Endothelial Cells. PLoS ONE. 2012
  161. IL-27 Enhances the Expression of TRAIL and TLR3 in Human Melanomas and Inhibits Their Tumor Growth in Cooperation with a TLR3 Agonist Poly(I:C) Partly in a TRAIL-Dependent Manner. PLoS ONE. 2013
  162. IL-4 Suppresses the Responses to TLR7 and TLR9 Stimulation and Increases the Permissiveness to Retroviral Infection of Murine Conventional Dendritic Cells. PLoS ONE. 2014
  163. IL-7 Promotes CD95-Induced Apoptosis in B Cells via the IFN-γ/STAT1 Pathway. PLoS ONE. 2011
  164. Impaired Cellular Responses to Cytosolic DNA or Infection with Listeria monocytogenes and Vaccinia Virus in the Absence of the Murine LGP2 Protein. PLoS ONE. 2011
  165. Impaired IgG Production in Mice Deficient for Heat Shock Transcription Factor 1. The Journal of Biological Chemistry. 2004
  166. Importin %CE%B1 Nuclear Localization Signal Binding Sites for STAT1, STAT2, and Influenza A Virus Nucleoprotein. The Journal of Biological Chemistry. 2003
  167. Inactivation of Mammalian Target of Rapamycin Increases STAT1 Nuclear Content and Transcriptional Activity in %CE%B14- and Protein Phosphatase 2A-dependent Fashion. The Journal of Biological Chemistry. 2009
  168. Incorporation of a Dietary Omega 3 Fatty Acid Impairs Murine Macrophage Responses to Mycobacterium tuberculosis. PLoS ONE. 2010
  169. Increased K+ Efflux and Apoptosis Induced by the Potassium Channel Modulatory Protein KChAP/PIAS3%CE%B2 in Prostate Cancer Cells. The Journal of Biological Chemistry. 2002
  170. Increased Myeloproliferation in Glutathione S-Transferase %CF%80-deficient Mice Is Associated with a Deregulation of JNK and Janus Kinase/STAT Pathways. The Journal of Biological Chemistry. 2004
  171. Increased STAT1 Signaling in Endocrine-Resistant Breast Cancer. PLoS ONE. 2014
  172. Increased Susceptibility to Dextran Sulfate Sodium Induced Colitis in the T Cell Protein Tyrosine Phosphatase Heterozygous Mouse. PLoS ONE. 2010
  173. Independent and Cooperative Activation of Chromosomal c-fos Promoter by STAT3. The Journal of Biological Chemistry. 2003
  174. Inducible Priming Phosphorylation Promotes Ligand-independent Degradation of the IFNAR1 Chain of Type I Interferon Receptor. The Journal of Biological Chemistry. 2010
  175. Inducible, Dose-Adjustable and Time-Restricted Reconstitution of Stat1 Deficiency In Vivo. PLoS ONE. 2014
  176. Induction of Bv8 Expression by Granulocyte Colony-stimulating Factor in CD11b+Gr1+ Cells:KEY ROLE OF Stat3 SIGNALING. The Journal of Biological Chemistry. 2012
  177. Induction of Genes Mediating Interferon-dependent Extracellular Trap Formation during Neutrophil Differentiation. The Journal of Biological Chemistry. 2004
  178. Influenza A Virus Induces Interleukin-27 through Cyclooxygenase-2 and Protein Kinase A Signaling. The Journal of Biological Chemistry. 2012
  179. Influenza Virus Non-Structural Protein 1 (NS1) Disrupts Interferon Signaling. PLoS ONE. 2010
  180. Inhibition of Inflammatory and Proliferative Responses of Human Keratinocytes Exposed to the Sesquiterpene Lactones Dehydrocostuslactone and Costunolide. PLoS ONE. 2014
  181. Inhibition of Interferon (IFN) %CE%B3-induced Jak-STAT1 Activation in Microglia by Vasoactive Intestinal Peptide:INHIBITORY EFFECT ON CD40, IFN-INDUCED PROTEIN-10, AND INDUCIBLE NITRIC-OXIDE SYNTHASE EXPRESSION. The Journal of Biological Chemistry. 2003
  182. Inhibition of Interferon Induction and Action by the Nairovirus Nairobi Sheep Disease Virus/Ganjam Virus. PLoS ONE. 2011
  183. Inhibition of Signal Transducer and Activator of Transcription 3 (STAT3) Attenuates Interleukin-6 (IL-6)-induced Collagen Synthesis and Resultant Hypertrophy in Rat Heart. The Journal of Biological Chemistry. 2012
  184. Inhibition of STAT3 Signaling Blocks the Anti-apoptotic Activity of IL-6 in Human Liver Cancer Cells. The Journal of Biological Chemistry. 2010
  185. Inhibition of Tumor Necrosis Factor %CE%B1-mediated NF%CE%BAB Activation and Leukocyte Adhesion, with Enhanced Endothelial Apoptosis, by G Protein-linked Receptor (TP) Ligands. The Journal of Biological Chemistry. 2003
  186. Inhibitor of %CE%BAB Kinase %CF%B5 (IKK%CF%B5), STAT1, and IFIT2 Proteins Define Novel Innate Immune Effector Pathway against West Nile Virus Infection. The Journal of Biological Chemistry. 2011
  187. Innate Immunity in Pluripotent Human Cells:ATTENUATED RESPONSE TO INTERFERON-%CE%B2. The Journal of Biological Chemistry. 2013
  188. Interaction of G-Protein βγ Complex with Chromatin Modulates GPCR-Dependent Gene Regulation. PLoS ONE. 2013
  189. Interaction of G-Protein βγ Complex with Chromatin Modulates GPCR-Dependent Gene Regulation. PLoS ONE. 2012
  190. Interactions of STAT3 with Caveolin-1 and Heat Shock Protein 90 in Plasma Membrane Raft and Cytosolic Complexes:PRESERVATION OF CYTOKINE SIGNALING DURING FEVER. The Journal of Biological Chemistry. 2002
  191. Interferon %CE%B1 but Not Interleukin 12 Activates STAT4 Signaling in Human Vascular Endothelial Cells. The Journal of Biological Chemistry. 2004
  192. Interferon %CE%B1-induced Apoptosis in Tumor Cells Is Mediated through the Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Signaling Pathway. The Journal of Biological Chemistry. 2004
  193. Interferon %CE%B3 Attenuates Insulin Signaling, Lipid Storage, and Differentiation in Human Adipocytes via Activation of the JAK/STAT Pathway. The Journal of Biological Chemistry. 2009
  194. Interferon Regulatory Factor-8 Is Important for Histone Deacetylase Inhibitor-Mediated Antitumor Activity. PLoS ONE. 2012
  195. Interferon Signaling Is Dependent on Specific Tyrosines Located within the Intracellular Domain of IFNAR2c:EXPRESSION OF IFNAR2c TYROSINE MUTANTS IN U5A CELLS. The Journal of Biological Chemistry. 2002
  196. Interferon%CE%B1 Activates NF-%CE%BAB in JAK1-deficient Cells through a TYK2-dependent Pathway. The Journal of Biological Chemistry. 2005
  197. Interferon-%CE%B1 Induces Nmi-IFP35 Heterodimeric Complex Formation That Is Affected by the Phosphorylation of IFP35. The Journal of Biological Chemistry. 2000
  198. Interferon-%CE%B1-induced Expression of Phospholipid Scramblase 1 through STAT1 Requires the Sequential Activation of Protein Kinase C%CE%B4 and JNK. The Journal of Biological Chemistry. 2005
  199. Interferon-%CE%B3 Differentially Regulates Monocyte Matrix Metalloproteinase-1 and -9 through Tumor Necrosis Factor-%CE%B1 and Caspase 8. The Journal of Biological Chemistry. 2003
  200. Interferon-%CE%B3 Has Dual Potentials in Inhibiting or Promoting Cell Proliferation. The Journal of Biological Chemistry. 2000
  201. Interferon-%CE%B3 Induces p11 Gene and Protein Expression in Human Epithelial Cells through Interferon-%CE%B3-activated Sequences in the p11Promoter. The Journal of Biological Chemistry. 2003
  202. Interferon-%CE%B3 Induces X-linked Inhibitor of Apoptosis-associated Factor-1 and Noxa Expression and Potentiates Human Vascular Smooth Muscle Cell Apoptosis by STAT3 Activation. The Journal of Biological Chemistry. 2008
  203. Interferon-%CE%B3 Interferes with Transforming Growth Factor-%CE%B2 Signaling through Direct Interaction of YB-1 with Smad3. The Journal of Biological Chemistry. 2003
  204. Interferon-%CE%B3-induced MD-2 Protein Expression and Lipopolysaccharide (LPS) Responsiveness in Corneal Epithelial Cells Is Mediated by Janus Tyrosine Kinase-2 Activation and Direct Binding of STAT1 Protein to the MD-2 Promoter. The Journal of Biological Chemistry. 2011
  205. Interferon-%CE%B3-mediated Inhibition of Serum Response Factor-dependent Smooth Muscle-specific Gene Expression. The Journal of Biological Chemistry. 2010
  206. Interferon-[gamma]-induced chromatin remodeling at the CIITA locus is BRG1 dependent. The EMBO Journal. 2002
  207. Interferon-Alpha Triggers B Cell Effector 1 (Be1) Commitment. PLoS ONE. 2011
  208. Interferon-resistant Daudi Cell Line with a Stat2 Defect Is Resistant to Apoptosis Induced by Chemotherapeutic Agents. The Journal of Biological Chemistry. 2009
  209. Interferons Inhibit Tumor Necrosis Factor-%CE%B1-mediated Matrix Metalloproteinase-9 Activation via Interferon Regulatory Factor-1 Binding Competition with NF-%CE%BAB. The Journal of Biological Chemistry. 2002
  210. Interferon-α Regulates Glutaminase 1 Promoter through STAT1 Phosphorylation: Relevance to HIV-1 Associated Neurocognitive Disorders. PLoS ONE. 2012
  211. Interferon-γ Induces Senescence in Normal Human Melanocytes. PLoS ONE. 2014
  212. Interferon-γ Produced by Microglia and the Neuropeptide PACAP Have Opposite Effects on the Viability of Neural Progenitor Cells. PLoS ONE. 2010
  213. Interferon-γ Upregulates Expression of IFP35 Gene in HeLa Cells via Interferon Regulatory Factor-1. PLoS ONE. 2012
  214. Interferon-λ1 Linked to a Stabilized Dimer of Fab Potently Enhances both Antitumor and Antiviral Activities in Targeted Cells. PLoS ONE. 2013
  215. Interleukin 27 Induces the Expression of Complement Factor H (CFH) in the Retina. PLoS ONE. 2012
  216. Interleukin-13 Induction of 15-Lipoxygenase Gene Expression Requires p38 Mitogen-Activated Protein Kinase-Mediated Serine 727 Phosphorylation of Stat1 and Stat3. Molecular and Cellular Biology. 2003
  217. Interleukin-15 regulates proliferation and self-renewal of adult neural stem cells. Molecular Biology of the Cell. 2011
  218. Interleukin-20 Promotes Migration of Bladder Cancer Cells through Extracellular Signal-regulated Kinase (ERK)-mediated MMP-9 Protein Expression Leading to Nuclear Factor (NF-%CE%BAB) Activation by Inducing the Up-regulation of p21WAF1 Protein Expression. The Journal of Biological Chemistry. 2013
  219. Interleukin-22 (IL-22) Activates the JAK/STAT, ERK, JNK, and p38 MAP Kinase Pathways in a Rat Hepatoma Cell Line:PATHWAYS THAT ARE SHARED WITH AND DISTINCT FROM IL-10. The Journal of Biological Chemistry. 2002
  220. Interleukin-22 Suppresses the Growth of A498 Renal Cell Carcinoma Cells via Regulation of STAT1 Pathway. PLoS ONE. 2011
  221. Interleukin-27 Induces a STAT1/3- and NF-%CE%BAB-dependent Proinflammatory Cytokine Profile in Human Monocytes. The Journal of Biological Chemistry. 2010
  222. Interleukin-31 and Oncostatin-M Mediate Distinct Signaling Reactions and Response Patterns in Lung Epithelial Cells. The Journal of Biological Chemistry. 2007
  223. Interleukin-4 Induces Senescence in Human Renal Carcinoma Cell Lines through STAT6 and p38 MAPK. The Journal of Biological Chemistry. 2013
  224. Interleukin-4/STAT6 Represses STAT1 and NF-%CE%BAB-dependent Transcription through Distinct Mechanisms. The Journal of Biological Chemistry. 2000
  225. Interleukin-6 Regulation of Transforming Growth Factor (TGF)-%CE%B2 Receptor Compartmentalization and Turnover Enhances TGF-%CE%B21 Signaling. The Journal of Biological Chemistry. 2005
  226. Interleukin-6/Glycoprotein 130-dependent Pathways Are Protective during Liver Regeneration. The Journal of Biological Chemistry. 2003
  227. Interleukin-7 Compartmentalizes Its Receptor Signaling Complex to Initiate CD4 T Lymphocyte Response. The Journal of Biological Chemistry. 2010
  228. Intertissue Flow of Glutathione (GSH) as a Tumor Growth-promoting Mechanism:INTERLEUKIN 6 INDUCES GSH RELEASE FROM HEPATOCYTES IN METASTATIC B16 MELANOMA-BEARING MICE. The Journal of Biological Chemistry. 2011
  229. IRF3-dependent Type I Interferon Response in B Cells Regulates CpG-mediated Antibody Production. The Journal of Biological Chemistry. 2008
  230. ISG15 Modulates Development of the Erythroid Lineage. PLoS ONE. 2011
  231. JAK/STAT but Not ERK1/ERK2 Pathway Mediates Interleukin (IL)-6/Soluble IL-6R Down-regulation of Type II Collagen, Aggrecan Core, and Link Protein Transcription in Articular Chondrocytes:ASSOCIATION WITH A DOWN-REGULATION OF SOX9 EXPRESSION. The Journal of Biological Chemistry. 2003
  232. Jak2 Acts as Both a STAT1 Kinase and as a Molecular Bridge Linking STAT1 to the Angiotensin II AT1 Receptor. The Journal of Biological Chemistry. 2000
  233. JAK2 and SHP2 Reciprocally Regulate Tyrosine Phosphorylation and Stability of Proapoptotic Protein ASK1. The Journal of Biological Chemistry. 2009
  234. Jak2 Tyrosine Kinase Mediates Angiotensin II-dependent Inactivation of ERK2 via Induction of Mitogen-activated Protein Kinase Phosphatase 1. The Journal of Biological Chemistry. 2004
  235. Jak2 Tyrosine Kinase Mediates Oxidative Stress-induced Apoptosis in Vascular Smooth Muscle Cells. The Journal of Biological Chemistry. 2004
  236. JAK2/STAT2/STAT3 Are Required for Myogenic Differentiation. The Journal of Biological Chemistry. 2008
  237. JAK-STAT Signaling Mediates Gangliosides-induced Inflammatory Responses in Brain Microglial Cells. The Journal of Biological Chemistry. 2002
  238. Janus Kinase (Jak) Subcellular Localization Revisited:THE EXCLUSIVE MEMBRANE LOCALIZATION OF ENDOGENOUS JANUS KINASE 1 BY CYTOKINE RECEPTOR INTERACTION UNCOVERS THE Jak%C2%B7RECEPTOR COMPLEX TO BE EQUIVALENT TO A RECEPTOR TYROSINE KINASE. The Journal of Biological Chemistry. 2004
  239. Janus Kinases Affect Thrombopoietin Receptor Cell Surface Localization and Stability. The Journal of Biological Chemistry. 2005
  240. Jun Activation Domain-binding Protein 1 (JAB1) Is Required for the Optimal Response to Interferons. The Journal of Biological Chemistry. 2013
  241. Kinetics of a Gamma Interferon Response: Expression and Assembly of CIITA Promoter IV and Inhibition by Methylation. Molecular and Cellular Biology. 2002
  242. Kinome-wide Selectivity Profiling of ATP-competitive Mammalian Target of Rapamycin (mTOR) Inhibitors and Characterization of Their Binding Kinetics. The Journal of Biological Chemistry. 2012
  243. Laquinimod, a Quinoline-3-Carboxamide, Induces Type II Myeloid Cells That Modulate Central Nervous System Autoimmunity. PLoS ONE. 2012
  244. LC/MS-Based Quantitative Proteomic Analysis of Paraffin-Embedded Archival Melanomas Reveals Potential Proteomic Biomarkers Associated with Metastasis. PLoS ONE. 2009
  245. Leptin Activates the Anandamide Hydrolase Promoter in Human T Lymphocytes through STAT3. The Journal of Biological Chemistry. 2003
  246. Leptin Increases Axonal Growth Cone Size in Developing Mouse Cortical Neurons by Convergent Signals Inactivating Glycogen Synthase Kinase-3%CE%B2. The Journal of Biological Chemistry. 2006
  247. Leptin Induces Apoptosis via ERK/cPLA2/Cytochrome c Pathway in Human Bone Marrow Stromal Cells. The Journal of Biological Chemistry. 2003
  248. Leukemia Inhibitory Factor Induces DNA Synthesis in Swiss Mouse 3T3 Cells Independently of Cyclin D1 Expression through a Mechanism Involving MEK/ERK1/2 Activation. The Journal of Biological Chemistry. 2006
  249. Leukotriene B4 Receptor-2 Promotes Invasiveness and Metastasis of Ovarian Cancer Cells through Signal Transducer and Activator of Transcription 3 (STAT3)-dependent Up-regulation of Matrix Metalloproteinase 2. The Journal of Biological Chemistry. 2012
  250. Ligand-regulated Chimeric Receptor Approach Reveals Distinctive Subcellular Localization and Signaling Properties of the Toll-like Receptors. The Journal of Biological Chemistry. 2004
  251. Ligand-Stimulated Downregulation of the Alpha Interferon Receptor: Role of Protein Kinase D2. Molecular and Cellular Biology. 2011
  252. Lipopolysaccharide Stimulates p38-dependent Induction of Antiviral Genes in Neutrophils Independently of Paracrine Factors. The Journal of Biological Chemistry. 2003
  253. Lithium Controls Central Nervous System Autoimmunity through Modulation of IFN-γ Signaling. PLoS ONE. 2012
  254. Live Attenuated B. pertussis BPZE1 Rescues the Immune Functions of Respiratory Syncytial Virus Infected Human Dendritic Cells by Promoting Th1/Th17 Responses. PLoS ONE. 2014
  255. Loss of Guanylyl Cyclase C (GCC) Signaling Leads to Dysfunctional Intestinal Barrier. PLoS ONE. 2011
  256. Loss of SOCS3 Gene Expression Converts STAT3 Function from Anti-apoptotic to Pro-apoptotic. The Journal of Biological Chemistry. 2006
  257. Loss of STAT1 in Bone Marrow-Derived Cells Accelerates Skeletal Muscle Regeneration. PLoS ONE. 2012
  258. Luteolin Induces Carcinoma Cell Apoptosis through Binding Hsp90 to Suppress Constitutive Activation of STAT3. PLoS ONE. 2012
  259. Macrophage-specific Up-regulation of Apolipoprotein E Gene Expression by STAT1 Is Achieved via Long Range Genomic Interactions. The Journal of Biological Chemistry. 2011
  260. Mammalian Casein Kinase 1%CE%B1 and Its Leishmanial Ortholog Regulate Stability of IFNAR1 and Type I Interferon Signaling. Molecular and Cellular Biology. 2009
  261. Mechanism of von Hippel-Lindau Protein-Mediated Suppression of Nuclear Factor kappa B Activity. Molecular and Cellular Biology. 2005
  262. Mechanism Underlying Defective Interferon Gamma-Induced IDO Expression in Non-obese Diabetic Mouse Fibroblasts. PLoS ONE. 2012
  263. Mechanisms of Resistance to Interferon-%CE%B3-mediated Cell Growth Arrest in Human Oral Squamous Carcinoma Cells. The Journal of Biological Chemistry. 2009
  264. Mechanisms of STAT Protein Activation by Oncogenic KIT Mutants in Neoplastic Mast Cells. The Journal of Biological Chemistry. 2011
  265. MEK/ERK Dependent Activation of STAT1 Mediates Dasatinib-Induced Differentiation of Acute Myeloid Leukemia. PLoS ONE. 2013
  266. Meta-Analysis Identifies NF-κB as a Therapeutic Target in Renal Cancer. PLoS ONE. 2013
  267. Methylation of the Tumor Suppressor Protein, BRCA1, Influences Its Transcriptional Cofactor Function. PLoS ONE. 2010
  268. MicroRNA-145 Targets YES and STAT1 in Colon Cancer Cells. PLoS ONE. 2010
  269. Minocycline Down-regulates MHC II Expression in Microglia and Macrophages through Inhibition of IRF-1 and Protein Kinase C (PKC)%CE%B1/%CE%B2II. The Journal of Biological Chemistry. 2007
  270. Modification of the Stat1 SH2 Domain Broadly Improves Interferon Efficacy in Proportion to p300/CREB-binding Protein Coactivator Recruitment. The Journal of Biological Chemistry. 2005
  271. Molecular Mechanisms for Synchronized Transcription of Three Complement C1q Subunit Genes in Dendritic Cells and Macrophages. The Journal of Biological Chemistry. 2011
  272. Molecular Regulation of Trypanosoma congolense-Induced Nitric Oxide Production in Macrophages. PLoS ONE. 2013
  273. Morbillivirus V Proteins Exhibit Multiple Mechanisms to Block Type 1 and Type 2 Interferon Signalling Pathways. PLoS ONE. 2013
  274. Mullerian Inhibiting Substance Promotes Interferon %CE%B3-induced Gene Expression and Apoptosis in Breast Cancer Cells. The Journal of Biological Chemistry. 2003
  275. Mutually Positive Regulatory Feedback Loop between Interferons and Estrogen Receptor-α in Mice: Implications for Sex Bias in Autoimmunity. PLoS ONE. 2010
  276. MyD88 and STING Signaling Pathways Are Required for IRF3-Mediated IFN-β Induction in Response to Brucella abortus Infection. PLoS ONE. 2011
  277. NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo. The EMBO Journal. 2010
  278. Negative Regulation of Interferon-β Gene Expression during Acute and Persistent Virus Infections. PLoS ONE. 2011
  279. Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein. The Journal of Biological Chemistry. 2011
  280. NF%CE%BAB Negatively Regulates Interferon-induced Gene Expression and Anti-influenza Activity. The Journal of Biological Chemistry. 2006
  281. NF-%CE%BAB Protects Cells from Gamma Interferon-Induced RIP1-Dependent Necroptosis. Molecular and Cellular Biology. 2011
  282. NF449 Is a Novel Inhibitor of Fibroblast Growth Factor Receptor 3 (FGFR3) Signaling Active in Chondrocytes and Multiple Myeloma Cells. The Journal of Biological Chemistry. 2010
  283. NOTCH1 Up-regulation and Signaling Involved in Mycobacterium bovis BCG-induced SOCS3 Expression in Macrophages. The Journal of Biological Chemistry. 2008
  284. Novel role and mechanism of protein inhibitor of activated STAT1 in spatial learning. The EMBO Journal. 2011
  285. NRAMP-1 Expression Modulates Protein-tyrosine Phosphatase Activity in Macrophages:IMPACT ON HOST CELL SIGNALING AND FUNCTIONS. The Journal of Biological Chemistry. 2007
  286. Nuclear Export Determines the Cytokine Sensitivity of STAT Transcription Factors. The Journal of Biological Chemistry. 2005
  287. Nuclear export signal located within the DNA-binding domain of the STAT1transcription factor. The EMBO Journal. 2000
  288. Nuclear Translocation of Phosphorylated STAT3 Is Essential for Vascular Endothelial Growth Factor-induced Human Dermal Microvascular Endothelial Cell Migration and Tube Formation. The Journal of Biological Chemistry. 2003
  289. Oncolytic Effects of a Novel Influenza A Virus Expressing Interleukin-15 from the NS Reading Frame. PLoS ONE. 2012
  290. Orientation-specific signalling by thrombopoietin receptor dimers. The EMBO Journal. 2011
  291. Osteopontin and Protein Kinase C Regulate PDLIM2 Activation and STAT1 Ubiquitination in LPS-treated Murine Macrophages. The Journal of Biological Chemistry. 2010
  292. Overexpression of REIC/Dkk-3 in Normal Fibroblasts Suppresses Tumor Growth via Induction of Interleukin-7. The Journal of Biological Chemistry. 2009
  293. Oxidative Stress Modulates Complement Factor H Expression in Retinal Pigmented Epithelial Cells by Acetylation of FOXO3. The Journal of Biological Chemistry. 2007
  294. Oxidized Low Density Lipoprotein Blocks Lipopolysaccharide-induced Interferon %CE%B2 Synthesis in Human Macrophages by Interfering with IRF3 Activation. The Journal of Biological Chemistry. 2004
  295. p38 Mitogen-Activated Protein Kinase Mediates the Fas-Induced Mitochondrial Death Pathway in CD8+ T Cells. Molecular and Cellular Biology. 2006
  296. p38 Mitogen-activated Protein Kinase Regulation of JB6 Cl41 Cell Transformation Promoted by Epidermal Growth Factor. The Journal of Biological Chemistry. 2003
  297. P38MAPK-dependent phosphorylation and degradation of SRC-3/AIB1 and RAR[alpha]-mediated transcription. The EMBO Journal. 2006
  298. p38α Mitogen-activated Protein Kinase Sensitizes Cells to Apoptosis Induced by Different Stimuli. Molecular Biology of the Cell. 2004
  299. Palmitoylation of Interferon-%CE%B1 (IFN-%CE%B1) Receptor Subunit IFNAR1 Is Required for the Activation of Stat1 and Stat2 by IFN-%CE%B1. The Journal of Biological Chemistry. 2009
  300. Pan-Bcl-2 Inhibitor AT-101 Enhances Tumor Cell Killing by EGFR Targeted T Cells. PLoS ONE. 2012
  301. Paracrine and Autocrine Functions of Neuronal Vascular Endothelial Growth Factor (VEGF) in the Central Nervous System. The Journal of Biological Chemistry. 2002
  302. PCBP2 Enhances the Antiviral Activity of IFN-α against HCV by Stabilizing the mRNA of STAT1 and STAT2. PLoS ONE. 2011
  303. Peroxisome Proliferator-activated Receptor %CE%B3 Negatively Regulates IFN-%CE%B2 Production in Toll-like Receptor (TLR) 3- and TLR4-stimulated Macrophages by Preventing Interferon Regulatory Factor 3 Binding to the IFN-%CE%B2 Promoter. The Journal of Biological Chemistry. 2011
  304. Phagosomes Induced by Cytokines Function as anti-Listeria Vaccines:NOVEL ROLE FOR FUNCTIONAL COMPARTMENTALIZATION OF STAT-1 PROTEIN AND CATHEPSIN-D. The Journal of Biological Chemistry. 2012
  305. Phenethylisothiocyanate Alters Site- and Promoter-Specific Histone Tail Modifications in Cancer Cells. PLoS ONE. 2013
  306. Phosphodiesterase IV Inhibition by Piclamilast Potentiates the Cytodifferentiating Action of Retinoids in Myeloid Leukemia Cells:CROSS-TALK BETWEEN THE cAMP AND THE RETINOIC ACID SIGNALING PATHWAYS. The Journal of Biological Chemistry. 2004
  307. Phosphotyrosyl Peptides Block Stat3-mediated DNA Binding Activity, Gene Regulation, and Cell Transformation. The Journal of Biological Chemistry. 2001
  308. PLP2 of Mouse Hepatitis Virus A59 (MHV-A59) Targets TBK1 to Negatively Regulate Cellular Type I Interferon Signaling Pathway. PLoS ONE. 2011
  309. Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon %CE%B2. The Journal of Biological Chemistry. 2011
  310. Pomalidomide Shows Significant Therapeutic Activity against CNS Lymphoma with a Major Impact on the Tumor Microenvironment in Murine Models. PLoS ONE. 2013
  311. Potential Biological Functions of Cytochrome P450 Reductase-dependent Enzymes in Small Intestine:NOVEL LINK TO EXPRESSION OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II GENES. The Journal of Biological Chemistry. 2012
  312. Preclinical Evaluation of Engineered Oncolytic Herpes Simplex Virus for the Treatment of Neuroblastoma. PLoS ONE. 2013
  313. Procaspase 8 and Bax Are Up-regulated by Distinct Pathways in Streptococcal Pyrogenic Exotoxin B-induced Apoptosis. The Journal of Biological Chemistry. 2009
  314. Progestins Induce Transcriptional Activation of Signal Transducer and Activator of Transcription 3 (Stat3) via a Jak- and Src-Dependent Mechanism in Breast Cancer Cells. Molecular and Cellular Biology. 2005
  315. Prolactin-induced Cell Proliferation in PC12 Cells Depends on JNK but Not ERK Activation. The Journal of Biological Chemistry. 2000
  316. Protective Role of the Cholinergic Anti-Inflammatory Pathway in a Mouse Model of Viral Myocarditis. PLoS ONE. 2014
  317. Protective Roles of Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) in Dengue Virus Infection of Human Lung Epithelial Cells. PLoS ONE. 2013
  318. Protein Inhibitor of Activated STAT Y (PIASy) and a Splice Variant Lacking Exon 6 Enhance Sumoylation but Are Not Essential for Embryogenesis and Adult Life. Molecular and Cellular Biology. 2004
  319. Protein Kinase C Isoforms %CE%B6 and %CE%B9 Mediate Collagenase Expression and Cartilage Destruction via STAT3- and ERK-dependent c-fos Induction. The Journal of Biological Chemistry. 2010
  320. Protein Kinase C θ Regulates the Phenotype of Murine CD4+ Th17 Cells. PLoS ONE. 2014
  321. Protein Kinase C-%CE%B4 (PKC-%CE%B4) Is Activated by Type I Interferons and Mediates Phosphorylation of Stat1 on Serine 727. The Journal of Biological Chemistry. 2002
  322. Protein Kinase C%CE%B4 Regulates Apoptosis via Activation of STAT1. The Journal of Biological Chemistry. 2004
  323. Protein Tyrosine Phosphatases, TC-PTP, SHP1, and SHP2, Cooperate in Rapid Dephosphorylation of Stat3 in Keratinocytes Following UVB Irradiation. PLoS ONE. 2010
  324. Quantification of the Host Response Proteome after Mammalian Reovirus T1L Infection. PLoS ONE. 2012
  325. Rapid Inhibition of Leptin Signaling by Glucocorticoids in Vitro and in Vivo. The Journal of Biological Chemistry. 2004
  326. Reactive Oxygen Species Mediate Virus-induced STAT Activation:ROLE OF TYROSINE PHOSPHATASES. The Journal of Biological Chemistry. 2004
  327. Receptor Density Is Key to the Alpha2/Beta Interferon Differential Activities. Molecular and Cellular Biology. 2009
  328. Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2. The EMBO Journal. 2006
  329. Recombinant Interleukin-24 Lacks Apoptosis-Inducing Properties in Melanoma Cells. PLoS ONE. 2007
  330. Recombinant p35 from Bacteria Can Form Interleukin (IL-)12, but Not IL-35. PLoS ONE. 2014
  331. Recruitment of Stat4 to the Human Interferon-%CE%B1/%CE%B2 Receptor Requires Activated Stat2. The Journal of Biological Chemistry. 2000
  332. Regulation of c-: myc: expression by IFN-[gamma] through Stat1-dependent and -independent pathways. The EMBO Journal. 2000
  333. Regulation of Erythropoietin-induced STAT Serine Phosphorylation by Distinct Mitogen-activated Protein Kinases. The Journal of Biological Chemistry. 2000
  334. Regulation of Karyopherin %CE%B11 and Nuclear Import by Mammalian Target of Rapamycin. The Journal of Biological Chemistry. 2012
  335. Regulation of STAT1 Nuclear Export by Jak1. Molecular and Cellular Biology. 2000
  336. Regulation of Stat3 Activation by MEK Kinase 1. The Journal of Biological Chemistry. 2001
  337. Requirement of Histone Deacetylase Activity for Signaling by STAT1. The Journal of Biological Chemistry. 2004
  338. Resveratrol Modulates Cytokine-Induced JAK/STAT Activation More Efficiently than 5-Aminosalicylic Acid: An In Vitro Approach. PLoS ONE. 2014
  339. Retinoids inhibit measles virus through a type I IFN-dependent bystander effect. The FASEB Journal. 2009
  340. Rho Family GTPases Are Required for Activation of Jak/STAT Signaling by G Protein-Coupled Receptors. Molecular and Cellular Biology. 2003
  341. RNA-Binding Protein AUF1 Regulates Lipopolysaccharide-Induced IL10 Expression by Activating I%CE%BAB Kinase Complex in Monocytes. Molecular and Cellular Biology. 2011
  342. Role of a JAK3-dependent Biochemical Signaling Pathway in Platelet Activation and Aggregation. The Journal of Biological Chemistry. 2001
  343. Role of CTLA4 in the Proliferation and Survival of Chronic Lymphocytic Leukemia. PLoS ONE. 2013
  344. Role of p38 Protein Kinase in the Ligand-independent Ubiquitination and Down-regulation of the IFNAR1 Chain of Type I Interferon Receptor. The Journal of Biological Chemistry. 2011
  345. Role of STAT3 in Type I Interferon Responses:NEGATIVE REGULATION OF STAT1-DEPENDENT INFLAMMATORY GENE ACTIVATION. The Journal of Biological Chemistry. 2006
  346. Role of the Interleukin (IL)-28 Receptor Tyrosine Residues for Antiviral and Antiproliferative Activity of IL-29/Interferon-%CE%BB1:SIMILARITIES WITH TYPE I INTERFERON SIGNALING. The Journal of Biological Chemistry. 2004
  347. Role of the Stat4 N Domain in Receptor Proximal Tyrosine Phosphorylation. Molecular and Cellular Biology. 2000
  348. Role of Tyrosine 441 of Interferon-%CE%B3 Receptor Subunit 1 in SOCS-1-mediated Attenuation of STAT1 Activation. The Journal of Biological Chemistry. 2005
  349. Roles of Phosphatidylinositol 3-Kinase in Interferon-%CE%B3-dependent Phosphorylation of STAT1 on Serine 727 and Activation of Gene Expression. The Journal of Biological Chemistry. 2001
  350. SCF: HOS: ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-[alpha] receptor. The EMBO Journal. 2003
  351. Secretoglobin 3A2 Suppresses Bleomycin-induced Pulmonary Fibrosis by Transforming Growth Factor %CE%B2 Signaling Down-regulation. The Journal of Biological Chemistry. 2011
  352. SH2 Modified STAT1 Induces HLA-I Expression and Improves IFN-γ Signaling in IFN-α Resistant HCV Replicon Cells. PLoS ONE. 2010
  353. Signal Regulatory Protein %CE%B1 Ligation Induces Macrophage Nitric Oxide Production through JAK/STAT- and Phosphatidylinositol 3-Kinase/Rac1/NAPDH Oxidase/H2O2-Dependent Pathways. Molecular and Cellular Biology. 2005
  354. Signal Transducer and Activator of Transcription-5 Mediates Neuronal Apoptosis Induced by Inhibition of Rac GTPase Activity. The Journal of Biological Chemistry. 2012
  355. Signal Transducers and Activators of Transcription 3 Augments the Transcriptional Activity of CCAAT/Enhancer-binding Protein %CE%B1 in Granulocyte Colony-stimulating Factor Signaling Pathway. The Journal of Biological Chemistry. 2005
  356. Signaling Events Involved in Interleukin 27 (IL-27)-induced Proliferation of Human Naive CD4+ T Cells and B Cells. The Journal of Biological Chemistry. 2011
  357. Signaling Pathways Recruited by the Cardiotrophin-like Cytokine/Cytokine-like Factor-1 Composite Cytokine:SPECIFIC REQUIREMENT OF THE MEMBRANE-BOUND FORM OF CILIARY NEUROTROPHIC FACTOR RECEPTOR %CE%B1 COMPONENT. The Journal of Biological Chemistry. 2001
  358. Silencing Suppressor of Cytokine Signaling-1 (SOCS1) in Macrophages Improves Mycobacterium tuberculosis Control in an Interferon-%CE%B3 (IFN-%CE%B3)-dependent Manner. The Journal of Biological Chemistry. 2011
  359. Simvastatin Impairs Growth Hormone-Activated Signal Transducer and Activator of Transcription (STAT) Signaling Pathway in UMR-106 Osteosarcoma Cells. PLoS ONE. 2014
  360. Site of Pegylation and Polyethylene Glycol Molecule Size Attenuate Interferon-%CE%B1 Antiviral and Antiproliferative Activities through the JAK/STAT Signaling Pathway. The Journal of Biological Chemistry. 2005
  361. Smurf1 Protein Negatively Regulates Interferon-%CE%B3 Signaling through Promoting STAT1 Protein Ubiquitination and Degradation. The Journal of Biological Chemistry. 2012
  362. SOCS-1 Localizes to the Microtubule Organizing Complex-Associated 20S Proteasome. Molecular and Cellular Biology. 2004
  363. SOCS1, SOCS3, and PIAS1 Promote Myogenic Differentiation by Inhibiting the Leukemia Inhibitory Factor-Induced JAK1/STAT1/STAT3 Pathway. Molecular and Cellular Biology. 2009
  364. Specific Inhibition of Interferon Signal Transduction Pathways by Adenoviral Infection. The Journal of Biological Chemistry. 2001
  365. Spermidine Stimulates T Cell Protein-tyrosine Phosphatase-mediated Protection of Intestinal Epithelial Barrier Function. The Journal of Biological Chemistry. 2013
  366. Src Family Kinase-independent Signal Transduction and Gene Induction by Leukemia Inhibitory Factor. The Journal of Biological Chemistry. 2003
  367. Stage Dependent Aberrant Regulation of Cytokine-STAT Signaling in Murine Systemic Lupus Erythematosus. PLoS ONE. 2009
  368. Stat1 as a Component of Tumor Necrosis Factor Alpha Receptor 1-TRADD Signaling Complex To Inhibit NF-%CE%BAB Activation. Molecular and Cellular Biology. 2000
  369. STAT1 Hyperphosphorylation and Defective IL12R/IL23R Signaling Underlie Defective Immunity in Autosomal Dominant Chronic Mucocutaneous Candidiasis. PLoS ONE. 2011
  370. STAT1 Interacts with RXRα to Upregulate ApoCII Gene Expression in Macrophages. PLoS ONE. 2012
  371. Stat1 Nuclear Translocation by Nucleolin upon Monocyte Differentiation. PLoS ONE. 2009
  372. Stat1 Phosphorylation Determines Ras Oncogenicity by Regulating p27Kip1. PLoS ONE. 2008
  373. Stat1-Dependent, p53-Independent Expression of p21waf1 Modulates Oxysterol-Induced Apoptosis. Molecular and Cellular Biology. 2002
  374. STAT1-induced Apoptosis Is Mediated by Caspases 2, 3, and 7. The Journal of Biological Chemistry. 2004
  375. STAT3 Activation by Type I Interferons Is Dependent on Specific Tyrosines Located in the Cytoplasmic Domain of Interferon Receptor Chain 2c:ACTIVATION OF MULTIPLE STATS PROCEEDS THROUGH THE REDUNDANT USAGE OF TWO TYROSINE RESIDUES. The Journal of Biological Chemistry. 2002
  376. STAT3 but Not STAT1 Is Required for Astrocyte Differentiation. PLoS ONE. 2014
  377. STAT3 Contributes to the Mitogenic Response of Hepatocytes during Liver Regeneration. The Journal of Biological Chemistry. 2002
  378. Stat3 Mediates Interelukin-6 Inhibition of Human Endothelial Nitric-oxide Synthase Expression. The Journal of Biological Chemistry. 2006
  379. STAT5 Outcompetes STAT3 To Regulate the Expression of the Oncogenic Transcriptional Modulator BCL6. Molecular and Cellular Biology. 2013
  380. Stimulation of Signal Transducer and Activator of Transcription-1 (STAT1)-dependent Gene Transcription by Lipopolysaccharide and Interferon-%CE%B3 Is Regulated by Mammalian Target of Rapamycin. The Journal of Biological Chemistry. 2003
  381. Stochastic Receptor Expression Determines Cell Fate upon Interferon Treatment. Molecular and Cellular Biology. 2011
  382. Structurally Modified Curcumin Analogs Inhibit STAT3 Phosphorylation and Promote Apoptosis of Human Renal Cell Carcinoma and Melanoma Cell Lines. PLoS ONE. 2012
  383. Structure-Function Correlation of G6, a Novel Small Molecule Inhibitor of Jak2:INDISPENSABILITY OF THE STILBENOID CORE. The Journal of Biological Chemistry. 2010
  384. SUMO Modification of STAT1 and Its Role in PIAS-mediated Inhibition of Gene Activation. The Journal of Biological Chemistry. 2003
  385. Suppression of Apoptosis in the Protein Kinase C%CE%B4 Null Mouse in Vivo. The Journal of Biological Chemistry. 2006
  386. Suppression of Interferon (IFN)-inducible Genes and IFN-mediated Functional Responses in BCR-ABL-expressing Cells. The Journal of Biological Chemistry. 2008
  387. Suppressor of cytokine signaling 1 (SOCS1) limits NFκB signaling by decreasing p65 stability within the cell nucleus. The FASEB Journal. 2011
  388. Suppressor of Cytokine Signaling-1 Attenuates the Duration of Interferon %CE%B3 Signal Transduction in Vitro and in Vivo. The Journal of Biological Chemistry. 2001
  389. Sutherlandia frutescens Ethanol Extracts Inhibit Oxidative Stress and Inflammatory Responses in Neurons and Microglial Cells. PLoS ONE. 2014
  390. Synergistic Transcriptional Activation of HumanAcyl-coenzyme A: Cholesterol Acyltransterase-1 Gene by Interferon-%CE%B3 and All-trans-Retinoic Acid THP-1 Cells. The Journal of Biological Chemistry. 2001
  391. T Cell-Intrinsic and -Extrinsic Contributions of the IFNAR/STAT1-Axis to Thymocyte Survival. PLoS ONE. 2011
  392. Telomere Length Influences Cancer Cell Differentiation In Vivo. Molecular and Cellular Biology. 2013
  393. TGF-β Enhanced IL-21-Induced Differentiation of Human IL-21-Producing CD4+ T Cells via Smad3. PLoS ONE. 2013
  394. The Angiotensin II-dependent Nuclear Translocation of Stat1 Is Mediated by the Jak2 Protein Motif231YRFRR. The Journal of Biological Chemistry. 2001
  395. The C Proteins of Human Parainfluenza Virus Type 1 Block IFN Signaling by Binding and Retaining Stat1 in Perinuclear Aggregates at the Late Endosome. PLoS ONE. 2011
  396. The Catalytic Activity of the Eukaryotic Initiation Factor-2%CE%B1 Kinase PKR Is Required to Negatively Regulate Stat1 and Stat3 via Activation of the T-cell Protein-tyrosine Phosphatase. The Journal of Biological Chemistry. 2006
  397. The Comparative Roles of Suppressor of Cytokine Signaling-1 and -3 in the Inhibition and Desensitization of Cytokine Signaling. The Journal of Biological Chemistry. 2006
  398. The Conserved Leu-724 Residue Is Required for Both Serine Phosphorylation and Co-activator Recruitment for Stat1-mediated Transcription Activation in Response to Interferon-%CE%B3. The Journal of Biological Chemistry. 2005
  399. The Fanconi Anemia Protein FANCC Binds to and Facilitates the Activation of STAT1 by Gamma Interferon and Hematopoietic Growth Factors. Molecular and Cellular Biology. 2000
  400. The Heat Shock Protein 90-CDC37 Chaperone Complex Is Required for Signaling by Types I and II Interferons. The Journal of Biological Chemistry. 2006
  401. The highly virulent variola and monkeypox viruses express secreted inhibitors of type I interferon. The FASEB Journal. 2010
  402. The HIV Matrix Protein p17 Promotes the Activation of Human Hepatic Stellate Cells through Interactions with CXCR2 and Syndecan-2. PLoS ONE. 2014
  403. The HIV Matrix Protein p17 Subverts Nuclear Receptors Expression and Induces a STAT1-Dependent Proinflammatory Phenotype in Monocytes. PLoS ONE. 2012
  404. The Inhibition of Interleukin-6-dependent STAT Activation by Mitogen-activated Protein Kinases Depends on Tyrosine 759 in the Cytoplasmic Tail of Glycoprotein 130. The Journal of Biological Chemistry. 2000
  405. The Jak1 SH2 Domain Does Not Fulfill a Classical SH2 Function in Jak/STAT Signaling but Plays a Structural Role for Receptor Interaction and Up-regulation of Receptor Surface Expression. The Journal of Biological Chemistry. 2005
  406. The Kinase Activity of Fibroblast Growth Factor Receptor 3 with Activation Loop Mutations Affects Receptor Trafficking and Signaling. The Journal of Biological Chemistry. 2004
  407. The Low Density Lipoprotein Receptor-related Protein Is a Motogenic Receptor for Plasminogen Activator Inhibitor-1. The Journal of Biological Chemistry. 2004
  408. The Macrophage Cholesterol Exporter ABCA1 Functions as an Anti-inflammatory Receptor. The Journal of Biological Chemistry. 2009
  409. The Minichromosome Maintenance Proteins 2-7 (MCM2-7) Are Necessary for RNA Polymerase II (Pol II)-mediated Transcription. The Journal of Biological Chemistry. 2009
  410. The Oncogenic Fusion Protein-tyrosine Kinase ZNF198/Fibroblast Growth Factor Receptor-1 Has Signaling Function Comparable with Interleukin-6 Cytokine Receptors. The Journal of Biological Chemistry. 2003
  411. The p38 MAPK Pathway Mediates the Growth Inhibitory Effects of Interferon-%CE%B1 in BCR-ABL-expressing Cells. The Journal of Biological Chemistry. 2001
  412. The Proinflammatory Cytokine, Interleukin-6, Up-regulates Calcium-sensing Receptor Gene Transcription via Stat1/3 and Sp1/3. The Journal of Biological Chemistry. 2008
  413. The Rac1/p38 Mitogen-activated Protein Kinase Pathway Is Required for Interferon %CE%B1-dependent Transcriptional Activation but Not Serine Phosphorylation of Stat Proteins. The Journal of Biological Chemistry. 2000
  414. The Serine Protease Plasmin Triggers Expression of MCP-1 and CD40 in Human Primary Monocytes via Activation of p38 MAPK and Janus Kinase (JAK)/STAT Signaling Pathways. The Journal of Biological Chemistry. 2002
  415. The Stability of the Ternary Interferon-Receptor Complex Rather than the Affinity to the Individual Subunits Dictates Differential Biological Activities. The Journal of Biological Chemistry. 2008
  416. The Stat3-activating Tyk2 V678F Mutant Does Not Up-regulate Signaling through the Type I Interferon Receptor but Confers Ligand Hypersensitivity to a Homodimeric Receptor. The Journal of Biological Chemistry. 2008
  417. The T-cell Lymphokine Interleukin-26 Targets Epithelial Cells through the Interleukin-20 Receptor 1 and Interleukin-10 Receptor 2 Chains. The Journal of Biological Chemistry. 2004
  418. The Thanatophoric Dysplasia Type II Mutation Hampers Complete Maturation of Fibroblast Growth Factor Receptor 3 (FGFR3), Which Activates Signal Transducer and Activator of Transcription 1 (STAT1) from the Endoplasmic Reticulum. The Journal of Biological Chemistry. 2003
  419. The Transcription Factor C/EBP delta Has Anti-Apoptotic and Anti-Inflammatory Roles in Pancreatic Beta Cells. PLoS ONE. 2012
  420. The Transcriptional Coactivator CREB-binding Protein Cooperates with STAT1 and NF-%CE%BAB for Synergistic Transcriptional Activation of the CXC Ligand 9/Monokine Induced by Interferon-%CE%B3 Gene. The Journal of Biological Chemistry. 2003
  421. The Transcriptional Co-activator Protein p100 Recruits Histone Acetyltransferase Activity to STAT6 and Mediates Interaction between the CREB-binding Protein and STAT6. The Journal of Biological Chemistry. 2005
  422. The Type I Interferon Signaling Pathway Is a Target for Glucocorticoid Inhibition. Molecular and Cellular Biology. 2010
  423. The Tyrosine Kinase c-Src Enhances RIG-I (Retinoic Acid-inducible Gene I)-elicited Antiviral Signaling. The Journal of Biological Chemistry. 2009
  424. The ubiquitin hydrolase USP22 contributes to 3′-end processing of JAK-STAT-inducible genes. The FASEB Journal. 2012
  425. The V Protein of Tioman Virus Is Incapable of Blocking Type I Interferon Signaling in Human Cells. PLoS ONE. 2013
  426. The V Protein of Tioman Virus Is Incapable of Blocking Type I Interferon Signaling in Human Cells. PLoS ONE. 2012
  427. The Vitamin D Receptor Agonist BXL-01-0029 as a Potential New Pharmacological Tool for the Treatment of Inflammatory Myopathies. PLoS ONE. 2013
  428. Therapeutic Gene Silencing Delivered by a Chemically Modified Small Interfering RNA against Mutant SOD1 Slows Amyotrophic Lateral Sclerosis Progression. The Journal of Biological Chemistry. 2008
  429. Thrombin Inhibits Tumor Cell Growth in Association with Up-regulation of p21 waf/cip1 and Caspases via a p53-independent, STAT-1-dependent Pathway. The Journal of Biological Chemistry. 2000
  430. Thrombin Regulates Vascular Smooth Muscle Cell Growth and Heat Shock Proteins via the JAK-STAT Pathway. The Journal of Biological Chemistry. 2001
  431. Tid1 Isoforms Are Mitochondrial DnaJ-like Chaperones with Unique Carboxyl Termini That Determine Cytosolic Fate. The Journal of Biological Chemistry. 2006
  432. Timing Is Critical for an Effective Anti-Metastatic Immunotherapy: The Decisive Role of IFNγ/STAT1-Mediated Activation of Autophagy. PLoS ONE. 2011
  433. TLR-9 Contributes to the Antiviral Innate Immune Sensing of Rodent Parvoviruses MVMp and H-1PV by Normal Human Immune Cells. PLoS ONE. 2013
  434. TLR-9 Contributes to the Antiviral Innate Immune Sensing of Rodent Parvoviruses MVMp and H-1PV by Normal Human Immune Cells. PLoS ONE. 2012
  435. Toll-like Receptor-dependent and -independent Viperin Gene Expression and Counter-regulation by PRDI-binding Factor-1/BLIMP1. The Journal of Biological Chemistry. 2006
  436. Toll-like Receptors 2 and 4 Activate STAT1 Serine Phosphorylation by Distinct Mechanisms in Macrophages. The Journal of Biological Chemistry. 2003
  437. Toxoplasma gondii Triggers Phosphorylation and Nuclear Translocation of Dendritic Cell STAT1 while Simultaneously Blocking IFNγ-Induced STAT1 Transcriptional Activity. PLoS ONE. 2013
  438. TRBP Control of PACT-Induced Phosphorylation of Protein Kinase R Is Reversed by Stress. Molecular and Cellular Biology. 2009
  439. Tripartite Motif 24 (Trim24/Tif1%CE%B1) Tumor Suppressor Protein Is a Novel Negative Regulator of Interferon (IFN)/Signal Transducers and Activators of Transcription (STAT) Signaling Pathway Acting through Retinoic Acid Receptor %CE%B1 (Rar%CE%B1) Inhibition. The Journal of Biological Chemistry. 2011
  440. Tristetraprolin Mediates Anti-inflammatory Effects of Nicotine in Lipopolysaccharide-stimulated Macrophages. The Journal of Biological Chemistry. 2011
  441. Tristetraprolin-dependent Post-transcriptional Regulation of Inflammatory Cytokine mRNA Expression by Apolipoprotein A-I:ROLE OF ATP-BINDING MEMBRANE CASSETTE TRANSPORTER A1 AND SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3. The Journal of Biological Chemistry. 2011
  442. Trypanosoma cruzi Evades the Protective Role of Interferon-Gamma-Signaling in Parasite-Infected Cells. PLoS ONE. 2014
  443. Tumor Necrosis Factor %CE%B1 Modulates Airway Smooth Muscle Function via the Autocrine Action of Interferon %CE%B2. The Journal of Biological Chemistry. 2003
  444. Tumor STAT1 Transcription Factor Activity Enhances Breast Tumor Growth and Immune Suppression Mediated by Myeloid-derived Suppressor Cells. The Journal of Biological Chemistry. 2013
  445. Tumor suppressor IRF-1 mediates retinoid and interferon anticancer signaling to death ligand TRAIL. The EMBO Journal. 2004
  446. Two Discrete Promoters Regulate the Alternatively Spliced Human Interferon Regulatory Factor-5 Isoforms:MULTIPLE ISOFORMS WITH DISTINCT CELL TYPE-SPECIFIC EXPRESSION, LOCALIZATION, REGULATION, AND FUNCTION. The Journal of Biological Chemistry. 2005
  447. Two Independent Mechanisms Promote Expression of an N-terminal Truncated USP18 Isoform with Higher DeISGylation Activity in the Nucleus. The Journal of Biological Chemistry. 2012
  448. TYK2 and JAK2 Are Substrates of Protein-tyrosine Phosphatase 1B. The Journal of Biological Chemistry. 2001
  449. Tyk2 Tyrosine Kinase Expression Is Required for the Maintenance of Mitochondrial Respiration in Primary Pro-B Lymphocytes. Molecular and Cellular Biology. 2006
  450. Type I Interferon: Potential Therapeutic Target for Psoriasis?. PLoS ONE. 2008
  451. Type I Interferons and Interferon Regulatory Factors Regulate TNF-Related Apoptosis-Inducing Ligand (TRAIL) in HIV-1-Infected Macrophages. PLoS ONE. 2009
  452. Tyrosine Phosphorylation of Protein Kinase D2 Mediates Ligand-inducible Elimination of the Type 1 Interferon Receptor. The Journal of Biological Chemistry. 2011
  453. Ube1L and Protein ISGylation Are Not Essential for Alpha/Beta Interferon Signaling. Molecular and Cellular Biology. 2006
  454. Up-regulation and Sustained Activation of Stat1 Are Essential for Interferon-%CE%B3 (IFN-%CE%B3)-induced Dual Oxidase 2 (Duox2) and Dual Oxidase A2 (DuoxA2) Expression in Human Pancreatic Cancer Cell Lines. The Journal of Biological Chemistry. 2011
  455. Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-[beta]. The EMBO Journal. 2005
  456. Vanadate Facilitates Interferon %CE%B1-mediated Apoptosis That Is Dependent on the Jak/Stat Pathway. The Journal of Biological Chemistry. 2001
  457. Viral Induction of the Zinc Finger Antiviral Protein Is IRF3-dependent but NF-%CE%BAB-independent. The Journal of Biological Chemistry. 2010
  458. Virus Infection Triggers SUMOylation of IRF3 and IRF7, Leading to the Negative Regulation of Type I Interferon Gene Expression. The Journal of Biological Chemistry. 2008
  459. Wedelolactone, a Naturally Occurring Coumestan, Enhances Interferon-%CE%B3 Signaling through Inhibiting STAT1 Protein Dephosphorylation. The Journal of Biological Chemistry. 2013
  460. Whole Proteome Analysis of Mouse Lymph Nodes in Cutaneous Anthrax. PLoS ONE. 2014
  461. WSX1 Expression in Tumors Induces Immune Tolerance via Suppression of Effector Immune Cells. PLoS ONE. 2011
  462. Yohimbine Enhances Protection of Berberine against LPS-Induced Mouse Lethality through Multiple Mechanisms. PLoS ONE. 2012
  463. Zoledronic Acid Enhances Lipopolysaccharide-Stimulated Proinflammatory Reactions through Controlled Expression of SOCS1 in Macrophages. PLoS ONE. 2013
  464. Zoledronic Acid Sensitizes Renal Cell Carcinoma Cells to Radiation by Downregulating STAT1. PLoS ONE. 2013

 

ERK1: Research Trend, Expert Distribution, and Antibody Citation

ERK1, encoded by MAPK3 mitogen-activated protein kinase 3 (MAPK3) also known as ERT2; ERK-1; PRKM3; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK. ERK1 is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [1-6]

Fig 1. ERK1 Research Distribution. Institutions are ranked by number of related projects.

Fig 1. ERK1 Research Distribution. Institutions are ranked by number of related projects.

Research Overview

In the past 16 years, ERK1 research has been conducted in 614 research groups from 226 institutions in the United States. The accumulated number of projects: 2,217, and funding: $ 643 million.

 

Fig 2. Research Trend of ERK1 by annual NIH project number, funding, and NIH PI.

Fig 2. Research Trend of ERK1 by annual NIH project number, funding, and NIH PI.

 

Antibody Citation

ERK1 accounts for 2.3% of all publications in the past 15 years. 68 manufacturers have produced ERK1 antibody with citations appearing in peer review publications. The top suppliers are Cell Signaling Technology and Santa Cruz, accounting for around 80% of total citations. The annual citation trend are summarized below.

 

Fig 3. ERK1 Antibody Citation breakdown. Total citations from all providers from all years (2000-2014) are included.

Fig 3. ERK1 Antibody Citation breakdown. Total citations from all providers from all years (2000-2014) are included.

Fig 4

Fig 4. ERK1 Antibody Citation Trend: Annual product citation trend from each provider.

 

Closing Remarks:

This snapshot features a quantitative analysis for ERK1 research, and a cross-vendor comparison for ERK1 antibody manufacturers. It is aimed to provide a top-down perspective to deepen our understanding for ERK1; and an unbiased comparison for rational selection of ERK1 antibody. The complete list of publications found with ERK1 antibody citation from major open source publications can be viewed in ERK1 antibody comparison module.

 

Reference:

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  4. Prolonged survival after neoadjuvant chemotherapy related with specific molecular alterations in the patients with nonsmall-cell lung carcinoma. Stojsic J, et al. Exp Mol Pathol, 2015
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  23. 15-Lipoxygenase-1 Metabolites Down-regulate Peroxisome Proliferator-activated Receptor %CE%B3 via the MAPK Signaling Pathway. The Journal of Biological Chemistry. 2001
  24. 18β-Glycyrrhetinic Acid Suppresses Cell Proliferation through Inhibiting Thromboxane Synthase in Non-Small Cell Lung Cancer. PLoS ONE. 2014
  25. 2,2′-Diphenyl-3,3′-Diindolylmethane: A Potent Compound Induces Apoptosis in Breast Cancer Cells by Inhibiting EGFR Pathway. PLoS ONE. 2013
  26. 20-Hydroxyeicosatetraenoic Acid Impairs Endothelial Insulin Signaling by Inducing Phosphorylation of the Insulin Receptor Substrate-1 at Ser616. PLoS ONE. 2014
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  30. A Brain-specific Grb2-associated Regulator of Extracellular Signal-regulated Kinase (Erk)/Mitogen-activated Protein Kinase (MAPK) (GAREM) Subtype, GAREM2, Contributes to Neurite Outgrowth of Neuroblastoma Cells by Regulating Erk Signaling. The Journal of Biological Chemistry. 2013
  31. A Calcineurin Docking Motif (LXVP) in Dynamin-related Protein 1 Contributes to Mitochondrial Fragmentation and Ischemic Neuronal Injury. The Journal of Biological Chemistry. 2013
  32. A Calcium/Calmodulin-dependent Activation of ERK1/2 Mediates JunD Phosphorylation and Induction of nur77 and20%CE%B1-hsd Genes by Prostaglandin F2%CE%B1 in Ovarian Cells. The Journal of Biological Chemistry. 2002
  33. A Conserved Motif for the Transport of G Protein-coupled Receptors from the Endoplasmic Reticulum to the Cell Surface. The Journal of Biological Chemistry. 2004
  34. A Constituent of Green Tea, Epigallocatechin-3-gallate, Activates Endothelial Nitric Oxide Synthase by a Phosphatidylinositol-3-OH-kinase-, cAMP-dependent Protein Kinase-, and Akt-dependent Pathway and Leads to Endothelial-dependent Vasorelaxation. The Journal of Biological Chemistry. 2004
  35. A Critical Role of Tropomyosins in TGF-β Regulation of the Actin Cytoskeleton and Cell Motility in Epithelial Cells. Molecular Biology of the Cell. 2004
  36. A Differential Role for the Mitogen-activated Protein Kinases in Lipopolysaccharide Signaling:THE MEK/ERK PATHWAY IS NOT ESSENTIAL FOR NITRIC OXIDE AND INTERLEUKIN 1%CE%B2 PRODUCTION. The Journal of Biological Chemistry. 2002
  37. A Direct Interaction between Oncogenic Ha-Ras and Phosphatidylinositol 3-Kinase Is Not Required for Ha-Ras-dependent Transformation of Epithelial Cells. The Journal of Biological Chemistry. 2001
  38. A Gain of Function Mutation in the Activation Loop of Plateletderived Growth Factor %CE%B2-Receptor Deregulates Its Kinase Activity. The Journal of Biological Chemistry. 2004
  39. A Genome-Wide Screen of CREB Occupancy Identifies the RhoA Inhibitors Par6C and Rnd3 as Regulators of BDNF-Induced Synaptogenesis. PLoS ONE. 2013
  40. A GNAS Mutation Found in Pancreatic Intraductal Papillary Mucinous Neoplasms Induces Drastic Alterations of Gene Expression Profiles with Upregulation of Mucin Genes. PLoS ONE. 2014
  41. A Linear Signal Transduction Pathway Involving Phosphatidylinositol 3-Kinase, Protein Kinase C%CF%B5, and MAPK in Mesangial Cells Regulates Interferon-%CE%B3-induced STAT1%CE%B1 Transcriptional Activation. The Journal of Biological Chemistry. 2004
  42. A Mutant Form of JAB/SOCS1 Augments the Cytokine-induced JAK/STAT Pathway by Accelerating Degradation of Wild-type JAB/CIS Family Proteins through the SOCS-box. The Journal of Biological Chemistry. 2001
  43. A Network of Immediate Early Gene Products Propagates Subtle Differences in Mitogen-Activated Protein Kinase Signal Amplitude and Duration. Molecular and Cellular Biology. 2004
  44. A Network Pharmacology Study of Chinese Medicine QiShenYiQi to Reveal Its Underlying Multi-Compound, Multi-Target, Multi-Pathway Mode of Action. PLoS ONE. 2014
  45. A Novel Aminothiazole KY-05009 with Potential to Inhibit Traf2- and Nck-Interacting Kinase (TNIK) Attenuates TGF-β1-Mediated Epithelial-to-Mesenchymal Transition in Human Lung Adenocarcinoma A549 Cells. PLoS ONE. 2014
  46. A novel function for the Tec family tyrosine kinase Itk in activation of [beta]1 integrins by the T-cell receptor. The EMBO Journal. 2001
  47. A Novel Herbal Medicine, KIOM-C, Induces Autophagic and Apoptotic Cell Death Mediated by Activation of JNK and Reactive Oxygen Species in HT1080 Human Fibrosarcoma Cells. PLoS ONE. 2014
  48. A Novel Human Phosphatidylethanolamine-binding Protein Resists Tumor Necrosis Factor %CE%B1-induced Apoptosis by Inhibiting Mitogen-activated Protein Kinase Pathway Activation and Phosphatidylethanolamine Externalization. The Journal of Biological Chemistry. 2004
  49. A Novel Hydrogen Peroxide-induced Phosphorylation and Ubiquitination Pathway Leading to RNA Polymerase II Proteolysis. The Journal of Biological Chemistry. 2004
  50. A Novel Interaction between hScrib and PP1γ Downregulates ERK Signaling and Suppresses Oncogene-Induced Cell Transformation. PLoS ONE. 2013
  51. A Novel Interleukin-17 Receptor-like Protein Identified in Human Umbilical Vein Endothelial Cells Antagonizes Basic Fibroblast Growth Factor-induced Signaling. The Journal of Biological Chemistry. 2003
  52. A Novel mTOR-Regulated Phosphorylation Site in Elongation Factor 2 Kinase Modulates the Activity of the Kinase and Its Binding to Calmodulin. Molecular and Cellular Biology. 2004
  53. A Novel NF-%CE%BAB-inducing Kinase-MAPK Signaling Pathway Up-regulates NF-%CE%BAB Activity in Melanoma Cells. The Journal of Biological Chemistry. 2002
  54. A Novel Protein-Protein Interaction between a G Protein-coupled Receptor and the Phosphatase SHP-2 Is Involved in Bradykinin-induced Inhibition of Cell Proliferation. The Journal of Biological Chemistry. 2002
  55. A Novel Role for Adipose Ephrin-B1 in Inflammatory Response. PLoS ONE. 2013
  56. A Novel Role for the Adaptor Molecule CD2-associated Protein in Transforming Growth Factor-%CE%B2-induced Apoptosis. The Journal of Biological Chemistry. 2004
  57. A Novel Signaling Pathway Mediates the Inhibition of CCL3/4 Expression by Prostaglandin E2. The Journal of Biological Chemistry. 2004
  58. A Novel Tumor Suppressor Function of Glycine N-Methyltransferase Is Independent of Its Catalytic Activity but Requires Nuclear Localization. PLoS ONE. 2013
  59. A novel vasopressin-induced transcript promotes MAP kinase activation and ENaC downregulation. The EMBO Journal. 2002
  60. A Pathophysiologic Role for Epidermal Growth Factor Receptor in Pemphigus Acantholysis. The Journal of Biological Chemistry. 2013
  61. A Positive Feedback Loop between Glycogen Synthase Kinase 3%CE%B2 and Protein Phosphatase 1 after Stimulation of NR2B NMDA Receptors in Forebrain Neurons. The Journal of Biological Chemistry. 2005
  62. A reinvestigation of the multisite phosphorylation of the transcription factor c-Jun. The EMBO Journal. 2003
  63. A Role for Mitogen-activated Protein KinaseErk1/2 Activation and Non-selective Pore Formation in P2X7 Receptor-mediated Thymocyte Death. The Journal of Biological Chemistry. 2005
  64. A Role for the Extracellular Signal-regulated Kinase and p38 Mitogen-activated Protein Kinases in Interleukin-1%CE%B2-stimulated Delayed Signal Tranducer and Activator of Transcription 3 Activation, Atrial Natriuretic Factor Expression, and Cardiac Myocyte Morphology. The Journal of Biological Chemistry. 2001
  65. A Ser252Trp Mutation in Fibroblast Growth Factor Receptor 2 (FGFR2) Mimicking Human Apert Syndrome Reveals an Essential Role for FGF Signaling in the Regulation of Endochondral Bone Formation. PLoS ONE. 2014
  66. A Single Amino Acid Substitution Converts a Transmembrane Protein Activator of the Platelet-derived Growth Factor %CE%B2 Receptor into an Inhibitor. The Journal of Biological Chemistry. 2013
  67. A Truncated Kringle Domain of Human Apolipoprotein(a) Inhibits the Activation of Extracellular Signal-regulated Kinase 1 and 2 through a Tyrosine Phosphatase-dependent Pathway. The Journal of Biological Chemistry. 2004
  68. A Unifying Mechanism for Cancer Cell Death through Ion Channel Activation by HAMLET. PLoS ONE. 2013
  69. Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-[kappa]B. The EMBO Journal. 2002
  70. Absence of Cardiovascular Manifestations in a Haploinsufficient Tgfbr1 Mouse Model. PLoS ONE. 2014
  71. Acidic Extracellular pH Induces Vascular Endothelial Growth Factor (VEGF) in Human Glioblastoma Cells via ERK1/2 MAPK Signaling Pathway:MECHANISM OF LOW pH-INDUCED VEGF. The Journal of Biological Chemistry. 2002
  72. AcSDKP Regulates Cell Proliferation through the PI3KCA/Akt Signaling Pathway. PLoS ONE. 2013
  73. Actin Cytoskeletal Architecture Regulates Nitric Oxide-induced Apoptosis, Dedifferentiation, and Cyclooxygenase-2 Expression in Articular Chondrocytes via Mitogen-activated Protein Kinase and Protein Kinase C Pathways. The Journal of Biological Chemistry. 2003
  74. Activation Associated ERK1/2 Signaling Impairments in CD8+ T Cells Co-Localize with Blunted Polyclonal and HIV-1 Specific Effector Functions in Early Untreated HIV-1 Infection. PLoS ONE. 2013
  75. Activation of AMPKα2 Is Not Crucial for Mitochondrial Uncoupling-Induced Metabolic Effects but Required to Maintain Skeletal Muscle Integrity. PLoS ONE. 2014
  76. Activation of Constitutive Nitric-oxide Synthase Activity Is an Early Signaling Event Induced by Ionizing Radiation. The Journal of Biological Chemistry. 2002
  77. Activation of Go-coupled Dopamine D2 Receptors Inhibits ERK1/ERK2 in Pituitary Cells:A KEY STEP IN THE TRANSCRIPTIONAL SUPPRESSION OF THE PROLACTIN GENE. The Journal of Biological Chemistry. 2002
  78. Activation of JNK1, RSK2, and MSK1 Is Involved in Serine 112 Phosphorylation of Bad by Ultraviolet B Radiation. The Journal of Biological Chemistry. 2002
  79. Activation of MAPK and FoxO by Manganese (Mn) in Rat Neonatal Primary Astrocyte Cultures. PLoS ONE. 2014
  80. Activation of MAPKs by Angiotensin II in Vascular Smooth Muscle Cells:METALLOPROTEASE-DEPENDENT EGF RECEPTOR ACTIVATION IS REQUIRED FOR ACTIVATION OF ERK AND p38 MAPK BUT NOT FOR JNK. The Journal of Biological Chemistry. 2001
  81. Activation of Mesenchymal Stem Cells by Macrophages Prompts Human Gastric Cancer Growth through NF-κB Pathway. PLoS ONE. 2014
  82. Activation of Na+/H+ Exchanger-directed Protein Kinases in the Ischemic and Ischemic-reperfused Rat Myocardium. The Journal of Biological Chemistry. 2001
  83. Activation of NF-%CE%BAB Is Essential for Hepatocyte Growth Factor-Mediated Proliferation and Tubulogenesis. Molecular and Cellular Biology. 2002
  84. Activation of Raf/MEK/ERK/cPLA2 Signaling Pathway Is Essential for Chlamydial Acquisition of Host Glycerophospholipids. The Journal of Biological Chemistry. 2004
  85. Activation of the ERK1/2 Signaling Pathway Promotes Phosphorylation and Proteasome-dependent Degradation of the BH3-only Protein, Bim. The Journal of Biological Chemistry. 2003
  86. Activation of the PI3K/mTOR Pathway Is Involved in Cystic Proliferation of Cholangiocytes of the PCK Rat. PLoS ONE. 2014
  87. Activation of the Prolyl Hydroxylase Oxygen-sensor Results in Induction of GLUT1, Heme Oxygenase-1, and Nitric-oxide Synthase Proteins and Confers Protection from Metabolic Inhibition to Cardiomyocytes. The Journal of Biological Chemistry. 2003
  88. Activator Protein-1 Transcription Factor Mediates Bombesin-stimulated Cyclooxygenase-2 Expression in Intestinal Epithelial Cells. The Journal of Biological Chemistry. 2001
  89. Adenosine Nucleotides Acting at the Human P2Y1Receptor Stimulate Mitogen-activated Protein Kinases and Induce Apoptosis. The Journal of Biological Chemistry. 2001
  90. Adhesion-dependent Activation of the ERK1/2 Cascade Is By-passed in Melanoma Cells. The Journal of Biological Chemistry. 2003
  91. Adhesion-related Kinase Repression of Gonadotropin-releasing Hormone Gene Expression Requires Rac Activation of the Extracellular Signal-regulated Kinase Pathway. The Journal of Biological Chemistry. 2002
  92. Adiponectin Regulates Vascular Endothelial Growth Factor-C Expression in Macrophages via Syk-ERK Pathway. PLoS ONE. 2013
  93. Administration of Reconstituted Polyphenol Oil Bodies Efficiently Suppresses Dendritic Cell Inflammatory Pathways and Acute Intestinal Inflammation. PLoS ONE. 2014
  94. Advanced Glycation Endproducts Interfere with Adhesion and Neurite Outgrowth. PLoS ONE. 2014
  95. Agonist-dependent Signaling by Group I Metabotropic Glutamate Receptors Is Regulated by Association with Lipid Domains. The Journal of Biological Chemistry. 2013
  96. Agonist-induced Signaling, Desensitization, and Internalization of a Phosphorylation-deficient AT1A Angiotensin Receptor. The Journal of Biological Chemistry. 2001
  97. A-Kinase Anchoring Protein Lbc Coordinates a p38 Activating Signaling Complex Controlling Compensatory Cardiac Hypertrophy. Molecular and Cellular Biology. 2013
  98. Akt Mediates Insulin-stimulated Phosphorylation of Ndrg2:EVIDENCE FOR CROSS-TALK WITH PROTEIN KINASE C %CE%B8. The Journal of Biological Chemistry. 2004
  99. Akt Mediates Ras Downregulation of RhoB, a Suppressor of Transformation, Invasion, and Metastasis. Molecular and Cellular Biology. 2004
  100. Akt Serine Threonine Kinase Regulates Platelet-derived Growth Factor-induced DNA Synthesis in Glomerular Mesangial Cells:REGULATION OF c-fos AND p27%0Akip1%0A GENE EXPRESSION%0A. The Journal of Biological Chemistry. 2001
  101. Akt/PKB Activity Is Required for Ha-Ras-mediated Transformation of Intestinal Epithelial Cells. The Journal of Biological Chemistry. 2001
  102. AKT2 Inhibition of Cisplatin-induced JNK/p38 and Bax Activation by Phosphorylation of ASK1:IMPLICATION OF AKT2 IN CHEMORESISTANCE. The Journal of Biological Chemistry. 2003
  103. Alteration in Mir-21/PTEN Expression Modulates Gefitinib Resistance in Non-Small Cell Lung Cancer. PLoS ONE. 2014
  104. Alteration of Mesodermal Cell Differentiation by EWS/FLI-1, the Oncogene Implicated in Ewing’s Sarcoma. Molecular and Cellular Biology. 2003
  105. Alteration of Skin Wound Healing in Keratinocyte-Specific Mediator Complex Subunit 1 Null Mice. PLoS ONE. 2014
  106. Altered Extracellular Signal-Regulated Kinase Signaling and Glycogen Metabolism in Skeletal Muscle from p90 Ribosomal S6 Kinase 2 Knockout Mice. Molecular and Cellular Biology. 2001
  107. Altered Insulin Signaling in Retinal Tissue in Diabetic States. The Journal of Biological Chemistry. 2004
  108. Altered nitric oxide production mediates matrix-specific PAK2 and NF-κB activation by flow. Molecular Biology of the Cell. 2013
  109. Altered Protease–Activated Receptor-1 Expression and Signaling in a Malignant Pleural Mesothelioma Cell Line, NCI-H28, with Homozygous Deletion of the β-Catenin Gene. PLoS ONE. 2014
  110. Alternate FGF2-ERK1/2 Signaling Pathways in Retinal Photoreceptor and Glial Cells in Vitro. The Journal of Biological Chemistry. 2001
  111. Alternative Signaling Pathways as Potential Therapeutic Targets for Overcoming EGFR and c-Met Inhibitor Resistance in Non-Small Cell Lung Cancer. PLoS ONE. 2013
  112. Alternative, Nonapoptotic Programmed Cell Death:MEDIATION BY ARRESTIN 2, ERK2, AND Nur77. The Journal of Biological Chemistry. 2004
  113. Amino Acids Interfere with the ERK1/2-dependent Control of Macroautophagy by Controlling the Activation of Raf-1 in Human Colon Cancer HT-29 Cells. The Journal of Biological Chemistry. 2003
  114. An angiogenic laminin site and its antagonist bind through the αvβ3 and α5β1 integrins. The FASEB Journal. 2001
  115. An Apoptotic Signaling Pathway in the Interferon Antiviral Response Mediated by RNase L and c-Jun NH2-terminal Kinase. The Journal of Biological Chemistry. 2004
  116. An Interaction of Renin-Angiotensin and Kallikrein-Kinin Systems Contributes to Vascular Hypertrophy in Angiotensin II-Induced Hypertension: In Vivo and In Vitro Studies. PLoS ONE. 2014
  117. Analysis of %CE%B3c-Family Cytokine Target Genes:IDENTIFICATION OF DUAL-SPECIFICITY PHOSPHATASE 5 (DUSP5) AS A REGULATOR OF MITOGEN-ACTIVATED PROTEIN KINASE ACTIVITY IN INTERLEUKIN-2 SIGNALING. The Journal of Biological Chemistry. 2003
  118. Anaplastic Lymphoma Kinase Is Required for Neurogenesis in the Developing Central Nervous System of Zebrafish. PLoS ONE. 2013
  119. Angiogenic Oligosaccharides of Hyaluronan Induce Multiple Signaling Pathways Affecting Vascular Endothelial Cell Mitogenic and Wound Healing Responses. The Journal of Biological Chemistry. 2002
  120. Angiopoietin-Like 4 Confers Resistance to Hypoxia/Serum Deprivation-Induced Apoptosis through PI3K/Akt and ERK1/2 Signaling Pathways in Mesenchymal Stem Cells. PLoS ONE. 2014
  121. Angiotensin II Reduces Cardiac AdipoR1 Expression through AT1 Receptor/ROS/ERK1/2/c-Myc Pathway. PLoS ONE. 2013
  122. Anti-Cancer Activity of an Osthole Derivative, NBM-T-BMX-OS01: Targeting Vascular Endothelial Growth Factor Receptor Signaling and Angiogenesis. PLoS ONE. 2013
  123. Antimicrobial and Anti-Inflammatory Activities of Endophytic Fungi Talaromyces wortmannii Extracts against Acne-Inducing Bacteria. PLoS ONE. 2014
  124. Anti-Neuroinflammatory Effects of the Calcium Channel Blocker Nicardipine on Microglial Cells: Implications for Neuroprotection. PLoS ONE. 2014
  125. Antitumor Effect of the Tyrosine Kinase Inhibitor Nilotinib on Gastrointestinal Stromal Tumor (GIST) and Imatinib-Resistant GIST Cells. PLoS ONE. 2014
  126. Apelin Increases Cardiac Contractility via Protein Kinase Cε- and Extracellular Signal-Regulated Kinase-Dependent Mechanisms. PLoS ONE. 2014
  127. Apigenin Induces the Apoptosis and Regulates MAPK Signaling Pathways in Mouse Macrophage ANA-1 Cells. PLoS ONE. 2014
  128. Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways. The FASEB Journal. 2005
  129. Apoptosis Suppression by Raf-1 and MEK1 Requires MEK- and Phosphatidylinositol 3-Kinase-Dependent Signals. Molecular and Cellular Biology. 2001
  130. Apparently Normal Tumor Necrosis Factor Receptor 1 Signaling in the Absence of the Silencer of Death Domains. Molecular and Cellular Biology. 2003
  131. Approaches to Define Antigen Receptor-induced Serine Kinase Signal Transduction Pathways. The Journal of Biological Chemistry. 2003
  132. Arrestin Regulates MAPK Activation and Prevents NADPH Oxidase-dependent Death of Cells Expressing CXCR2. The Journal of Biological Chemistry. 2004
  133. AT1 Receptor Mutant Lacking Heterotrimeric G Protein Coupling Activates the Src-Ras-ERK Pathway without Nuclear Translocation of ERKs. The Journal of Biological Chemistry. 2002
  134. Aurintricarboxylic Acid Blocks in Vitro and in Vivo Activity of YopH, an Essential Virulent Factor of Yersinia pestis, the Agent of Plague. The Journal of Biological Chemistry. 2003
  135. Autoimmunity-Associated LYP-W620 Does Not Impair Thymic Negative Selection of Autoreactive T Cells. PLoS ONE. 2014
  136. Autonomous Stimulation of Cancer Cell Plasticity by the Human NKG2D Lymphocyte Receptor Coexpressed with Its Ligands on Cancer Cells. PLoS ONE. 2014
  137. B-Cell Receptor- and Phorbol Ester-Induced NF-%CE%BAB and c-Jun N-Terminal Kinase Activation in B Cells Requires Novel Protein Kinase C’s. Molecular and Cellular Biology. 2001
  138. bcl-2 Induction of Urokinase Plasminogen Activator Receptor Expression in Human Cancer Cells through Sp1 Activation:INVOLVEMENT OF ERK1/ERK2 ACTIVITY. The Journal of Biological Chemistry. 2004
  139. BCRP/ABCG2 Inhibition Sensitizes Hepatocellular Carcinoma Cells to Sorafenib. PLoS ONE. 2013
  140. Bidirectional Functions of Arsenic as a Carcinogen and an Anti-Cancer Agent in Human Squamous Cell Carcinoma. PLoS ONE. 2014
  141. BikDDA, a Mutant of Bik with Longer Half-Life Expression Protein, Can Be a Novel Therapeutic Gene for Triple-Negative Breast Cancer. PLoS ONE. 2014
  142. Bile Acid Regulation of C/EBP%CE%B2, CREB, and c-Jun Function, via the Extracellular Signal-Regulated Kinase and c-Jun NH2-Terminal Kinase Pathways, Modulates the Apoptotic Response of Hepatocytes. Molecular and Cellular Biology. 2003
  143. Bim Is an Apoptosis Sensor That Responds to Loss of Survival Signals Delivered by Epidermal Growth Factor but Not Those Provided by Integrins. The Journal of Biological Chemistry. 2004
  144. Bisindolylmaleimide VIII Enhances DR5-mediated Apoptosis through the MKK4/JNK/p38 Kinase and the Mitochondrial Pathways. The Journal of Biological Chemistry. 2002
  145. Blood Lipid Mediator Sphingosine 1-Phosphate Potently Stimulates Platelet-derived Growth Factor-A and -B Chain Expression through S1P1-Gi-Ras-MAPK-dependent Induction of Kr%C3%BCppel-like Factor 5. The Journal of Biological Chemistry. 2004
  146. BMP4 Increases the Expression of TRPC and Basal [Ca2+]i via the p38MAPK and ERK1/2 Pathways Independent of BMPRII in PASMCs. PLoS ONE. 2014
  147. BMP9 Inhibits Proliferation and Metastasis of HER2-Positive SK-BR-3 Breast Cancer Cells through ERK1/2 and PI3K/AKT Pathways. PLoS ONE. 2014
  148. Bombesin and Substance P Analogues Differentially Regulate G-protein Coupling to the Bombesin Receptor:DIRECT EVIDENCE FOR BIASED AGONISM. The Journal of Biological Chemistry. 2001
  149. Bone Marrow-Derived Mesenchymal Stem Cells Drive Lymphangiogenesis. PLoS ONE. 2014
  150. Bone Morphogenetic Protein-2 Inhibits Serum Deprivation-induced Apoptosis of Neonatal Cardiac Myocytes through Activation of the Smad1 Pathway. The Journal of Biological Chemistry. 2001
  151. Bone Morphogenetic Protein-7 Signals Opposing Transforming Growth Factor %CE%B2 in Mesangial Cells. The Journal of Biological Chemistry. 2004
  152. Borna Disease Virus Persistent Infection Activates Mitogen-activated Protein Kinase and Blocks Neuronal Differentiation of PC12 Cells. The Journal of Biological Chemistry. 2001
  153. Brain-Derived Neurotrophic Factor Induces Matrix Metalloproteinase 9 Expression in Neurons via the Serum Response Factor/c-Fos Pathway. Molecular and Cellular Biology. 2013
  154. Building Bridges toward Invasion: Tumor Promoter Treatment Induces a Novel Protein Kinase C-Dependent Phenotype in MCF10A Mammary Cell Acini. PLoS ONE. 2014
  155. Ca2+-dependent Dephosphorylation of Kinesin Heavy Chain on %CE%B2-Granules in Pancreatic %CE%B2-Cells:IMPLICATIONS FOR REGULATED %CE%B2-GRANULE TRANSPORT AND INSULIN EXOCYTOSIS. The Journal of Biological Chemistry. 2002
  156. Caffeine Inhibits the Activation of Hepatic Stellate Cells Induced by Acetaldehyde via Adenosine A2A Receptor Mediated by the cAMP/PKA/SRC/ERK1/2/P38 MAPK Signal Pathway. PLoS ONE. 2014
  157. Caffeine Mediates Sustained Inactivation of Breast Cancer-Associated Myofibroblasts via Up-Regulation of Tumor Suppressor Genes. PLoS ONE. 2014
  158. Calcineurin Enhances MAPK Phosphatase-1 Expression and p38 MAPK Inactivation in Cardiac Myocytes. The Journal of Biological Chemistry. 2001
  159. Calcium Activation of ERK Mediated by Calmodulin Kinase I. The Journal of Biological Chemistry. 2004
  160. Calcium Induces Cell Survival and Proliferation through the Activation of the MAPK Pathway in a Human Hormone-dependent Leukemia Cell Line, TF-1. The Journal of Biological Chemistry. 2003
  161. Calcium Restriction Allows cAMP Activation of the B-Raf/ERK Pathway, Switching Cells to a cAMP-dependent Growth-stimulated Phenotype. The Journal of Biological Chemistry. 2004
  162. Calcium-induced Matrix Metalloproteinase 9 Gene Expression Is Differentially Regulated by ERK1/2 and p38 MAPK in Oral Keratinocytes and Oral Squamous Cell Carcinoma. The Journal of Biological Chemistry. 2004
  163. Calcium-sensing Receptor-mediated ERK1/2 Activation Requires G%CE%B1i2 Coupling and Dynamin-independent Receptor Internalization. The Journal of Biological Chemistry. 2004
  164. Calmodulin Binds to K-Ras, but Not to H- or N-Ras, and Modulates Its Downstream Signaling. Molecular and Cellular Biology. 2001
  165. Cannabidiol, a Non-Psychoactive Cannabinoid Compound, Inhibits Proliferation and Invasion in U87-MG and T98G Glioma Cells through a Multitarget Effect. PLoS ONE. 2013
  166. Cardiovascular Risks Associated with Low Dose Ionizing Particle Radiation. PLoS ONE. 2014
  167. Caveolar and Lipid Raft Localization of the Growth Hormone Receptor and Its Signaling Elements:IMPACT ON GROWTH HORMONE SIGNALING. The Journal of Biological Chemistry. 2004
  168. Caveolin-1 Gene Disruption Promotes Mammary Tumorigenesis and Dramatically Enhances Lung Metastasis in Vivo:ROLE OF CAV-1 IN CELL INVASIVENESS AND MATRIX METALLOPROTEINASE (MMP-2/9) SECRETION. The Journal of Biological Chemistry. 2004
  169. Cbl-3-Deficient Mice Exhibit Normal Epithelial Development. Molecular and Cellular Biology. 2003
  170. c-Cbl Associates Directly with the C-terminal Tail of the Receptor for the Macrophage Colony-stimulating Factor, c-Fms, and Down-modulates This Receptor but Not the Viral Oncogene v-Fms. The Journal of Biological Chemistry. 2002
  171. c-Cbl-mediated Ubiquitinylation Is Required for Epidermal Growth Factor Receptor Exit from the Early Endosomes. The Journal of Biological Chemistry. 2004
  172. CCR6 Is a Prognostic Marker for Overall Survival in Patients with Colorectal Cancer, and Its Overexpression Enhances Metastasis In Vivo. PLoS ONE. 2014
  173. Cdc2-Cyclin B Triggers H3 Kinase Activation of Aurora-A in Xenopus Oocytes. The Journal of Biological Chemistry. 2003
  174. cDNA Cloning and Functional Expression of a Ca2+-sensing Receptor with Truncated C-terminal Tail from the Mozambique Tilapia (Oreochromis mossambicus). The Journal of Biological Chemistry. 2004
  175. Cell Condition-dependent Regulation of ERK5 by cAMP. The Journal of Biological Chemistry. 2002
  176. Cell Cycle-dependent Regulation of Pyrimidine Biosynthesis. The Journal of Biological Chemistry. 2003
  177. Cell Stress Induces Upregulation of Osteopontin via the ERK Pathway in Type II Alveolar Epithelial Cells. PLoS ONE. 2014
  178. Cellular N-Ras Promotes Cell Survival by Downregulation of Jun N-Terminal Protein Kinase and p38. Molecular and Cellular Biology. 2002
  179. Cellular Recognition of Tri-/Di-palmitoylated Peptides Is Independent from a Domain Encompassing the N-terminal Seven Leucine-rich Repeat (LRR)/LRR-like Motifs of TLR2. The Journal of Biological Chemistry. 2003
  180. Ceramide Mediates Age-associated Increase in Macrophage Cyclooxygenase-2 Expression. The Journal of Biological Chemistry. 2002
  181. cGMP-dependent Protein Kinase Inhibits Serum-response Element-dependent Transcription by Inhibiting Rho Activation and Functions. The Journal of Biological Chemistry. 2002
  182. Characterization of a Novel Negative Regulator (DOC-2/DAB2) of c-Src in Normal Prostatic Epithelium and Cancer. The Journal of Biological Chemistry. 2003
  183. Characterization of lpa2 (Edg4) and lpa1/lpa2 (Edg2/Edg4) Lysophosphatidic Acid Receptor Knockout Mice: Signaling Deficits without Obvious Phenotypic Abnormality Attributable to lpa2. Molecular and Cellular Biology. 2002
  184. Characterization of Sequence Determinants within the Carboxyl-terminal Domain of Chemokine Receptor CCR5 That Regulate Signaling and Receptor Internalization. The Journal of Biological Chemistry. 2001
  185. Characterization of the Signaling Capacities of the Novel gp130-like Cytokine Receptor. The Journal of Biological Chemistry. 2004
  186. Cholesterol Oxidase Is Indispensable in the Pathogenesis of Mycobacterium tuberculosis. PLoS ONE. 2013
  187. Chronic Ethanol Increases Lipopolysaccharide-stimulated Egr-1 Expression in RAW 264.7 Macrophages:CONTRIBUTION TO ENHANCED TUMOR NECROSIS FACTOR %CE%B1 PRODUCTION. The Journal of Biological Chemistry. 2002
  188. Chronic Exposure to Combined Carcinogens Enhances Breast Cell Carcinogenesis with Mesenchymal and Stem-Like Cell Properties. PLoS ONE. 2014
  189. c-Jun N-terminal Kinase Specifically Phosphorylates p66ShcA at Serine 36 in Response to Ultraviolet Irradiation. The Journal of Biological Chemistry. 2001
  190. c-Jun/Activator Protein-1 Mediates Interleukin-1%CE%B2-induced Dedifferentiation but Not Cyclooxygenase-2 Expression in Articular Chondrocytes. The Journal of Biological Chemistry. 2005
  191. Clathrin Assembly Protein CALM Plays a Critical Role in KIT Signaling by Regulating Its Cellular Transport from Early to Late Endosomes in Hematopoietic Cells. PLoS ONE. 2014
  192. Cloning and Biological Activity of Epigen, a Novel Member of the Epidermal Growth Factor Superfamily. The Journal of Biological Chemistry. 2001
  193. Cloning and Characterization of a Protein Kinase A Anchoring Protein (AKAP)-related Protein That Interacts with and Regulates Sphingosine Kinase 1 Activity. The Journal of Biological Chemistry. 2002
  194. Cloning and Characterization of ALX, an Adaptor Downstream of CD28. The Journal of Biological Chemistry. 2003
  195. Clostridium difficile Toxin A Regulates Inducible Cyclooxygenase-2 and Prostaglandin E2 Synthesis in Colonocytes via Reactive Oxygen Species and Activation of p38 MAPK. The Journal of Biological Chemistry. 2005
  196. Clostridium perfringens Phospholipase C Induced ROS Production and Cytotoxicity Require PKC, MEK1 and NFκB Activation. PLoS ONE. 2014
  197. c-myc Regulates Cell Proliferation during Lens Development. PLoS ONE. 2014
  198. CMZ Reversed Chronic Ethanol-Induced Disturbance of PPAR-α Possibly by Suppressing Oxidative Stress and PGC-1α Acetylation, and Activating the MAPK and GSK3β Pathway. PLoS ONE. 2014
  199. CNN3 Regulates Trophoblast Invasion and Is Upregulated by Hypoxia in BeWo Cells. PLoS ONE. 2014
  200. Collaboration of JNKs and ERKs in Nerve Growth Factor Regulation of the Neurofilament Light Chain Promoter in PC12 Cells. The Journal of Biological Chemistry. 2002
  201. Combined Loss of INK4a and Caveolin-1 Synergistically Enhances Cell Proliferation and Oncogene-induced Tumorigenesis:ROLE OF INK4a/CAV-1 IN MAMMARY EPITHELIAL CELL HYPERPLASIA. The Journal of Biological Chemistry. 2004
  202. Common Structural Basis for Constitutive Activity of the Ghrelin Receptor Family. The Journal of Biological Chemistry. 2004
  203. Comparative Analysis of TGF-β/Smad Signaling Dependent Cytostasis in Human Hepatocellular Carcinoma Cell Lines. PLoS ONE. 2013
  204. Comparative Study of Somatostatin-Human Serum Albumin Fusion Proteins and Natural Somatostatin on Receptor Binding, Internalization and Activation. PLoS ONE. 2014
  205. Conjugated Linoleic Acid Induces Human Adipocyte Delipidation:AUTOCRINE/PARACRINE REGULATION OF MEK/ERK SIGNALING BY ADIPOCYTOKINES. The Journal of Biological Chemistry. 2004
  206. Constitutive Activation of Extracellular Signal-regulated Kinase 2 by Synergistic Point Mutations. The Journal of Biological Chemistry. 2001
  207. Constitutive ERK1/2 Activation in Esophagogastric Rib Bone Marrow Micrometastatic Cells Is MEK-independent. The Journal of Biological Chemistry. 2001
  208. Constitutive Induction of p-Erk1/2 Accompanied by Reduced Activities of Protein Phosphatases 1 and 2A and MKP3 Due to Reactive Oxygen Species during Cellular Senescence. The Journal of Biological Chemistry. 2003
  209. Constitutive Localization of the Gonadotropin-releasing Hormone (GnRH) Receptor to Low Density Membrane Microdomains Is Necessary for GnRH Signaling to ERK. The Journal of Biological Chemistry. 2003
  210. Constitutive Phosphorylation of GATA-1 at Serine26 Attenuates the Colony-Forming Activity of Erythrocyte-Committed Progenitors. PLoS ONE. 2013
  211. Constitutive Protease-activated Receptor-2-mediated Migration of MDA MB-231 Breast Cancer Cells Requires Both %CE%B2-Arrestin-1 and -2. The Journal of Biological Chemistry. 2004
  212. Constitutive STAT3 Activation in Intestinal T Cells from Patients with Crohn’s Disease. The Journal of Biological Chemistry. 2003
  213. Constitutively Active Mutants of the %CE%B11a- and the %CE%B11b-Adrenergic Receptor Subtypes Reveal Coupling to Different Signaling Pathways and Physiological Responses in Rat Cardiac Myocytes. The Journal of Biological Chemistry. 2000
  214. Contribution of Macrophage Migration Inhibitory Factor to Extracellular Signal-regulated Kinase Activation by Oxidative Stress in Cardiomyocytes. The Journal of Biological Chemistry. 2002
  215. Cooperation of Protein Kinase A and Ras/ERK Signaling Pathways Is Required for AP-1-mediated Activation of Fibroblast Growth Factor-inducible Response Element (FiRE). The Journal of Biological Chemistry. 2002
  216. Cooperative Regulation of the Cell Division Cycle by the Protein Kinases RAF and AKT. Molecular and Cellular Biology. 2004
  217. Cooperativity between the Ras-ERK and Rho-Rho Kinase Pathways in Urokinase-type Plasminogen Activator-stimulated Cell Migration. The Journal of Biological Chemistry. 2002
  218. Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis. PLoS ONE. 2014
  219. Coordinated Activation of Autophosphorylation Sites in the RET Receptor Tyrosine Kinase:IMPORTANCE OF TYROSINE 1062 FOR GDNF MEDIATED NEURONAL DIFFERENTIATION AND SURVIVAL. The Journal of Biological Chemistry. 2002
  220. Co-requirement of Cyclic AMP- and Calcium-dependent Protein Kinases for Transcriptional Activation of Cholecystokinin Gene by Protein Hydrolysates. The Journal of Biological Chemistry. 2002
  221. COSMC Is Overexpressed in Proliferating Infantile Hemangioma and Enhances Endothelial Cell Growth via VEGFR2. PLoS ONE. 2013
  222. C-Phycocyanin Confers Protection against Oxalate-Mediated Oxidative Stress and Mitochondrial Dysfunctions in MDCK Cells. PLoS ONE. 2014
  223. c-Raf/MEK/ERK Pathway Controls Protein Kinase C-mediated p70S6K Activation in Adult Cardiac Muscle Cells. The Journal of Biological Chemistry. 2002
  224. Critical Role of Endogenous Akt/IAPs and MEK1/ERK Pathways in Counteracting Endoplasmic Reticulum Stress-induced Cell Death. The Journal of Biological Chemistry. 2004
  225. Cross-talk among gp130 Cytokines in Adipocytes. The Journal of Biological Chemistry. 2005
  226. Cross-talk between Cytosolic Phospholipase A2%CE%B1 (cPLA2%CE%B1) and Secretory Phospholipase A2 (sPLA2) in Hydrogen Peroxide-induced Arachidonic Acid Release in Murine Mesangial Cells:sPLA2 REGULATES cPLA2%CE%B1 ACTIVITY THAT IS RESPONSIBLE FOR ARACHIDONIC ACID RELEASE. The Journal of Biological Chemistry. 2003
  227. Crystal Structure of Pyridoxal Kinase in Complex with Roscovitine and Derivatives. The Journal of Biological Chemistry. 2005
  228. c-SRC Mediates Neurite Outgrowth through Recruitment of Crk to the Scaffolding Protein Sin/Efs without Altering the Kinetics of ERK Activation ,. The Journal of Biological Chemistry. 2002
  229. CXCR2-Driven Ovarian Cancer Progression Involves Upregulation of Proinflammatory Chemokines by Potentiating NF-κB Activation via EGFR-Transactivated Akt Signaling. PLoS ONE. 2013
  230. CYB5D2 Requires Heme-Binding to Regulate HeLa Cell Growth and Confer Survival from Chemotherapeutic Agents. PLoS ONE. 2014
  231. Cyclic AMP Activation of the Extracellular Signal-regulated Kinases 1 and 2:IMPLICATIONS FOR INTESTINAL CELL SURVIVAL THROUGH THE TRANSIENT INHIBITION OF APOPTOSIS. The Journal of Biological Chemistry. 2004
  232. Cyclic AMP Induces Transactivation of the Receptors for Epidermal Growth Factor and Nerve Growth Factor, Thereby Modulating Activation of MAP Kinase, Akt, and Neurite Outgrowth in PC12 Cells. The Journal of Biological Chemistry. 2002
  233. Cyclic AMP Inhibits Extracellular Signal-regulated Kinase and Phosphatidylinositol 3-Kinase/Akt Pathways by Inhibiting Rap1. The Journal of Biological Chemistry. 2001
  234. Cyclic AMP Modulates the Functional Plasticity of Immature Dendritic Cells by Inhibiting Src-like Kinases through Protein Kinase A-mediated Signaling. The Journal of Biological Chemistry. 2004
  235. Cyclic GMP-dependent Protein Kinase Regulates the Expression of Thioredoxin and Thioredoxin Peroxidase-1 during Hormesis in Response to Oxidative Stress-induced Apoptosis. The Journal of Biological Chemistry. 2003
  236. Cyclin-dependent Kinase 5 Phosphorylates Serine 31 of Tyrosine Hydroxylase and Regulates Its Stability. The Journal of Biological Chemistry. 2004
  237. Cyclopentenone Isoprostanes Inhibit the Inflammatory Response in Macrophages. The Journal of Biological Chemistry. 2005
  238. CYLD Negatively Regulates Nontypeable Haemophilus influenzae-Induced IL-8 Expression via Phosphatase MKP-1-Dependent Inhibition of ERK. PLoS ONE. 2014
  239. Cystic Fibrosis Pathogens Activate Ca2+-dependent Mitogen-activated Protein Kinase Signaling Pathways in Airway Epithelial Cells. The Journal of Biological Chemistry. 2001
  240. Cytosolic Retention of Phosphorylated Extracellular Signal-Regulated Kinase and a Rho-Associated Kinase-Mediated Signal Impair Expression of p21Cip1/Waf1 in Phorbol 12-Myristate-13- Acetate-Induced Apoptotic Cells. Molecular and Cellular Biology. 2002
  241. D1 Dopamine Receptor Mediates Dopamine-induced Cytotoxicity via the ERK Signal Cascade. The Journal of Biological Chemistry. 2004
  242. DDX3X Induces Primary EGFR-TKI Resistance Based on Intratumor Heterogeneity in Lung Cancer Cells Harboring EGFR-Activating Mutations. PLoS ONE. 2014
  243. Decorin-mediated Signal Transduction in Endothelial Cells:INVOLVEMENT OF Akt/PROTEIN KINASE B IN UP-REGULATION OF p21WAF1/CIP1 BUT NOT p27KIP1%0A%0A. The Journal of Biological Chemistry. 2001
  244. Deep Sea Water Prevents Balloon Angioplasty-Induced Hyperplasia through MMP-2: An In Vitro and In Vivo Study. PLoS ONE. 2014
  245. Deletion of Mouse Embryo Fibroblast N-Acetylglucosaminyltransferase V Stimulates %CE%B15%CE%B21 Integrin Expression Mediated by the Protein Kinase C Signaling Pathway. The Journal of Biological Chemistry. 2005
  246. Deletion of the PDGFR-%CE%B2 Gene Affects Key Fibroblast Functions Important for Wound Healing. The Journal of Biological Chemistry. 2005
  247. Delphinidin Reduces Cell Proliferation and Induces Apoptosis of Non-Small-Cell Lung Cancer Cells by Targeting EGFR/VEGFR2 Signaling Pathways. PLoS ONE. 2013
  248. Demonstration of Direct Effects of Growth Hormone on Neonatal Cardiomyocytes. The Journal of Biological Chemistry. 2001
  249. Dephosphorylation of Endothelial Nitric-oxide Synthase by Vascular Endothelial Growth Factor:IMPLICATIONS FOR THE VASCULAR RESPONSES TO CYCLOSPORIN A. The Journal of Biological Chemistry. 2002
  250. Depolarization Activates ERK and Proline-rich Tyrosine Kinase 2 (PYK2) Independently in Different Cellular Compartments in Hippocampal Slices. The Journal of Biological Chemistry. 2005
  251. Depolarization of Skeletal Muscle Cells induces Phosphorylation of cAMP Response Element Binding Protein via Calcium and Protein Kinase C%CE%B1. The Journal of Biological Chemistry. 2004
  252. Development of an Epidermal Growth Factor Derivative with EGFR Blocking Activity. PLoS ONE. 2013
  253. Development of Pure Prolactin Receptor Antagonists. The Journal of Biological Chemistry. 2003
  254. Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB. The EMBO Journal. 2004
  255. Diallyl Disulfide Suppresses SRC/Ras/ERK Signaling-Mediated Proliferation and Metastasis in Human Breast Cancer by Up-Regulating miR-34a. PLoS ONE. 2014
  256. Differential Activation of Protein Kinase B and p70S6K by Glucose and Insulin-like Growth Factor 1 in Pancreatic %CE%B2-Cells (INS-1). The Journal of Biological Chemistry. 2001
  257. Differential and Conditional Activation of PKC-Isoforms Dictates Cardiac Adaptation during Physiological to Pathological Hypertrophy. PLoS ONE. 2014
  258. Differential Association of CD45 Isoforms with CD4 and CD8 Regulates the Actions of Specific Pools of p56lck Tyrosine Kinase in T Cell Antigen Receptor Signal Transduction. The Journal of Biological Chemistry. 2002
  259. Differential Desensitization, Receptor Phosphorylation, %CE%B2-Arrestin Recruitment, and ERK1/2 Activation by the Two Endogenous Ligands for the CC Chemokine Receptor 7. The Journal of Biological Chemistry. 2004
  260. Differential Effects of Nitrostyrene Derivatives on Myelopoiesis Involve Regulation of C/EBPα and p38MAPK Activity. PLoS ONE. 2014
  261. Differential Involvement of the Ras and Rap1 Small GTPases in Vasoactive Intestinal and Pituitary Adenylyl Cyclase Activating Polypeptides Control of the Prolactin Gene. The Journal of Biological Chemistry. 2003
  262. Differential Kinetic and Spatial Patterns of %CE%B2-Arrestin and G Protein-mediated ERK Activation by the Angiotensin II Receptor. The Journal of Biological Chemistry. 2004
  263. Differential Phosphorylation of c-Jun and JunD in Response to the Epidermal Growth Factor Is Determined by the Structure of MAPK Targeting Sequences. The Journal of Biological Chemistry. 2004
  264. Differential Regulation of Membrane Type 1-Matrix Metalloproteinase Activity by ERK 1/2- and p38 MAPK-modulated Tissue Inhibitor of Metalloproteinases 2 Expression Controls Transforming Growth Factor-%CE%B21-induced Pericellular Collagenolysis. The Journal of Biological Chemistry. 2004
  265. Differential Regulation of the B Cell Receptor-mediated Signaling by the E3 Ubiquitin Ligase Cbl. The Journal of Biological Chemistry. 2004
  266. Differential Regulation of Tumor Angiogenesis by Distinct ErbB Homo- and Heterodimers. Molecular Biology of the Cell. 2002
  267. Differential Responses to Nerve Growth Factor and Epidermal Growth Factor in Neurite Outgrowth of PC12 Cells Are Determined by Rac1 Activation Systems. The Journal of Biological Chemistry. 2001
  268. Differentiation Status-dependent Regulation of Cyclooxygenase-2 Expression and Prostaglandin E2 Production by Epidermal Growth Factor via Mitogen-activated Protein Kinase in Articular Chondrocytes. The Journal of Biological Chemistry. 2003
  269. Direct Interaction of the Novel Nox Proteins with p22phox Is Required for the Formation of a Functionally Active NADPH Oxidase. The Journal of Biological Chemistry. 2004
  270. Disabled-2 Exerts Its Tumor Suppressor Activity by Uncoupling c-Fos Expression and MAP Kinase Activation. The Journal of Biological Chemistry. 2001
  271. Disabled-2 Mediates c-Fos Suppression and the Cell Growth Regulatory Activity of Retinoic Acid in Embryonic Carcinoma Cells. The Journal of Biological Chemistry. 2001
  272. Disassociation of MAPK Activation and c-Fos Expression in F9 Embryonic Carcinoma Cells following Retinoic Acid-induced Endoderm Differentiation. The Journal of Biological Chemistry. 2001
  273. Discovery of Novel AKT Inhibitors with Enhanced Anti-Tumor Effects in Combination with the MEK Inhibitor. PLoS ONE. 2014
  274. Distinct Cell Cycle Timing Requirements for Extracellular Signal-Regulated Kinase and Phosphoinositide 3-Kinase Signaling Pathways in Somatic Cell Mitosis. Molecular and Cellular Biology. 2002
  275. Distinct Mechanisms Determine the Patterns of Differential Activation of H-Ras, N-Ras, K-Ras 4B, and M-Ras by Receptors for Growth Factors or Antigen. Molecular and Cellular Biology. 2004
  276. Distinct Pathways for the Trafficking of Angiotensin II and Adrenergic Receptors from the Endoplasmic Reticulum to the Cell Surface:Rab1-INDEPENDENT TRANSPORT OF A G PROTEIN-COUPLED RECEPTOR. The Journal of Biological Chemistry. 2003
  277. Distinct Pathways of ERK1/2 Activation by Hydroxy-Carboxylic Acid Receptor-1. PLoS ONE. 2014
  278. Distinct Roles of the I%CE%BAB Kinase %CE%B1 and %CE%B2 Subunits in Liberating Nuclear Factor %CE%BAB (NF-%CE%BAB) from I%CE%BAB and in Phosphorylating the p65 Subunit of NF-%CE%BAB. The Journal of Biological Chemistry. 2002
  279. Disturbing miR-182 and -381 Inhibits BRD7 Transcription and Glioma Growth by Directly Targeting LRRC4. PLoS ONE. 2014
  280. Down-regulation by Antisense Oligonucleotides Establishes a Role for the Proline-rich Tyrosine Kinase PYK2 in Angiotensin II-induced Signaling in Vascular Smooth Muscle. The Journal of Biological Chemistry. 2001
  281. Down-regulation of Cholesterol 7%CE%B1-Hydroxylase (CYP7A1) Gene Expression by Bile Acids in Primary Rat Hepatocytes Is Mediated by the c-Jun N-terminal Kinase Pathway. The Journal of Biological Chemistry. 2001
  282. Downregulation of PAX6 by shRNA Inhibits Proliferation and Cell Cycle Progression of Human Non-Small Cell Lung Cancer Cell Lines. PLoS ONE. 2014
  283. Downregulation of Ras Association Domain Family Member 6 (RASSF6) Underlies the Treatment Resistance of Highly Metastatic Nasopharyngeal Carcinoma Cells. PLoS ONE. 2014
  284. Downregulation of the Ras%E2%80%93Mitogen-Activated Protein Kinase Pathway by the EphB2 Receptor Tyrosine Kinase Is Required for Ephrin-Induced Neurite Retraction. Molecular and Cellular Biology. 2001
  285. Dual Inhibition of Focal Adhesion Kinase and Epidermal Growth Factor Receptor Pathways Cooperatively Induces Death Receptor-mediated Apoptosis in Human Breast Cancer Cells. The Journal of Biological Chemistry. 2002
  286. Dual Regulation of MMP-2 Expression by the Type 1 Insulin-like Growth Factor Receptor:THE PHOSPHATIDYLINOSITOL 3-KINASE/Akt AND Raf/ERK PATHWAYS TRANSMIT OPPOSING SIGNALS. The Journal of Biological Chemistry. 2004
  287. Dual Regulation of Phosphorylation and Dephosphorylation of C/EBP%CE%B2 Modulate Its Transcriptional Activation and DNA Binding in Response to Growth Hormone. The Journal of Biological Chemistry. 2002
  288. Dynamic Regulation of Extracellular Signal-Regulated Kinase (ERK) by Protein Phosphatase 2A Regulatory Subunit B56γ1 in Nuclei Induces Cell Migration. PLoS ONE. 2013
  289. Dynamic Regulation of the Translation Initiation Helicase Complex by Mitogenic Signal Transduction to Eukaryotic Translation Initiation Factor 4G. Molecular and Cellular Biology. 2013
  290. Dynamin and Rab5a-dependent Trafficking and Signaling of the Neurokinin 1 Receptor. The Journal of Biological Chemistry. 2001
  291. Early Activation of MAP Kinases by Influenza A Virus X-31 in Murine Macrophage Cell Lines. PLoS ONE. 2014
  292. Ectopic B-Raf Expression Enhances Extracellular Signal-regulated Kinase (ERK) Signaling in T Cells and Prevents Antigen-presenting Cell-induced Anergy. The Journal of Biological Chemistry. 2003
  293. Ectopic Expression of Homeobox Gene NKX2-1 in Diffuse Large B-Cell Lymphoma Is Mediated by Aberrant Chromatin Modifications. PLoS ONE. 2013
  294. Edaravone Protect against Retinal Damage in Streptozotocin-Induced Diabetic Mice. PLoS ONE. 2014
  295. Effect of Extracellular Signal-regulated Kinase on p53 Accumulation in Response to Cisplatin. The Journal of Biological Chemistry. 2000
  296. Effective Therapeutic Approach for Head and Neck Cancer by an Engineered Minibody Targeting the EGFR Receptor. PLoS ONE. 2014
  297. Efficient Transient Transfection of Human Multiple Myeloma Cells by Electroporation – An Appraisal. PLoS ONE. 2014
  298. Eicosanoid Regulation of Vascular Endothelial Growth Factor Expression and Angiogenesis in Microvessel Endothelial Cells. The Journal of Biological Chemistry. 2002
  299. Elastase-released Epidermal Growth Factor Recruits Epidermal Growth Factor Receptor and Extracellular Signal-regulated Kinases to Down-regulate Tropoelastin mRNA in Lung Fibroblasts. The Journal of Biological Chemistry. 2002
  300. Elevated Akt Phosphorylation as an Indicator of Renal Tubular Epithelial Cell Stress. The Journal of Biological Chemistry. 2002
  301. Endocytosed HSP60s Use Toll-like Receptor 2 (TLR2) and TLR4 to Activate the Toll/Interleukin-1 Receptor Signaling Pathway in Innate Immune Cells. The Journal of Biological Chemistry. 2001
  302. Endocytosis of Mycobacterium tuberculosis Heat Shock Protein 60 Is Required to Induce Interleukin-10 Production in Macrophages. The Journal of Biological Chemistry. 2013
  303. Endogenous RGS Protein Action Modulates %CE%BC-Opioid Signaling through G%CE%B1o:EFFECTS ON ADENYLYL CYCLASE, EXTRACELLULAR SIGNAL-REGULATED KINASES, AND INTRACELLULAR CALCIUM PATHWAYS. The Journal of Biological Chemistry. 2003
  304. Endogenous TGF-[beta] signaling suppresses maturation of osteoblastic mesenchymal cells. The EMBO Journal. 2004
  305. Endothelin-1 Promotes Survival and Chemoresistance in Chronic Lymphocytic Leukemia B Cells through ETA Receptor. PLoS ONE. 2014
  306. Enhanced Activation of Mitogen-activated Protein Kinase and Myosin Light Chain Kinase by the Pro33 Polymorphism of Integrin %CE%B23. The Journal of Biological Chemistry. 2003
  307. Enhanced Insulin Sensitivity Associated with Provision of Mono and Polyunsaturated Fatty Acids in Skeletal Muscle Cells Involves Counter Modulation of PP2A. PLoS ONE. 2014
  308. Enhancement of Serum- and Platelet-derived Growth Factor-induced Cell Proliferation by Necl-5/Tage4/Poliovirus Receptor/CD155 through the Ras-Raf-MEK-ERK Signaling. The Journal of Biological Chemistry. 2004
  309. Enhancement of Tyrosine Hydroxylase Phosphorylation and Activity by Glial Cell Line-derived Neurotrophic Factor. The Journal of Biological Chemistry. 2004
  310. Epac Activation Converts cAMP from a Proliferative into a Differentiation Signal in PC12 Cells. Molecular Biology of the Cell. 2005
  311. EphB1-mediated Cell Migration Requires the Phosphorylation of Paxillin at Tyr-31/Tyr-118. The Journal of Biological Chemistry. 2004
  312. Epidermal and Hepatocyte Growth Factors, but Not Keratinocyte Growth Factor, Modulate Protein Kinase C%CE%B1 Translocation to the Plasma Membrane through 15(S)-Hydroxyeicosatetraenoic Acid Synthesis. The Journal of Biological Chemistry. 2005
  313. Epidermal Growth Factor (EGF) Receptor-dependent ERK Activation by G Protein-coupled Receptors:A CO-CULTURE SYSTEM FOR IDENTIFYING INTERMEDIATES UPSTREAM AND DOWNSTREAM OF HEPARIN-BINDING EGF SHEDDING. The Journal of Biological Chemistry. 2001
  314. Epidermal Growth Factor Receptor Transactivation Mediates Tumor Necrosis Factor-induced Hepatocyte Replication. The Journal of Biological Chemistry. 2004
  315. Epidermal Growth Factor Receptor-dependent and -independent Cell-signaling Pathways Originating from the Urokinase Receptor. The Journal of Biological Chemistry. 2003
  316. Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF. The EMBO Journal. 2001
  317. Epidermal Growth Factor-Induced Tumor Cell Invasion and Metastasis Initiated by Dephosphorylation and Downregulation of Focal Adhesion Kinase. Molecular and Cellular Biology. 2001
  318. Epidermal Growth Factor-mediated Activation of the ETS Domain Transcription Factor Elk-1 Requires Nuclear Calcium. The Journal of Biological Chemistry. 2002
  319. Epidermal Growth Factor-mediated T-cell Factor/Lymphoid Enhancer Factor Transcriptional Activity Is Essential but Not Sufficient for Cell Cycle Progression in Nontransformed Mammary Epithelial Cells. The Journal of Biological Chemistry. 2004
  320. Epigallocatechin-3-gallate Inhibits Epidermal Growth Factor Receptor Signaling Pathway:EVIDENCE FOR DIRECT INHIBITION OF ERK1/2 AND AKT KINASES. The Journal of Biological Chemistry. 2004
  321. ERK MAP Kinase Activation in Spinal Cord Regulates Phosphorylation of Cdk5 at Serine 159 and Contributes to Peripheral Inflammation Induced Pain/Hypersensitivity. PLoS ONE. 2014
  322. ERK1 and ERK2 Activate CCAAAT/Enhancer-binding Protein-%CE%B2-dependent Gene Transcription in Response to Interferon-%CE%B3. The Journal of Biological Chemistry. 2001
  323. ERK1 Associates with %CE%B1v%CE%B23 Integrin and Regulates Cell Spreading on Vitronectin. The Journal of Biological Chemistry. 2003
  324. ERK1/2 Achieves Sustained Activation by Stimulating MAPK Phosphatase-1 Degradation via the Ubiquitin-Proteasome Pathway. The Journal of Biological Chemistry. 2003
  325. ERK1/2 Antagonizes Glycogen Synthase Kinase-3%CE%B2-induced Apoptosis in Cortical Neurons. The Journal of Biological Chemistry. 2002
  326. ERK1/2 Associates with the c-Met-binding Domain of Growth Factor Receptor-bound Protein 2 (Grb2)-associated Binder-1 (Gab1):ROLE IN ERK1/2 AND EARLY GROWTH RESPONSE FACTOR-1 (Egr-1) NUCLEAR ACCUMULATION. The Journal of Biological Chemistry. 2004
  327. ERK1/2 Controls Na,K-ATPase Activity and Transepithelial Sodium Transport in the Principal Cell of the Cortical Collecting Duct of the Mouse Kidney. The Journal of Biological Chemistry. 2004
  328. ERK1/2 Mediates Insulin Stimulation of Na,K-ATPase by Phosphorylation of the %CE%B1-Subunit in Human Skeletal Muscle Cells. The Journal of Biological Chemistry. 2004
  329. ERK1/2 Pathway-Mediated Differentiation of IGF-1-Transfected Spinal Cord-Derived Neural Stem Cells into Oligodendrocytes. PLoS ONE. 2014
  330. ERK1/2 Regulates Intracellular ATP Levels through %CE%B1-Enolase Expression in Cardiomyocytes Exposed to Ischemic Hypoxia and Reoxygenation. The Journal of Biological Chemistry. 2004
  331. ERK2 Suppresses Self-Renewal Capacity of Embryonic Stem Cells, but Is Not Required for Multi-Lineage Commitment. PLoS ONE. 2013
  332. Erk5 Participates in Neuregulin Signal Transduction and Is Constitutively Active in Breast Cancer Cells Overexpressing ErbB2. Molecular and Cellular Biology. 2002
  333. Estrogen Receptor-mediated Activation of the Serum Response Element in MCF-7 Cells through MAPK-dependent Phosphorylation of Elk-1. The Journal of Biological Chemistry. 2001
  334. Estrogen-Dependent Proteolytic Cleavage of Semaphorin 4D and Plexin-B1 Enhances Semaphorin 4D-Induced Apoptosis during Postnatal Vaginal Remodeling in Pubescent Mice. PLoS ONE. 2014
  335. Estrogen-induced Smooth Muscle Cell Growth Is Regulated by Tuberin and Associated with Altered Activation of Platelet-derived Growth Factor Receptor-%CE%B2 and ERK-1/2. The Journal of Biological Chemistry. 2004
  336. Ethanol Impairs Intestinal Barrier Function in Humans through Mitogen Activated Protein Kinase Signaling: A Combined In Vivo and In Vitro Approach. PLoS ONE. 2014
  337. Evidence That Phosphatidylinositol 3-Kinase- and Mitogen-activated Protein Kinase Kinase-4/c-Jun NH2-terminal Kinase-dependent Pathways Cooperate to Maintain Lung Cancer Cell Survival. The Journal of Biological Chemistry. 2003
  338. Evidence That Tyrphostins AG10 and AG18 Are Mitochondrial Uncouplers That Alter Phosphorylation-dependent Cell Signaling. The Journal of Biological Chemistry. 2004
  339. Evodiamine Synergizes with Doxorubicin in the Treatment of Chemoresistant Human Breast Cancer without Inhibiting P-Glycoprotein. PLoS ONE. 2014
  340. Expression of Mutant %CE%B11 Na/K-ATPase Defective in Conformational Transition Attenuates Src-mediated Signal Transduction. The Journal of Biological Chemistry. 2013
  341. Expression of the High Molecular Weight Fibroblast Growth Factor-2 Isoform of 210 Amino Acids Is Associated with Modulation of Protein Kinases C %CE%B4 and %CE%B5 and ERK Activation. The Journal of Biological Chemistry. 2001
  342. Extracellular ATP-induced Proliferation of Adventitial Fibroblasts Requires Phosphoinositide 3-Kinase, Akt, Mammalian Target of Rapamycin, and p70 S6 Kinase Signaling Pathways. The Journal of Biological Chemistry. 2005
  343. Extracellular Heat Shock Protein 90 Signals through Subdomain II and the NPVY Motif of LRP-1 Receptor to Akt1 and Akt2: a Circuit Essential for Promoting Skin Cell Migration In Vitro and Wound Healing In Vivo. Molecular and Cellular Biology. 2013
  344. Extracellular Regulated Kinase/Mitogen Activated Protein Kinase Is Up-regulated in Pulmonary Emphysema and Mediates Matrix Metalloproteinase-1 Induction by Cigarette Smoke. The Journal of Biological Chemistry. 2004
  345. Extracellular S100A1 Protein Inhibits Apoptosis in Ventricular Cardiomyocytes via Activation of the Extracellular Signal-regulated Protein Kinase 1/2 (ERK1/2). The Journal of Biological Chemistry. 2003
  346. Extracellular Signal-regulated Kinase (ERK) Phosphorylates Histone Deacetylase 6 (HDAC6) at Serine 1035 to Stimulate Cell Migration. The Journal of Biological Chemistry. 2013
  347. Extracellular Signal-Regulated Kinase 1/2 Signaling Pathway Is Required for Endometrial Decidualization in Mice and Human. PLoS ONE. 2013
  348. Extracellular Signal-Regulated Kinase 2 Interacts with and Is Negatively Regulated by the LIM-Only Protein FHL2 in Cardiomyocytes. Molecular and Cellular Biology. 2004
  349. Extracellular Signal-regulated Kinase Activated by Epidermal Growth Factor and Cell Adhesion Interacts with and Phosphorylates Vinexin. The Journal of Biological Chemistry. 2004
  350. Extracellular Signal-regulated Kinase and Glycogen Synthase Kinase 3%CE%B2 Regulate Gephyrin Postsynaptic Aggregation and GABAergic Synaptic Function in a Calpain-dependent Mechanism. The Journal of Biological Chemistry. 2013
  351. Extracellular Signal-Regulated Kinase Regulates RhoA Activation and Tumor Cell Plasticity by Inhibiting Guanine Exchange Factor H1 Activity. Molecular and Cellular Biology. 2013
  352. Extracellular Signal-regulated Kinases 1/2 Are Serum-stimulated %E2%80%9CBimEL Kinases%E2%80%9D That Bind to the BH3-only Protein BimEL Causing Its Phosphorylation and Turnover. The Journal of Biological Chemistry. 2004
  353. Extracellular Signal-Regulated Kinases Phosphorylate Mitogen-Activated Protein Kinase Phosphatase 3/DUSP6 at Serines 159 and 197, Two Sites Critical for Its Proteasomal Degradation. Molecular and Cellular Biology. 2005
  354. Extracellular Zinc Triggers ERK-dependent Activation of Na+/H+ Exchange in Colonocytes Mediated by the Zinc-sensing Receptor. The Journal of Biological Chemistry. 2004
  355. FABP4 Induces Vascular Smooth Muscle Cell Proliferation and Migration through a MAPK-Dependent Pathway. PLoS ONE. 2013
  356. Factor Xa Induces Mitogenesis of Vascular Smooth Muscle Cells via Autocrine Production of Epiregulin. The Journal of Biological Chemistry. 2003
  357. FGF-23 Regulates CYP27B1 Transcription in the Kidney and in Extra-Renal Tissues. PLoS ONE. 2013
  358. Fibroblast Growth Factor 9 Activates Akt and MAPK Pathways to Stimulate Steroidogenesis in Mouse Leydig Cells. PLoS ONE. 2014
  359. Fibroblast Growth Factor Receptors as Novel Therapeutic Targets in SNF5-Deleted Malignant Rhabdoid Tumors. PLoS ONE. 2013
  360. Fibroblast Growth Factor-2 Induces Translational Regulation of Bcl-XL and Bcl-2 via a MEK-dependent Pathway:CORRELATION WITH RESISTANCE TO ETOPOSIDE-INDUCED APOPTOSIS. The Journal of Biological Chemistry. 2002
  361. Fibroblast Quiescence in Floating or Released Collagen Matrices:CONTRIBUTION OF THE ERK SIGNALING PATHWAY AND ACTIN CYTOSKELETAL ORGANIZATION. The Journal of Biological Chemistry. 2001
  362. Fibronectin Protects Prostate Cancer Cells from Tumor Necrosis Factor-%CE%B1-induced Apoptosis via the AKT/Survivin Pathway. The Journal of Biological Chemistry. 2003
  363. Filamin B Regulates Chondrocyte Proliferation and Differentiation through Cdk1 Signaling. PLoS ONE. 2014
  364. Fisetin Inhibits Human Melanoma Cell Invasion through Promotion of Mesenchymal to Epithelial Transition and by Targeting MAPK and NFκB Signaling Pathways. PLoS ONE. 2014
  365. Fisetin Inhibits Migration and Invasion of Human Cervical Cancer Cells by Down-Regulating Urokinase Plasminogen Activator Expression through Suppressing the p38 MAPK-Dependent NF-κB Signaling Pathway. PLoS ONE. 2013
  366. Flavonoid Apigenin Inhibits Lipopolysaccharide-Induced Inflammatory Response through Multiple Mechanisms in Macrophages. PLoS ONE. 2014
  367. Flos Puerariae Extract Prevents Myocardial Apoptosis via Attenuation Oxidative Stress in Streptozotocin-Induced Diabetic Mice. PLoS ONE. 2014
  368. Focal Adhesion Kinase Signaling Regulates Cardiogenesis of Embryonic Stem Cells. The Journal of Biological Chemistry. 2005
  369. Functional Characterization of WNT7A Signaling in PC12 Cells:INTERACTION WITH A FZD5%C2%B7LRP6 RECEPTOR COMPLEX AND MODULATION BY DICKKOPF PROTEINS. The Journal of Biological Chemistry. 2003
  370. Gab1 Contributes to Cytoskeletal Reorganization and Chemotaxis in Response to Platelet-derived Growth Factor. The Journal of Biological Chemistry. 2004
  371. Gab2 Phosphorylation by RSK Inhibits Shp2 Recruitment and Cell Motility. Molecular and Cellular Biology. 2013
  372. Galectin-1 Augments Ras Activation and Diverts Ras Signals to Raf-1 at the Expense of Phosphoinositide 3-Kinase. The Journal of Biological Chemistry. 2002
  373. Galectin-9 Enhances Cytokine Secretion, but Suppresses Survival and Degranulation, in Human Mast Cell Line. PLoS ONE. 2014
  374. Galectin-9 Protein Is Up-regulated in Astrocytes by Tumor Necrosis Factor and Promotes Encephalitogenic T-cell Apoptosis. The Journal of Biological Chemistry. 2013
  375. Gangliosides Act as Co-receptors for Salmonella enteritidis FliC and Promote FliC Induction of Human %CE%B2-Defensin-2 Expression in Caco-2 Cells. The Journal of Biological Chemistry. 2004
  376. Gas6 Stimulates Angiogenesis of Human Retinal Endothelial Cells and of Zebrafish Embryos via ERK1/2 Signaling. PLoS ONE. 2014
  377. Gastrin Stimulates Cyclooxygenase-2 Expression in Intestinal Epithelial Cells through Multiple Signaling Pathways:EVIDENCE FOR INVOLVEMENT OF ERK5 KINASE AND TRANSACTIVATION OF THE EPIDERMAL GROWTH FACTOR RECEPTOR. The Journal of Biological Chemistry. 2002
  378. Gefitinib and Luteolin Cause Growth Arrest of Human Prostate Cancer PC-3 Cells via Inhibition of Cyclin G-Associated Kinase and Induction of miR-630. PLoS ONE. 2014
  379. Gene Expression Profiling Identifies Microphthalmia-Associated Transcription Factor (MITF) and Dickkopf-1 (DKK1) as Regulators of Microenvironment-Driven Alterations in Melanoma Phenotype. PLoS ONE. 2014
  380. Generation and Characterization of a JAK2V617F-Containing Erythroleukemia Cell Line. PLoS ONE. 2014
  381. Genetic Deletion of the Tumor Necrosis Factor Receptor p60 or p80 Sensitizes Macrophages to Lipopolysaccharide-induced Nuclear Factor-%CE%BAB, Mitogen-activated Protein Kinases, and Apoptosis. The Journal of Biological Chemistry. 2003
  382. Genetic Evidence That Protease-activated Receptors Mediate Factor Xa Signaling in Endothelial Cells. The Journal of Biological Chemistry. 2002
  383. Gi2 Signaling Enhances Proliferation of Neural Progenitor Cells in the Developing Brain. The Journal of Biological Chemistry. 2004
  384. Ginsenoside Rb3 Protects Cardiomyocytes against Ischemia-Reperfusion Injury via the Inhibition of JNK-Mediated NF-κB Pathway: A Mouse Cardiomyocyte Model. PLoS ONE. 2014
  385. GIPC Interacts with the %CE%B21-Adrenergic Receptor and Regulates %CE%B21-Adrenergic Receptor-mediated ERK Activation. The Journal of Biological Chemistry. 2003
  386. GIT1 Functions as a Scaffold for MEK1-Extracellular Signal-Regulated Kinase 1 and 2 Activation by Angiotensin II and Epidermal Growth Factor. Molecular and Cellular Biology. 2004
  387. Glabridin Mediate Caspases Activation and Induces Apoptosis through JNK1/2 and p38 MAPK Pathway in Human Promyelocytic Leukemia Cells. PLoS ONE. 2014
  388. Glial Cell Line-derived Neurotrophic Factor-stimulated Phosphatidylinositol 3-Kinase and Akt Activities Exert Opposing Effects on the ERK Pathway:IMPORTANCE FOR THE RESCUE OF NEUROECTODERMIC CELLS. The Journal of Biological Chemistry. 2001
  389. Glucagon Promotes cAMP-response Element-binding Protein Phosphorylation via Activation of ERK1/2 in MIN6 Cell Line and Isolated Islets of Langerhans. The Journal of Biological Chemistry. 2004
  390. Glucagon Represses Signaling through the Mammalian Target of Rapamycin in Rat Liver by Activating AMP-activated Protein Kinase. The Journal of Biological Chemistry. 2004
  391. Glucocorticoid-Induced Leucine Zipper Inhibits the Raf-Extracellular Signal-Regulated Kinase Pathway by Binding to Raf-1. Molecular and Cellular Biology. 2002
  392. Glucose Utilization Is Essential for Hypoxia-Inducible Factor 1%CE%B1-Dependent Phosphorylation of c-Jun. Molecular and Cellular Biology. 2004
  393. Glucose-dependent Insulinotropic Polypeptide Activates the Raf-Mek1/2-ERK1/2 Module via a Cyclic AMP/cAMP-dependent Protein Kinase/Rap1-mediated Pathway. The Journal of Biological Chemistry. 2002
  394. Glycogen Synthase Kinase 3%CE%B2-Mediated Apoptosis of Primary Cortical Astrocytes Involves Inhibition of Nuclear Factor %CE%BAB Signaling. Molecular and Cellular Biology. 2003
  395. Glycogen Synthase Kinase-3%CE%B2 Regulates Growth, Calcium Homeostasis, and Diastolic Function in the Heart. The Journal of Biological Chemistry. 2004
  396. Granulocyte Macrophage Colony-stimulating Factor Signaling and Proteasome Inhibition Delay Neutrophil Apoptosis by Increasing the Stability of Mcl-1. The Journal of Biological Chemistry. 2004
  397. Granulocyte/Macrophage-Colony-stimulating Factor (GM-CSF) Regulates Lung Innate Immunity to Lipopolysaccharide through Akt/Erk Activation of NF%CE%BAB and AP-1 in Vivo. The Journal of Biological Chemistry. 2002
  398. Green Tea Phenolic Epicatechins Inhibit Hepatitis C Virus Replication via Cycloxygenase-2 and Attenuate Virus-Induced Inflammation. PLoS ONE. 2013
  399. Group I Metabotropic Glutamate Receptors Mediate a Dual Role of Glutamate in T Cell Activation. The Journal of Biological Chemistry. 2004
  400. Growth Hormone-induced Phosphorylation of Epidermal Growth Factor (EGF) Receptor in 3T3-F442A Cells:MODULATION OF EGF-INDUCED TRAFFICKING AND SIGNALING. The Journal of Biological Chemistry. 2003
  401. Growth-dependent Regulation of Mammalian Pyrimidine Biosynthesis by the Protein Kinase A and MAPK Signaling Cascades. The Journal of Biological Chemistry. 2002
  402. GTPases and Phosphatidylinositol 3-Kinase Are Critical for Insulin-like Growth Factor-I-mediated Schwann Cell Motility. The Journal of Biological Chemistry. 2000
  403. Head Involution Defective (Hid)-triggered Apoptosis Requires Caspase-8 but Not FADD (Fas-associated Death Domain) and Is Regulated by Erk in Mammalian Cells. The Journal of Biological Chemistry. 2002
  404. Heart and Liver Defects and Reduced Transforming Growth Factor %CE%B22 Sensitivity in Transforming Growth Factor %CE%B2 Type III Receptor-Deficient Embryos. Molecular and Cellular Biology. 2003
  405. Helicobacter pylori CagA Induces Ras-independent Morphogenetic Response through SHP-2 Recruitment and Activation. The Journal of Biological Chemistry. 2004
  406. Helicobacter pylori VacA Activates the p38/Activating Transcription Factor 2-mediated Signal Pathway in AZ-521 Cells. The Journal of Biological Chemistry. 2004
  407. Heparin/Heparan Sulfate Domains in Binding and Signaling of Fibroblast Growth Factor 8b. The Journal of Biological Chemistry. 2002
  408. Hepatocyte Growth Factor Inhibits Anoikis in Head and Neck Squamous Cell Carcinoma Cells by Activation of ERK and Akt Signaling Independent of NF%CE%BAB. The Journal of Biological Chemistry. 2002
  409. Hepatocyte Resistance to Oxidative Stress Is Dependent on Protein Kinase C-mediated Down-regulation of c-Jun/AP-1. The Journal of Biological Chemistry. 2004
  410. Hetero-oligomerization between %CE%B22- and %CE%B23-Adrenergic Receptors Generates a %CE%B2-Adrenergic Signaling Unit with Distinct Functional Properties. The Journal of Biological Chemistry. 2004
  411. High Intensity ras Signaling Induces Premature Senescence by Activating p38 Pathway in Primary Human Fibroblasts. The Journal of Biological Chemistry. 2004
  412. High-throughput Immunoblotting:UBIQUITIN-LIKE PROTEIN ISG15 MODIFIES KEY REGULATORS OF SIGNAL TRANSDUCTION. The Journal of Biological Chemistry. 2003
  413. HIV Nef Inhibits T Cell Migration. The Journal of Biological Chemistry. 2002
  414. HIV-1 Nef Promotes Survival of TF-1 Macrophages by Inducing Bcl-XL Expression in an Extracellular Signal-regulated Kinase-dependent Manner. The Journal of Biological Chemistry. 2004
  415. HIV-Associated Disruption of Tight and Adherens Junctions of Oral Epithelial Cells Facilitates HSV-1 Infection and Spread. PLoS ONE. 2014
  416. HMGB1 Protein Does Not Mediate the Inflammatory Response in Spontaneous Spinal Cord Regeneration:A HINT FOR CNS REGENERATION. The Journal of Biological Chemistry. 2013
  417. Hormonal Induction and Roles of Disabled-2 in Lactation and Involution. PLoS ONE. 2014
  418. H-Ras and Phosphoinositide 3-Kinase Cooperate to Induce %CE%B1(1,3)-Fucosyltransferase VII Expression in Jurkat T Cells. The Journal of Biological Chemistry. 2004
  419. H-Ras-specific Activation of Rac-MKK3/6-p38 Pathway:ITS CRITICAL ROLE IN INVASION AND MIGRATION OF BREAST EPITHELIAL CELLS. The Journal of Biological Chemistry. 2005
  420. Hsc/Hsp70 Interacting Protein (Hip) Associates with CXCR2 and Regulates the Receptor Signaling and Trafficking. The Journal of Biological Chemistry. 2002
  421. hSos1 Contains a New Amino-terminal Regulatory Motif with Specific Binding Affinity for Its Pleckstrin Homology Domain. The Journal of Biological Chemistry. 2002
  422. Human but Not Murine Toll-like Receptor 2 Discriminates between Tri-palmitoylated and Tri-lauroylated Peptides. The Journal of Biological Chemistry. 2004
  423. Human Group V Phospholipase A2 Induces Group IVA Phospholipase A2-independent Cysteinyl Leukotriene Synthesis in Human Eosinophils. The Journal of Biological Chemistry. 2003
  424. Human Homolog of Disc-large Is Required for Adherens Junction Assembly and Differentiation of Human Intestinal Epithelial Cells. The Journal of Biological Chemistry. 2004
  425. Hyaluronan-CD44 Interaction Promotes Growth of Decidual Stromal Cells in Human First-Trimester Pregnancy. PLoS ONE. 2013
  426. Hydrogen Peroxide Stimulates c-Src-mediated Big Mitogen-activated Protein Kinase 1 (BMK1) and the MEF2C Signaling Pathway in PC12 Cells:POTENTIAL ROLE IN CELL SURVIVAL FOLLOWING OXIDATIVE INSULTS. The Journal of Biological Chemistry. 2002
  427. Hyper-Activation of Notch3 Amplifies the Proliferative Potential of Rhabdomyosarcoma Cells. PLoS ONE. 2014
  428. Hyperthermia-Induced NDRG2 Upregulation Inhibits the Invasion of Human Hepatocellular Carcinoma via Suppressing ERK1/2 Signaling Pathway. PLoS ONE. 2013
  429. Hypoxia Antagonizes Glucose Deprivation on Interleukin 6 Expression in an Akt Dependent, but HIF-1/2α Independent Manner. PLoS ONE. 2013
  430. Hypoxia Promotes Epithelial – Mesenchymal Transition of Hepatocellular Carcinoma Cells via Inducing GLIPR-2 Expression. PLoS ONE. 2013
  431. Hypoxia Promotes Uveal Melanoma Invasion through Enhanced Notch and MAPK Activation. PLoS ONE. 2014
  432. Hypoxia-induced Proliferative Response of Vascular Adventitial Fibroblasts Is Dependent on G Protein-mediated Activation of Mitogen-activated Protein Kinases. The Journal of Biological Chemistry. 2001
  433. Identification of a C-terminal Region That Regulates Mitogen-activated Protein Kinase Kinase-1 Cytoplasmic Localization and ERK Activation. The Journal of Biological Chemistry. 2001
  434. Identification of a Dominant Negative Mutant of Sprouty That Potentiates Fibroblast Growth Factor- but Not Epidermal Growth Factor-induced ERK Activation. The Journal of Biological Chemistry. 2001
  435. Identification of a Network Involved in Thapsigargin-induced Apoptosis Using a Library of Small Interfering RNA Expression Vectors. The Journal of Biological Chemistry. 2005
  436. Identification of a Novel Extracellular Cation-sensing G-protein-coupled Receptor. The Journal of Biological Chemistry. 2005
  437. Identification of Benzimidazole Diamides as Selective Inhibitors of the Nucleotide-Binding Oligomerization Domain 2 (NOD2) Signaling Pathway. PLoS ONE. 2013
  438. Identification of Calcium-independent Phospholipase A2 (iPLA2) %CE%B2, and Not iPLA2%CE%B3, as the Mediator of Arginine Vasopressin-induced Arachidonic Acid Release in A-10 Smooth Muscle Cells:ENANTIOSELECTIVE MECHANISM-BASED DISCRIMINATION OF MAMMALIAN iPLA2s%0A. The Journal of Biological Chemistry. 2002
  439. Identification of Candida glabrata Genes Involved in pH Modulation and Modification of the Phagosomal Environment in Macrophages. PLoS ONE. 2014
  440. Identification of Canonical Tyrosine-dependent and Non-canonical Tyrosine-independent STAT3 Activation Sites in the Intracellular Domain of the Interleukin 23 Receptor. The Journal of Biological Chemistry. 2013
  441. Identification of KMU-3, a Novel Derivative of Gallic Acid, as an Inhibitor of Adipogenesis. PLoS ONE. 2014
  442. Identification of Pharmacological Modulators of HMGB1-Induced Inflammatory Response by Cell-Based Screening. PLoS ONE. 2013
  443. Identification of Residues and Domains of Raf Important for Function in Vivo and in Vitro. The Journal of Biological Chemistry. 2003
  444. Identification of Selective Small Molecule Inhibitors of the Nucleotide-Binding Oligomerization Domain 1 (NOD1) Signaling Pathway. PLoS ONE. 2014
  445. Identification of the Jak/Stat Proteins as Novel Downstream Targets of EphA4 Signaling in Muscle:IMPLICATIONS IN THE REGULATION OF ACETYLCHOLINESTERASE EXPRESSION. The Journal of Biological Chemistry. 2004
  446. Identification of YB-1 as a regulator of : PTP1B: expression: implications for regulation of insulin and cytokine signaling. The EMBO Journal. 2003
  447. IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation. The EMBO Journal. 2002
  448. IgE by Itself Affects Mature Rat Mast Cell Preformed and De Novo-Synthesized Mediator Release and Amplifies Mast Cell Migratory Response. PLoS ONE. 2013
  449. Imbalanced gp130-Dependent Signaling in Macrophages Alters Macrophage Colony-Stimulating Factor Responsiveness via Regulation of c-fms Expression. Molecular and Cellular Biology. 2004
  450. Immune Subversion by Mycobacterium tuberculosis through CCR5 Mediated Signaling: Involvement of IL-10. PLoS ONE. 2014
  451. Impaired Synergistic Activation of Stress-activated Protein Kinase SAPK/JNK in Mouse Embryonic Stem Cells Lacking SEK1/MKK4:DIFFERENT CONTRIBUTION OF SEK2/MKK7 ISOFORMS TO THE SYNERGISTIC ACTIVATION. The Journal of Biological Chemistry. 2001
  452. Implication of Phospholipase D2 in Oxidant-induced Phosphoinositide 3-Kinase Signaling via Pyk2 Activation in PC12 Cells. The Journal of Biological Chemistry. 2005
  453. In Vivo Activity of MiR-34a Mimics Delivered by Stable Nucleic Acid Lipid Particles (SNALPs) against Multiple Myeloma. PLoS ONE. 2014
  454. Inactivation of Platelet-derived Growth Factor Receptor by the Tumor Suppressor PTEN Provides a Novel Mechanism of Action of the Phosphatase. The Journal of Biological Chemistry. 2004
  455. Increased Susceptibility of Mice Lacking Clara Cell 10-kDa Protein to Lung Tumorigenesis by 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone, a Potent Carcinogen in Cigarette Smoke. The Journal of Biological Chemistry. 2004
  456. Independent and Cooperative Activation of Chromosomal c-fos Promoter by STAT3. The Journal of Biological Chemistry. 2003
  457. Induced Autocrine Signaling through the Epidermal Growth Factor Receptor Contributes to the Response of Mammary Epithelial Cells to Tumor Necrosis Factor %CE%B1. The Journal of Biological Chemistry. 2004
  458. Induction of Endothelial Nitric-oxide Synthase Phosphorylation by the Raloxifene Analog LY117018 Is Differentially Mediated by Akt and Extracellular Signal-regulated Protein Kinase in Vascular Endothelial Cells. The Journal of Biological Chemistry. 2001
  459. Induction of gp130-related Cytokines and Activation of JAK2/STAT3 Pathway in Astrocytes Precedes Up-regulation of Glial Fibrillary Acidic Protein in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Model of Neurodegeneration:KEY SIGNALING PATHWAY FOR ASTROGLIOSIS IN VIVO?. The Journal of Biological Chemistry. 2004
  460. Induction of Proinflammatory Responses in Macrophages by the Glycosylphosphatidylinositols of Plasmodium falciparum:THE REQUIREMENT OF EXTRACELLULAR SIGNAL-REGULATED KINASE, p38, c-Jun N-TERMINAL KINASE AND NF-%CE%BAB PATHWAYS FOR THE EXPRESSION OF PROINFLAMMATORY CYTOKINES AND NITRIC OXIDE. The Journal of Biological Chemistry. 2005
  461. Inefficient TLR4/MD-2 Heterotetramerization by Monophosphoryl Lipid A. PLoS ONE. 2013
  462. Inhalation of the BKCa-Opener NS1619 Attenuates Right Ventricular Pressure and Improves Oxygenation in the Rat Monocrotaline Model of Pulmonary Hypertension. PLoS ONE. 2014
  463. Inhibiting Heat Shock Protein 90 (HSP90) Limits the Formation of Liver Cysts Induced by Conditional Deletion of Pkd1 in Mice. PLoS ONE. 2014
  464. Inhibition of Cell Proliferation and Cell Cycle Progression by Specific Inhibition of Basal JNK Activity:EVIDENCE THAT MITOTIC Bcl-2 PHOSPHORYLATION IS JNK-INDEPENDENT. The Journal of Biological Chemistry. 2004
  465. Inhibition of ERK1/2 Worsens Intestinal Ischemia/Reperfusion Injury. PLoS ONE. 2013
  466. Inhibition of Geranylgeranylation Mediates the Effects of 3-Hydroxy-3-methylglutaryl (HMG)-CoA Reductase Inhibitors on Microglia. The Journal of Biological Chemistry. 2004
  467. Inhibition of HMC-1 Mast Cell Proliferation by Vitamin E:INVOLVEMENT OF THE PROTEIN KINASE B PATHWAY. The Journal of Biological Chemistry. 2004
  468. Inhibition of Inflammatory and Proliferative Responses of Human Keratinocytes Exposed to the Sesquiterpene Lactones Dehydrocostuslactone and Costunolide. PLoS ONE. 2014
  469. Inhibition of Insulin Receptor Catalytic Activity by the Molecular Adapter Grb14. The Journal of Biological Chemistry. 2002
  470. Inhibition of Mitogen-Activated Protein Kinase Erk1/2 Promotes Protein Degradation of ATP Binding Cassette Transporters A1 and G1 in CHO and HuH7 Cells. PLoS ONE. 2013
  471. Inhibition of Mitogen-activated Protein Kinase Kinase Induces Apoptosis of Human Chondrocytes. The Journal of Biological Chemistry. 2001
  472. Inhibition of Nerve Growth Factor-Induced Neurite Outgrowth from PC12 Cells by Dexamethasone: Signaling Pathways through the Glucocorticoid Receptor and Phosphorylated Akt and ERK1/2. PLoS ONE. 2014
  473. Inhibition of Phosphorylation of BAD and Raf-1 by Akt Sensitizes Human Ovarian Cancer Cells to Paclitaxel. The Journal of Biological Chemistry. 2002
  474. Inhibition of sPLA2-IIA Prevents LPS-Induced Neuroinflammation by Suppressing ERK1/2-cPLA2α Pathway in Mice Cerebral Cortex. PLoS ONE. 2013
  475. Inhibition of the JAK2/STAT3 Pathway Reduces Gastric Cancer Growth In Vitro and In Vivo. PLoS ONE. 2014
  476. Inhibition of Tumor Necrosis Factor %CE%B1-mediated NF%CE%BAB Activation and Leukocyte Adhesion, with Enhanced Endothelial Apoptosis, by G Protein-linked Receptor (TP) Ligands. The Journal of Biological Chemistry. 2003
  477. Inhibitory Effects of Resveratrol on PDGF-BB-Induced Retinal Pigment Epithelial Cell Migration via PDGFRβ, PI3K/Akt and MAPK pathways. PLoS ONE. 2013
  478. Inhibitory Effects of Vinpocetine on the Progression of Atherosclerosis Are Mediated by Akt/NF-κB Dependent Mechanisms in apoE-/- Mice. PLoS ONE. 2013
  479. Initiation and Transduction of Stretch-induced RhoA and Rac1 Activation through Caveolae:CYTOSKELETAL REGULATION OF ERK TRANSLOCATION. The Journal of Biological Chemistry. 2003
  480. Initiation Factor 2B Activity Is Regulated by Protein Phosphatase 1, Which Is Activated by the Mitogen-activated Protein Kinase-dependent Pathway in Insulin-like Growth Factor 1-stimulated Neuronal Cells. The Journal of Biological Chemistry. 2003
  481. Insulin Receptor Substrate 4 Associates with the Protein IRAS. The Journal of Biological Chemistry. 2002
  482. Insulin signaling controls the expression of O-GlcNAc transferase and its interaction with lipid microdomains. The FASEB Journal. 2013
  483. Insulin-like Growth Factor 1 (IGF-1)-induced Twist Expression Is Involved in the Anti-apoptotic Effects of the IGF-1 Receptor. The Journal of Biological Chemistry. 2001
  484. Insulin-like Growth Factor I (IGF-I)-induced Chronic Gliosis and Retinal Stress Lead to Neurodegeneration in a Mouse Model of Retinopathy. The Journal of Biological Chemistry. 2013
  485. Insulin-like Growth Factor-1 Regulates Endogenous RUNX2 Activity in Endothelial Cells through a Phosphatidylinositol 3-Kinase/ERK-dependent and Akt-independent Signaling Pathway. The Journal of Biological Chemistry. 2004
  486. Insulin-like Growth Factor-binding Protein-5 (IGFBP-5) Stimulates Growth and IGF-I Secretion in Human Intestinal Smooth Muscle by Ras-dependent Activation of p38 MAP Kinase and Erk1/2 Pathways. The Journal of Biological Chemistry. 2002
  487. Insulin-like Growth Factor-I Induces Renal Cell Hypertrophy via a Calcineurin-dependent Mechanism. The Journal of Biological Chemistry. 2001
  488. Integrin %CE%B12 and Extracellular Signal-regulated Kinase Are Functionally Linked in Highly Malignant Autocrine Transforming Growth Factor-%CE%B1-driven Colon Cancer Cells. The Journal of Biological Chemistry. 2003
  489. Integrin-linked Kinase Controls Neurite Outgrowth in N1E-115 Neuroblastoma Cells. The Journal of Biological Chemistry. 2001
  490. Interaction between Active Pak1 and Raf-1 Is Necessary for Phosphorylation and Activation of Raf-1. The Journal of Biological Chemistry. 2002
  491. Interaction between IGF-IR and ER Induced by E2 and IGF-I. PLoS ONE. 2013
  492. Interaction of Filamin A with the Insulin Receptor Alters Insulin-dependent Activation of the Mitogen-activated Protein Kinase Pathway. The Journal of Biological Chemistry. 2003
  493. Interferon-%CE%B3-induced Regulation of Peroxisome Proliferator-activated Receptor %CE%B3 and STATs in Adipocytes. The Journal of Biological Chemistry. 2001
  494. Interleukin-15 Prevents Mouse Mast Cell Apoptosis through STAT6-mediated Bcl-xL Expression. The Journal of Biological Chemistry. 2001
  495. Interleukin-17 Retinotoxicity Is Prevented by Gene Transfer of a Soluble Interleukin-17 Receptor Acting as a Cytokine Blocker: Implications for Age-Related Macular Degeneration. PLoS ONE. 2014
  496. Interleukin-22 (IL-22) Activates the JAK/STAT, ERK, JNK, and p38 MAP Kinase Pathways in a Rat Hepatoma Cell Line:PATHWAYS THAT ARE SHARED WITH AND DISTINCT FROM IL-10. The Journal of Biological Chemistry. 2002
  497. Internalization and Src Activity Regulate the Time Course of ERK Activation by Delta Opioid Receptor Ligands. The Journal of Biological Chemistry. 2005
  498. Intracellular Localization and Preassembly of the NADPH Oxidase Complex in Cultured Endothelial Cells. The Journal of Biological Chemistry. 2002
  499. Involvement of Both Gq/11 and Gs Proteins in Gonadotropin-releasing Hormone Receptor-mediated Signaling in L%CE%B2T2 Cells. The Journal of Biological Chemistry. 2002
  500. Involvement of Calcineurin in Transforming Growth Factor-%CE%B2-mediated Regulation of Extracellular Matrix Accumulation. The Journal of Biological Chemistry. 2004
  501. Involvement of Crm1 in Hepatitis B Virus X Protein-Induced Aberrant Centriole Replication and Abnormal Mitotic Spindles. Molecular and Cellular Biology. 2003
  502. Involvement of IRAK-M in Peptidoglycan-induced Tolerance in Macrophages. The Journal of Biological Chemistry. 2004
  503. Involvement of NADPH Oxidase Isoforms and Src Family Kinases in CD95-dependent Hepatocyte Apoptosis. The Journal of Biological Chemistry. 2005
  504. Involvement of the Annexin II-S100A10 Complex in the Formation of E-cadherin-based Adherens Junctions in Madin-Darby Canine Kidney Cells. The Journal of Biological Chemistry. 2005
  505. Involvement of the ERK Signaling Cascade in Protein Kinase C-mediated Cell Cycle Arrest in Intestinal Epithelial Cells. The Journal of Biological Chemistry. 2004
  506. IQGAP3 Promotes EGFR-ERK Signaling and the Growth and Metastasis of Lung Cancer Cells. PLoS ONE. 2014
  507. Irisin Promotes Human Umbilical Vein Endothelial Cell Proliferation through the ERK Signaling Pathway and Partly Suppresses High Glucose-Induced Apoptosis. PLoS ONE. 2014
  508. Isoproterenol Induces Vascular Oxidative Stress and Endothelial Dysfunction via a Giα-Coupled β2-Adrenoceptor Signaling Pathway. PLoS ONE. 2014
  509. Itk Phosphorylation Sites Are Required for Functional Activity in Primary T Cells. The Journal of Biological Chemistry. 2003
  510. JAK/STAT but Not ERK1/ERK2 Pathway Mediates Interleukin (IL)-6/Soluble IL-6R Down-regulation of Type II Collagen, Aggrecan Core, and Link Protein Transcription in Articular Chondrocytes:ASSOCIATION WITH A DOWN-REGULATION OF SOX9 EXPRESSION. The Journal of Biological Chemistry. 2003
  511. Janus Kinase 2 and Calcium Are Required for Angiotensin II-dependent Activation of Steroidogenic Acute Regulatory Protein Transcription in H295R Human Adrenocortical Cells. The Journal of Biological Chemistry. 2003
  512. Kinase Suppressor of Ras (KSR) Is a Scaffold Which Facilitates Mitogen-Activated Protein Kinase Activation In Vivo. Molecular and Cellular Biology. 2002
  513. Lactate Regulates Rat Male Germ Cell Function through Reactive Oxygen Species. PLoS ONE. 2014
  514. Laminin-1 Promotes Angiogenesis in Synergy with Fibroblast Growth Factor by Distinct Regulation of the Gene and Protein Expression Profile in Endothelial Cells. The Journal of Biological Chemistry. 2004
  515. Laminin-10/11 and Fibronectin Differentially Prevent Apoptosis Induced by Serum Removal via Phosphatidylinositol 3-Kinase/Akt- and MEK1/ERK-dependent Pathways. The Journal of Biological Chemistry. 2002
  516. LAMTOR2-Mediated Modulation of NGF/MAPK Activation Kinetics during Differentiation of PC12 Cells. PLoS ONE. 2014
  517. L-Arginine Stimulates Fibroblast Proliferation through the GPRC6A-ERK1/2 and PI3K/Akt Pathway. PLoS ONE. 2014
  518. Lefty Proteins Exhibit Unique Processing and Activate the MAPK Pathway. The Journal of Biological Chemistry. 2001
  519. Leptin Counteracts Sodium Butyrate-induced Apoptosis in Human Colon Cancer HT-29 Cells via NF-%CE%BAB Signaling. The Journal of Biological Chemistry. 2004
  520. Leptin Induces Apoptosis via ERK/cPLA2/Cytochrome c Pathway in Human Bone Marrow Stromal Cells. The Journal of Biological Chemistry. 2003
  521. Leptin Stimulates Tissue Inhibitor of Metalloproteinase-1 in Human Hepatic Stellate Cells:RESPECTIVE ROLES OF THE JAK/STAT AND JAK-MEDIATED H2O2-DEPENDENT MAPK PATHWAYS. The Journal of Biological Chemistry. 2004
  522. Leukemia-Related Transcription Factor TEL Is Negatively Regulated through Extracellular Signal-Regulated Kinase-Induced Phosphorylation. Molecular and Cellular Biology. 2004
  523. LFG-500 Inhibits the Invasion of Cancer Cells via Down-Regulation of PI3K/AKT/NF-κB Signaling Pathway. PLoS ONE. 2014
  524. LGI1, a Putative Tumor Metastasis Suppressor Gene, Controls in Vitro Invasiveness and Expression of Matrix Metalloproteinases in Glioma Cells through the ERK1/2 Pathway. The Journal of Biological Chemistry. 2004
  525. Licochalcone A Suppresses Migration and Invasion of Human Hepatocellular Carcinoma Cells through Downregulation of MKK4/JNK via NF-κB Mediated Urokinase Plasminogen Activator Expression. PLoS ONE. 2014
  526. Lifespan Extension in a Semelparous Chordate Occurs via Developmental Growth Arrest Just Prior to Meiotic Entry. PLoS ONE. 2014
  527. Ligand-regulated Chimeric Receptor Approach Reveals Distinctive Subcellular Localization and Signaling Properties of the Toll-like Receptors. The Journal of Biological Chemistry. 2004
  528. Live Attenuated B. pertussis BPZE1 Rescues the Immune Functions of Respiratory Syncytial Virus Infected Human Dendritic Cells by Promoting Th1/Th17 Responses. PLoS ONE. 2014
  529. Long-Term Artificial Sweetener Acesulfame Potassium Treatment Alters Neurometabolic Functions in C57BL/6J Mice. PLoS ONE. 2013
  530. Long-Time Treatment by Low-Dose N-Acetyl-L-Cysteine Enhances Proinflammatory Cytokine Expressions in LPS-Stimulated Macrophages. PLoS ONE. 2014
  531. Loss of Intralipid?- but Not Sevoflurane-Mediated Cardioprotection in Early Type-2 Diabetic Hearts of Fructose-Fed Rats: Importance of ROS Signaling. PLoS ONE. 2014
  532. Loss of JunB Activity Enhances Stromelysin 1 Expression in a Model of the Epithelial-to-Mesenchymal Transition of Mouse Skin Tumors. Molecular and Cellular Biology. 2001
  533. Loss of Plasma Membrane Phospholipid Asymmetry Requires Raft Integrity:ROLE OF TRANSIENT RECEPTOR POTENTIAL CHANNELS AND ERK PATHWAY. The Journal of Biological Chemistry. 2002
  534. Low Concentrations of Metformin Selectively Inhibit CD133+ Cell Proliferation in Pancreatic Cancer and Have Anticancer Action. PLoS ONE. 2013
  535. Low Energy Shock Wave Therapy Induces Angiogenesis in Acute Hind-Limb Ischemia via VEGF Receptor 2 Phosphorylation. PLoS ONE. 2014
  536. Low Molecular Weight Hyaluronan Induces Lymphangiogenesis through LYVE-1-Mediated Signaling Pathways. PLoS ONE. 2014
  537. Lung Cancer Cells That Survive Ionizing Radiation Show Increased Integrin α2β1- and EGFR-Dependent Invasiveness. PLoS ONE. 2013
  538. Lymphocyte Function-associated Antigen-1-mediated T Cell Adhesion Is Impaired by Low Molecular Weight Phosphotyrosine Phosphatase-dependent Inhibition of FAK Activity. The Journal of Biological Chemistry. 2003
  539. Lysosomal Function Is Involved in 17β-Estradiol-Induced Estrogen Receptor α Degradation and Cell Proliferation. PLoS ONE. 2014
  540. Manganese Superoxide Dismutase Signals Matrix Metalloproteinase Expression via H2O2-dependent ERK1/2 Activation. The Journal of Biological Chemistry. 2001
  541. Mannose Phosphate Isomerase Regulates Fibroblast Growth Factor Receptor Family Signaling and Glioma Radiosensitivity. PLoS ONE. 2014
  542. MAP Kinase Phosphatase 3 (MKP3) Interacts with and Is Phosphorylated by Protein Kinase CK2%CE%B1. The Journal of Biological Chemistry. 2004
  543. MAP Kinase Stimulation by cAMP Does Not Require RAP1 but SRC Family Kinases. The Journal of Biological Chemistry. 2002
  544. MAPK-mediated Phosphorylation of GATA-1 Promotes Bcl-XL Expression and Cell Survival. The Journal of Biological Chemistry. 2005
  545. Maternal Inheritance of Twist and Analysis of MAPK Activation in Embryos of the Polychaete Annelid Platynereis dumerilii. PLoS ONE. 2014
  546. Matrix Metalloproteinases 2 and 9 Mediate Epidermal Growth Factor Receptor Transactivation by Gonadotropin-releasing Hormone. The Journal of Biological Chemistry. 2003
  547. Mechanical Regulation of Mitogen-activated Protein Kinase Signaling in Articular Cartilage. The Journal of Biological Chemistry. 2003
  548. Mechanical Strain Differentially Regulates Endothelial Nitric-oxide Synthase and Receptor Activator of Nuclear %CE%BAB Ligand Expression via ERK1/2 MAPK. The Journal of Biological Chemistry. 2003
  549. Mechanism of Human Dermal Fibroblast Migration Driven by Type I Collagen and Platelet-derived Growth Factor-BB. Molecular Biology of the Cell. 2004
  550. Mechanisms Involving Ang II and MAPK/ERK1/2 Signaling Pathways Underlie Cardiac and Renal Alterations during Chronic Undernutrition. PLoS ONE. 2014
  551. Mechanisms of Protease-activated Receptor-4 Actions in Cardiomyocytes:ROLE OF Src TYROSINE KINASE. The Journal of Biological Chemistry. 2003
  552. Medulloblastoma Sensitivity to 17-Allylamino-17-demethoxygeldanamycin Requires MEK/ERK. The Journal of Biological Chemistry. 2003
  553. MEK Is a Key Modulator for TLR5-induced Interleukin-8 and MIP3%CE%B1 Gene Expression in Non-transformed Human Colonic Epithelial Cells. The Journal of Biological Chemistry. 2004
  554. MEK Kinase 2 and the Adaptor Protein Lad Regulate Extracellular Signal-Regulated Kinase 5 Activation by Epidermal Growth Factor via Src. Molecular and Cellular Biology. 2003
  555. MEK Mediates v-Src-induced Disruption of the Actin Cytoskeleton via Inactivation of the Rho-ROCK-LIM Kinase Pathway. The Journal of Biological Chemistry. 2002
  556. MEK6 Regulates Human Involucrin Gene Expression via a p38%CE%B1- and p38%CE%B4-dependent Mechanism. The Journal of Biological Chemistry. 2001
  557. MEK-ERK Signaling Controls Hdm2 Oncoprotein Expression by Regulating hdm2 mRNA Export to the Cytoplasm. The Journal of Biological Chemistry. 2005
  558. Metalloproteinases and Transforming Growth Factor-%CE%B1 Mediate Substance P-induced Mitogen-activated Protein Kinase Activation and Proliferation in Human Colonocytes. The Journal of Biological Chemistry. 2004
  559. Mice Devoid of Fer Protein-Tyrosine Kinase Activity Are Viable and Fertile but Display Reduced Cortactin Phosphorylation. Molecular and Cellular Biology. 2001
  560. MicroRNA-31 Activates the RAS Pathway and Functions as an Oncogenic MicroRNA in Human Colorectal Cancer by Repressing RAS p21 GTPase Activating Protein 1 (RASA1). The Journal of Biological Chemistry. 2013
  561. MicroRNA-92a Negatively Regulates Toll-like Receptor (TLR)-triggered Inflammatory Response in Macrophages by Targeting MKK4 Kinase. The Journal of Biological Chemistry. 2013
  562. Microvesicles Derived from Human Wharton’s Jelly Mesenchymal Stem Cells Promote Human Renal Cancer Cell Growth and Aggressiveness through Induction of Hepatocyte Growth Factor. PLoS ONE. 2014
  563. Midkine Binds to Anaplastic Lymphoma Kinase (ALK) and Acts as a Growth Factor for Different Cell Types. The Journal of Biological Chemistry. 2002
  564. Minocycline Blocks Asthma-associated Inflammation in Part by Interfering with the T Cell Receptor-Nuclear Factor %CE%BAB-GATA-3-IL-4 Axis without a Prominent Effect on Poly(ADP-ribose) Polymerase. The Journal of Biological Chemistry. 2013
  565. Minocycline Suppresses Interleukine-6, Its Receptor System and Signaling Pathways and Impairs Migration, Invasion and Adhesion Capacity of Ovarian Cancer Cells: In Vitro and In Vivo Studies. PLoS ONE. 2013
  566. miR-126&126* Restored Expressions Play a Tumor Suppressor Role by Directly Regulating ADAM9 and MMP7 in Melanoma. PLoS ONE. 2013
  567. MiR-200c Increases the Radiosensitivity of Non-Small-Cell Lung Cancer Cell Line A549 by Targeting VEGF-VEGFR2 Pathway. PLoS ONE. 2013
  568. miR-203 Suppresses the Proliferation and Migration and Promotes the Apoptosis of Lung Cancer Cells by Targeting SRC. PLoS ONE. 2014
  569. MiR-330-Mediated Regulation of SH3GL2 Expression Enhances Malignant Behaviors of Glioblastoma Stem Cells by Activating ERK and PI3K/AKT Signaling Pathways. PLoS ONE. 2014
  570. Mitogen-activated Protein Kinase Phosphorylates and Targets Inducible cAMP Early Repressor to Ubiquitin-mediated Destruction. The Journal of Biological Chemistry. 2001
  571. Mitogen-activated Protein Kinases and Mitogen-activated Protein Kinase Phosphatases Mediate the Inhibitory Effects of All-trans Retinoic Acid on the Hypertrophic Growth of Cardiomyocytes. The Journal of Biological Chemistry. 2004
  572. Modification of Ligand-independent B Cell Receptor Tonic Signals Activates Receptor Editing in Immature B Lymphocytes. The Journal of Biological Chemistry. 2004
  573. Modulation of Pro-inflammatory Gene Expression by Nuclear Lysophosphatidic Acid Receptor Type-1. The Journal of Biological Chemistry. 2003
  574. Modulatory Effects of Vasoactive Intestinal Peptide on Intestinal Mucosal Immunity and Microbial Community of Weaned Piglets Challenged by an Enterotoxigenic Escherichia coli (K88). PLoS ONE. 2014
  575. Molecular Analysis of a Mutated FSH Receptor Detected in a Patient with Spontaneous Ovarian Hyperstimulation Syndrome. PLoS ONE. 2013
  576. Molecular Cross-talk between MEK1/2 and mTOR Signaling during Recovery of 293 Cells from Hypertonic Stress. The Journal of Biological Chemistry. 2004
  577. Monokine Induced by Interferon-%CE%B3 Acts as a Neurotrophic Factor on PC12 Cells and Rat Primary Sympathetic Neurons. The Journal of Biological Chemistry. 2005
  578. MSLN Gene Silencing Has an Anti-Malignant Effect on Cell Lines Overexpressing Mesothelin Deriving from Malignant Pleural Mesothelioma. PLoS ONE. 2014
  579. MUC1-C Oncoprotein Activates ERK%E2%86%92C/EBP%CE%B2 Signaling and Induction of Aldehyde Dehydrogenase 1A1 in Breast Cancer Cells. The Journal of Biological Chemistry. 2013
  580. Multiple coagulation factor deficiency protein 2 contains the ability to support stem cell self-renewal. The FASEB Journal. 2013
  581. Multiple Members of the Mitogen-activated Protein Kinase Family Are Necessary for PED/PEA-15 Anti-apoptotic Function. The Journal of Biological Chemistry. 2002
  582. Multiple Regions of Internalin B Contribute to Its Ability to Turn on the Ras-Mitogen-activated Protein Kinase Pathway. The Journal of Biological Chemistry. 2003
  583. Mutation of B-Raf in Human Choroidal Melanoma Cells Mediates Cell Proliferation and Transformation through the MEK/ERK Pathway. The Journal of Biological Chemistry. 2003
  584. Mutation of Threonine 766 in the Epidermal Growth Factor Receptor Reveals a Hotspot for Resistance Formation against Selective Tyrosine Kinase Inhibitors. The Journal of Biological Chemistry. 2003
  585. Mutually Exclusive Subsets of BH3-Only Proteins Are Activated by the p53 and c-Jun N-Terminal Kinase/c-Jun Signaling Pathways during Cortical Neuron Apoptosis Induced by Arsenite. Molecular and Cellular Biology. 2005
  586. Mycobacteria Bypass Mucosal NF-kB Signalling to Induce an Epithelial Anti-Inflammatory IL-22 and IL-10 Response. PLoS ONE. 2014
  587. Myeloid-Specific Rictor Deletion Induces M1 Macrophage Polarization and Potentiates In Vivo Pro-Inflammatory Response to Lipopolysaccharide. PLoS ONE. 2014
  588. Myeloperoxidase-Derived Oxidants Induce Blood-Brain Barrier Dysfunction In Vitro and In Vivo. PLoS ONE. 2013
  589. Myocardial Ischemia and Increased Heart Work Modulate the Phosphorylation State of Eukaryotic Elongation Factor-2. The Journal of Biological Chemistry. 2003
  590. Myocilin Stimulates Osteogenic Differentiation of Mesenchymal Stem Cells through Mitogen-activated Protein Kinase Signaling. The Journal of Biological Chemistry. 2013
  591. Nardosinone Improves the Proliferation, Migration and Selective Differentiation of Mouse Embryonic Neural Stem Cells. PLoS ONE. 2014
  592. Negative Regulation of ERK and Elk by Protein Kinase B Modulates c-fos Transcription. The Journal of Biological Chemistry. 2003
  593. Negative Regulation of Grb10 Interacting GYF Protein 2 on Insulin-Like Growth Factor-1 Receptor Signaling Pathway Caused Diabetic Mice Cognitive Impairment. PLoS ONE. 2014
  594. Nerve Growth Factor Activation of Erk-1 and Erk-2 Induces Matrix Metalloproteinase-9 Expression in Vascular Smooth Muscle Cells. The Journal of Biological Chemistry. 2002
  595. Nerve Growth Factor Uses Ras/ERK and Phosphatidylinositol 3-Kinase Cascades to Up-regulate theN-Methyl-d-aspartate Receptor 1 Promoter. The Journal of Biological Chemistry. 2001
  596. Neurodegeneration in Heterozygous Niemann-Pick Type C1 (NPC1) Mouse:IMPLICATION OF HETEROZYGOUS NPC1 MUTATIONS BEING A RISK FOR TAUOPATHY. The Journal of Biological Chemistry. 2005
  597. Neurokinin-1 Receptor Directly Mediates Glioma Cell Migration by Up-regulation of Matrix Metalloproteinase-2 (MMP-2) and Membrane Type 1-Matrix Metalloproteinase (MT1-MMP). The Journal of Biological Chemistry. 2013
  598. Neuropeptide-induced Transactivation of a Neuronal Epidermal Growth Factor Receptor Is Mediated by Metalloprotease-dependent Formation of Heparin-binding Epidermal Growth Factor. The Journal of Biological Chemistry. 2004
  599. New Function of the Adaptor Protein SH2B1 in Brain-Derived Neurotrophic Factor-Induced Neurite Outgrowth. PLoS ONE. 2013
  600. Nicotinamide Mononucleotide, an Intermediate of NAD+ Synthesis, Protects the Heart from Ischemia and Reperfusion. PLoS ONE. 2014
  601. Nicotine Induces Multi-site Phosphorylation of Bad in Association with Suppression of Apoptosis. The Journal of Biological Chemistry. 2004
  602. Nitric Oxide Affects ERK Signaling through Down-Regulation of MAP Kinase Phosphatase Levels during Larval Development of the Ascidian Ciona intestinalis. PLoS ONE. 2014
  603. N-myc Downstream-regulated Gene 1 Promotes Tumor Inflammatory Angiogenesis through JNK Activation and Autocrine Loop of Interleukin-1%CE%B1 by Human Gastric Cancer Cells. The Journal of Biological Chemistry. 2013
  604. No Evidence for Activated Autophagy in Left Ventricular Myocardium at Early Reperfusion with Protection by Remote Ischemic Preconditioning in Patients Undergoing Coronary Artery Bypass Grafting. PLoS ONE. 2014
  605. Non-redundant Signal Transduction of Interleukin-6-type Cytokines:THE ADAPTER PROTEIN Shc IS SPECIFICALLY RECRUITED TO THE ONCOSTATIN M RECEPTOR. The Journal of Biological Chemistry. 2000
  606. Non-steroidal Anti-inflammatory Drugs Inhibit Nitric Oxide-induced Apoptosis and Dedifferentiation of Articular Chondrocytes Independent of Cyclooxygenase Activity. The Journal of Biological Chemistry. 2003
  607. Nonsteroidal Anti-inflammatory Drugs Suppress T-cell Activation by Inhibiting p38 MAPK Induction. The Journal of Biological Chemistry. 2002
  608. Novel Mechanisms of Sildenafil in Pulmonary Hypertension Involving Cytokines/Chemokines, MAP Kinases and Akt. PLoS ONE. 2014
  609. Novel Role for JNK as a Stress-activated Bcl2 Kinase. The Journal of Biological Chemistry. 2001
  610. Nox4 NAD(P)H Oxidase Mediates Hypertrophy and Fibronectin Expression in the Diabetic Kidney. The Journal of Biological Chemistry. 2005
  611. NPM1 Silencing Reduces Tumour Growth and MAPK Signalling in Prostate Cancer Cells. PLoS ONE. 2014
  612. NR4A1 Promotes PDGF-BB-Induced Cell Colony Formation in Soft Agar. PLoS ONE. 2014
  613. Nuclear Factor-inducing Kinase Plays a Crucial Role in Osteopontin-induced MAPK/I%CE%BAB%CE%B1 Kinase-dependent Nuclear Factor %CE%BAB-mediated Promatrix Metalloproteinase-9 Activation. The Journal of Biological Chemistry. 2004
  614. Nutritional Intervention Restores Muscle but Not Kidney Phenotypes in Adult Calcineurin Aα Null Mice. PLoS ONE. 2013
  615. O-GlcNAcylation-Inducing Treatments Inhibit Estrogen Receptor α Expression and Confer Resistance to 4-OH-Tamoxifen in Human Breast Cancer-Derived MCF-7 Cells. PLoS ONE. 2013
  616. Oligodendrocyte Precursor Cells Support Blood-Brain Barrier Integrity via TGF-β Signaling. PLoS ONE. 2014
  617. On the Physiological Importance of Endoproteolysis of CAAX Proteins:HEART-SPECIFIC RCE1 KNOCKOUT MICE DEVELOP A LETHAL CARDIOMYOPATHY. The Journal of Biological Chemistry. 2004
  618. Oncostatin M Mediates STAT3-Dependent Intestinal Epithelial Restitution via Increased Cell Proliferation, Decreased Apoptosis and Upregulation of SERPIN Family Members. PLoS ONE. 2014
  619. Opening of Astrocytic Mitochondrial ATP-Sensitive Potassium Channels Upregulates Electrical Coupling between Hippocampal Astrocytes in Rat Brain Slices. PLoS ONE. 2013
  620. Opioid-Induced Mitogen-Activated Protein Kinase Signaling in Rat Enteric Neurons following Chronic Morphine Treatment. PLoS ONE. 2014
  621. Opposing Effects of PI3K/Akt and Smad-Dependent Signaling Pathways in NAG-1-Induced Glioblastoma Cell Apoptosis. PLoS ONE. 2014
  622. Opposing Roles of C/EBP%CE%B2 and AP-1 in the Control of Fibroblast Proliferation and Growth Arrest-specific Gene Expression. The Journal of Biological Chemistry. 2003
  623. Osteopontin Gene Regulation by Oscillatory Fluid Flow via Intracellular Calcium Mobilization and Activation of Mitogen-activated Protein Kinase in MC3T3%E2%80%93E1 Osteoblasts. The Journal of Biological Chemistry. 2001
  624. Osteopontin Induces AP-1-mediated Secretion of Urokinase-type Plasminogen Activator through c-Src-dependent Epidermal Growth Factor Receptor Transactivation in Breast Cancer Cells. The Journal of Biological Chemistry. 2004
  625. Osteopontin Regulation by Inorganic Phosphate Is ERK1/2-, Protein Kinase C-, and Proteasome-dependent. The Journal of Biological Chemistry. 2003
  626. OVA66, a Tumor Associated Protein, Induces Oncogenic Transformation of NIH3T3 Cells. PLoS ONE. 2014
  627. Overexpression of Aldehyde Dehydrogenase-2 (ALDH2) Transgene Prevents Acetaldehyde-induced Cell Injury in Human Umbilical Vein Endothelial Cells:ROLE OF ERK AND p38 MITOGEN-ACTIVATED PROTEIN KINASE. The Journal of Biological Chemistry. 2004
  628. Overexpression of Kinase Suppressor of Ras Upregulates the High-Molecular-Weight Tropomyosin Isoforms in ras-Transformed NIH 3T3 Fibroblasts. Molecular and Cellular Biology. 2003
  629. Overexpression of N-Acetylglucosaminyltransferase III Enhances the Epidermal Growth Factor-induced Phosphorylation of ERK in HeLaS3 Cells by Up-regulation of the Internalization Rate of the Receptors. The Journal of Biological Chemistry. 2001
  630. Overexpression of the Protein Phosphatase 2A Regulatory Subunit B%CE%B3 Promotes Neuronal Differentiation by Activating the MAP Kinase (MAPK) Cascade. The Journal of Biological Chemistry. 2002
  631. Oxidative Stress Induces Protein Kinase C-mediated Activation Loop Phosphorylation and Nuclear Redistribution of Protein Kinase D. The Journal of Biological Chemistry. 2004
  632. Oxidized Low Density Lipoprotein Inhibits Macrophage Apoptosis by Blocking Ceramide Generation, Thereby Maintaining Protein Kinase B Activation and Bcl-XL Levels. The Journal of Biological Chemistry. 2003
  633. p150Glued, Dynein, and Microtubules Are Specifically Required for Activation of MKK3/6 and p38 MAPKs. The Journal of Biological Chemistry. 2004
  634. p21Cip1 Gene Expression Is Modulated by Egr1:A NOVEL REGULATORY MECHANISM INVOLVED IN THE RESVERATROL ANTIPROLIFERATIVE EFFECT. The Journal of Biological Chemistry. 2003
  635. p27Kip1 Inhibition of GRB2-SOS Formation Can Regulate Ras Activation. Molecular and Cellular Biology. 2003
  636. P2Y6 Receptor-Mediated Proinflammatory Signaling in Human Bronchial Epithelia. PLoS ONE. 2014
  637. p38 and ERK1/2 Coordinate Cellular Migration and Proliferation in Epithelial Wound Healing:EVIDENCE OF CROSS-TALK ACTIVATION BETWEEN MAP KINASE CASCADES. The Journal of Biological Chemistry. 2003
  638. p38 Kinase-dependent and -independent Inhibition of Protein Kinase C %CE%B6 and -%CE%B1 Regulates Nitric Oxide-induced Apoptosis and Dedifferentiation of Articular Chondrocytes. The Journal of Biological Chemistry. 2002
  639. p38 MAPK Is Involved in Activin A- and Hepatocyte Growth Factor-mediated Expression of Pro-endocrine Gene Neurogenin 3 in AR42J-B13 Cells. The Journal of Biological Chemistry. 2003
  640. p38 Mitogen-activated Protein Kinase Mediates Hypoxic Regulation of Mdm2 and p53 in Neurons. The Journal of Biological Chemistry. 2002
  641. p38%CE%B1 Isoform Mxi2 Binds to Extracellular Signal-Regulated Kinase 1 and 2 Mitogen-Activated Protein Kinase and Regulates Its Nuclear Activity by Sustaining Its Phosphorylation Levels. Molecular and Cellular Biology. 2003
  642. p38%CE%B1 Mitogen-Activated Protein Kinase Depletion and Repression of Signal Transduction to Translation Machinery by miR-124 and -128 in Neurons. Molecular and Cellular Biology. 2013
  643. p38%CE%B1 Mitogen-Activated Protein Kinase Plays a Critical Role in Cardiomyocyte Survival but Not in Cardiac Hypertrophic Growth in Response to Pressure Overload. Molecular and Cellular Biology. 2004
  644. p38MAPK Acts in the BMP7-dependent Stimulatory Pathway during Epithelial Cell Morphogenesis and Is Regulated by Smad1. The Journal of Biological Chemistry. 2004
  645. p38α Mitogen-activated Protein Kinase Sensitizes Cells to Apoptosis Induced by Different Stimuli. Molecular Biology of the Cell. 2004
  646. Pak2 Kinase Restrains Mast Cell Fc%CF%B5RI Receptor Signaling through Modulation of Rho Protein Guanine Nucleotide Exchange Factor (GEF) Activity. The Journal of Biological Chemistry. 2013
  647. Palmitoylation of the V2 Vasopressin Receptor Carboxyl Tail Enhances %CE%B2-Arrestin Recruitment Leading to Efficient Receptor Endocytosis and ERK1/2 Activation. The Journal of Biological Chemistry. 2003
  648. PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate. The EMBO Journal. 2004
  649. Parathyroid Hormone Receptor Trafficking Contributes to the Activation of Extracellular Signal-regulated Kinases but Is Not Required for Regulation of cAMP Signaling. The Journal of Biological Chemistry. 2005
  650. Parathyroid Hormone Uses Multiple Mechanisms to Arrest the Cell Cycle Progression of Osteoblastic Cells from G1 to S Phase. The Journal of Biological Chemistry. 2005
  651. Parathyroid Hormone-related Peptide Stimulates Osteogenic Cell Proliferation through Protein Kinase C Activation of the Ras/Mitogen-activated Protein Kinase Signaling Pathway. The Journal of Biological Chemistry. 2001
  652. Partial Deletion of eNOS Gene Causes Hyperinsulinemic State, Unbalance of Cardiac Insulin Signaling Pathways and Coronary Dysfunction Independently of High Fat Diet. PLoS ONE. 2014
  653. Pasteurella multocida Toxin-induced Activation of RhoA Is Mediated via Two Families of G%CE%B1 Proteins, G%CE%B1q and G%CE%B112/13. The Journal of Biological Chemistry. 2005
  654. Pathological Prion Protein Exposure Switches on Neuronal Mitogen-activated Protein Kinase Pathway Resulting in Microglia Recruitment. The Journal of Biological Chemistry. 2005
  655. Pathway of Programmed Cell Death and Oxidative Stress Induced by β-Hydroxybutyrate in Dairy Cow Abomasum Smooth Muscle Cells and in Mouse Gastric Smooth Muscle. PLoS ONE. 2014
  656. PE-1/METS, an Antiproliferative Ets Repressor Factor, Is Induced by CREB-1/CREM-1 during Macrophage Differentiation. The Journal of Biological Chemistry. 2004
  657. PEA-15 Binding to ERK1/2 MAPKs Is Required for Its Modulation of Integrin Activation. The Journal of Biological Chemistry. 2003
  658. PEA-15 Is Inhibited by Adenovirus E1A and Plays a Role in ERK Nuclear Export and Ras-induced Senescence. The Journal of Biological Chemistry. 2004
  659. Periplakin Interferes with G Protein Activation by the Melanin-concentrating Hormone Receptor-1 by Binding to the Proximal Segment of the Receptor C-terminal Tail. The Journal of Biological Chemistry. 2005
  660. Persistent Nicotine Treatment Potentiates Amplification of the Dihydrofolate Reductase Gene in Rat Lung Epithelial Cells as a Consequence of Ras Activation. The Journal of Biological Chemistry. 2005
  661. Persistent TrkA Activity Is Necessary to Maintain Transcription in Neuronally Differentiated PC12 Cells. The Journal of Biological Chemistry. 2003
  662. PGE2 Promotes Apoptosis Induced by Cytokine Deprivation through EP3 Receptor and Induces Bim in Mouse Mast Cells. PLoS ONE. 2014
  663. Phenotypic Spectrum Caused by Transgenic Overexpression of Activated Akt in the Heart. The Journal of Biological Chemistry. 2002
  664. Phosphodiesterase IV Inhibition by Piclamilast Potentiates the Cytodifferentiating Action of Retinoids in Myeloid Leukemia Cells:CROSS-TALK BETWEEN THE cAMP AND THE RETINOIC ACID SIGNALING PATHWAYS. The Journal of Biological Chemistry. 2004
  665. Phosphoinositide 3-Kinase-dependent Regulation of Interleukin-3-induced Proliferation:INVOLVEMENT OF MITOGEN-ACTIVATED PROTEIN KINASES, SHP2 AND Gab2. The Journal of Biological Chemistry. 2001
  666. Phospholipase C-%CE%B31 Is Required for the Induction of Immediate Early Genes by Platelet-derived Growth Factor. The Journal of Biological Chemistry. 2001
  667. Phospholipase D Is Required in the Signaling Pathway Leading to p38 MAPK Activation in Neutrophil-like HL-60 Cells, Stimulated by N-Formyl-methionyl-leucyl-phenylalanine. The Journal of Biological Chemistry. 2001
  668. Phospholipase D Isozymes Mediate Epigallocatechin Gallate-induced Cyclooxygenase-2 Expression in Astrocyte Cells. The Journal of Biological Chemistry. 2004
  669. Phosphophoryn Regulates the Gene Expression and Differentiation of NIH3T3, MC3T3-E1, and Human Mesenchymal Stem Cells via the Integrin/MAPK Signaling Pathway. The Journal of Biological Chemistry. 2004
  670. Phosphorylation and Action of the Immunomodulator FTY720 Inhibits Vascular Endothelial Cell Growth Factor-induced Vascular Permeability. The Journal of Biological Chemistry. 2003
  671. Phosphorylation by Mitogen-activated Protein Kinase Mediates the Hypoxia-induced Turnover of the TAL1/SCL Transcription Factor in Endothelial Cells. The Journal of Biological Chemistry. 2002
  672. Phosphorylation of C/EBP%CE%B1 Inhibits Granulopoiesis. Molecular and Cellular Biology. 2004
  673. Phosphorylation of MafA Is Essential for Its Transcriptional and Biological Properties. Molecular and Cellular Biology. 2001
  674. Phosphorylation of p90 Ribosomal S6 Kinase (RSK) Regulates Extracellular Signal-Regulated Kinase Docking and RSK Activity. Molecular and Cellular Biology. 2003
  675. Phosphorylation of Pax2 by the c-Jun N-terminal Kinase and Enhanced Pax2-dependent Transcription Activation. The Journal of Biological Chemistry. 2002
  676. Phosphorylation of Serine 147 of tis21/BTG2/pc3 by p-Erk1/2 Induces Pin-1 Binding in Cytoplasm and Cell Death. The Journal of Biological Chemistry. 2005
  677. Phosphorylation of STAT-3 in Response to Basic Fibroblast Growth Factor Occurs through a Mechanism Involving Platelet-activating Factor, JAK-2, and Src in Human Umbilical Vein Endothelial Cells:EVIDENCE FOR A DUAL KINASE MECHANISM. The Journal of Biological Chemistry. 2002
  678. Phosphorylation of the Gq/11-coupled M3-Muscarinic Receptor Is Involved in Receptor Activation of the ERK-1/2 Mitogen-activated Protein Kinase Pathway. The Journal of Biological Chemistry. 2001
  679. Phosphorylation of the Head Domain of Neurofilament Protein (NF-M):A FACTOR REGULATING TOPOGRAPHIC PHOSPHORYLATION OF NF-M TAIL DOMAIN KSP SITES IN NEURONS. The Journal of Biological Chemistry. 2003
  680. Phosphorylation of Threonine 290 in the Activation Loop of Tpl2/Cot Is Necessary but Not Sufficient for Kinase Activity. The Journal of Biological Chemistry. 2004
  681. Phosphorylation of Tumor Necrosis Factor Receptor 1 (p55) Protects Macrophages from Silica-induced Apoptosis. The Journal of Biological Chemistry. 2004
  682. Phosphorylation of Tyrosine 319 of the Angiotensin II Type 1 Receptor Mediates Angiotensin II-induced Trans-activation of the Epidermal Growth Factor Receptor. The Journal of Biological Chemistry. 2003
  683. Phosphorylation Regulates the Nucleocytoplasmic Distribution of Kinase Suppressor of Ras. The Journal of Biological Chemistry. 2002
  684. Phosphorylation-regulated Cleavage of the Tumor Suppressor PTEN by Caspase-3:IMPLICATIONS FOR THE CONTROL OF PROTEIN STABILITY AND PTEN-PROTEIN INTERACTIONS. The Journal of Biological Chemistry. 2003
  685. Photo-Activated Psoralen Binds the ErbB2 Catalytic Kinase Domain, Blocking ErbB2 Signaling and Triggering Tumor Cell Apoptosis. PLoS ONE. 2014
  686. Pigment Epithelium-Derived Factor 34-mer Peptide Prevents Liver Fibrosis and Hepatic Stellate Cell Activation through Down-Regulation of the PDGF Receptor. PLoS ONE. 2014
  687. PIMT Prevents the Apoptosis of Endothelial Cells in Response to Glycated Low Density Lipoproteins and Protective Effects of Grape Seed Procyanidin B2. PLoS ONE. 2013
  688. PKC controls HGF-dependent c-Met traffic, signalling and cell migration. The EMBO Journal. 2004
  689. Platelet-derived Growth Factor (PDGF)-C, a PDGF Family Member with a Vascular Endothelial Growth Factor-like Structure. The Journal of Biological Chemistry. 2003
  690. Platelet-derived Growth Factor-BB-mediated Activation of Akt Suppresses Smooth Muscle-specific Gene Expression through Inhibition of Mitogen-activated Protein Kinase and Redistribution of Serum Response Factor. The Journal of Biological Chemistry. 2003
  691. Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line. The EMBO Journal. 2002
  692. PLEKHG2 Promotes Heterotrimeric G Protein %CE%B2%CE%B3-Stimulated Lymphocyte Migration via Rac and Cdc42 Activation and Actin Polymerization. Molecular and Cellular Biology. 2013
  693. Polyunsaturated Fatty Acids Block Dendritic Cell Activation and Function Independently of NF-%CE%BAB Activation. The Journal of Biological Chemistry. 2005
  694. Possible Contribution of Taurine to Distorted Glucagon Secretion in Intra-Islet Insulin Deficiency: A Metabolome Analysis Using a Novel α-Cell Model of Insulin-Deficient Diabetes. PLoS ONE. 2014
  695. Potent Anti-Cancer Effect of 3′-Hydroxypterostilbene in Human Colon Xenograft Tumors. PLoS ONE. 2014
  696. Potential Involvement of Extracellular Signal-regulated Kinase 1 and 2 in Encystation of a Primitive Eukaryote, Giardia lamblia:STAGE-SPECIFIC ACTIVATION AND INTRACELLULAR LOCALIZATION. The Journal of Biological Chemistry. 2003
  697. PP4 Is Essential for Germinal Center Formation and Class Switch Recombination in Mice. PLoS ONE. 2014
  698. Presenilin-dependent %CE%B3-Secretase Processing Regulates Multiple ERBB4/HER4 Activities. The Journal of Biological Chemistry. 2005
  699. Prevention of Kidney Ischemia/Reperfusion-induced Functional Injury and JNK, p38, and MAPK Kinase Activation by Remote Ischemic Pretreatment. The Journal of Biological Chemistry. 2001
  700. Prevention of Kidney Ischemia/Reperfusion-induced Functional Injury, MAPK and MAPK Kinase Activation, and Inflammation by Remote Transient Ureteral Obstruction. The Journal of Biological Chemistry. 2002
  701. Prolonged Calcitonin Receptor Signaling by Salmon, but Not Human Calcitonin, Reveals Ligand Bias. PLoS ONE. 2014
  702. Prolonged Nuclear Retention of Activated Extracellular Signal-regulated Kinase 1/2 Is Required for Hepatocyte Growth Factor-induced Cell Motility. The Journal of Biological Chemistry. 2002
  703. Propagation of Human Prostate Cancer Stem-Like Cells Occurs through EGFR-Mediated ERK Activation. PLoS ONE. 2013
  704. Prostaglandin A2-mediated Stabilization of p21 mRNA through an ERK-dependent Pathway Requiring the RNA-binding Protein HuR. The Journal of Biological Chemistry. 2004
  705. Prostaglandin E2 Induced Functional Expression of Early Growth Response Factor-1 by EP4, but Not EP2, Prostanoid Receptors via the Phosphatidylinositol 3-Kinase and Extracellular Signal-regulated Kinases. The Journal of Biological Chemistry. 2003
  706. Protease-activated Receptor 2 in Colon Cancer:TRYPSIN-INDUCED MAPK PHOSPHORYLATION AND CELL PROLIFERATION ARE MEDIATED BY EPIDERMAL GROWTH FACTOR RECEPTOR TRANSACTIVATION. The Journal of Biological Chemistry. 2004
  707. Protease-activated Receptor 2-dependent Phosphorylation of the Tissue Factor Cytoplasmic Domain. The Journal of Biological Chemistry. 2004
  708. Protein Kinase B/AKT 1 Plays a Pivotal Role in Insulin-like Growth Factor-1 Receptor Signaling Induced 3T3-L1 Adipocyte Differentiation. The Journal of Biological Chemistry. 2004
  709. Protein Kinase B/Akt Prevents Fatty Acid-induced Apoptosis in Pancreatic %CE%B2-Cells (INS-1). The Journal of Biological Chemistry. 2002
  710. Protein Kinase C and ERK Activation Are Required for TFF- peptide-stimulated Bronchial Epithelial Cell Migration and Tumor Necrosis Factor-%CE%B1-induced Interleukin-6 (IL-6) and IL-8 Secretion. The Journal of Biological Chemistry. 2002
  711. Protein Kinase C Isoforms Involved in the Transcriptional Activation of Cyclin D1 by Transforming Ha-Ras. The Journal of Biological Chemistry. 2001
  712. Protein Kinase C%CE%B4 Regulates Keratinocyte Death and Survival by Regulating Activity and Subcellular Localization of a p38%CE%B4-Extracellular Signal-Regulated Kinase 1/2 Complex. Molecular and Cellular Biology. 2004
  713. Protein Kinase D Potentiates DNA Synthesis Induced by Gq-coupled Receptors by Increasing the Duration of ERK Signaling in Swiss 3T3 Cells. The Journal of Biological Chemistry. 2004
  714. Protein Phosphatase 2A, a Negative Regulator of the ERK Signaling Pathway, Is Activated by Tyrosine Phosphorylation of Putative HLA Class II-associated Protein I (PHAPI)/pp32 in Response to the Antiproliferative Lectin, Jacalin. The Journal of Biological Chemistry. 2004
  715. Protein Tyrosine Phosphatase Non-Receptor Type 22 Modulates NOD2-Induced Cytokine Release and Autophagy. PLoS ONE. 2013
  716. Protein Tyrosine Phosphatase-1B Modulates Pancreatic β-cell Mass. PLoS ONE. 2014
  717. Proteinase Suppression by E-cadherin-mediated Cell-Cell Attachment in Premalignant Oral Keratinocytes. The Journal of Biological Chemistry. 2002
  718. Pterostilbene Simultaneously Induced G0/G1-Phase Arrest and MAPK-Mediated Mitochondrial-Derived Apoptosis in Human Acute Myeloid Leukemia Cell Lines. PLoS ONE. 2014
  719. PTK6 Promotes Cancer Migration and Invasion in Pancreatic Cancer Cells Dependent on ERK Signaling. PLoS ONE. 2014
  720. PV1 Is a Key Structural Component for the Formation of the Stomatal and Fenestral Diaphragms. Molecular Biology of the Cell. 2004
  721. Pyk2 Amplifies Epidermal Growth Factor and c-Src-induced Stat3 Activation. The Journal of Biological Chemistry. 2004
  722. Rac Activation upon Cell-Cell Contact Formation Is Dependent on Signaling from the Epidermal Growth Factor Receptor. The Journal of Biological Chemistry. 2002
  723. RanBP9 Plays a Critical Role in Neonatal Brain Development in Mice. PLoS ONE. 2013
  724. RANKL and Vascular Endothelial Growth Factor (VEGF) Induce Osteoclast Chemotaxis through an ERK1/2-dependent Mechanism. The Journal of Biological Chemistry. 2003
  725. RANTES-mediated Chemokine Transcription in Astrocytes Involves Activation and Translocation of p90 Ribosomal S6 Protein Kinase (RSK). The Journal of Biological Chemistry. 2002
  726. Rap1 Functions as a Key Regulator of T-Cell and Antigen-Presenting Cell Interactions and Modulates T-Cell Responses. Molecular and Cellular Biology. 2002
  727. Rap1 Is Activated by Erythropoietin or Interleukin-3 and Is Involved in Regulation of %CE%B21 Integrin-mediated Hematopoietic Cell Adhesion. The Journal of Biological Chemistry. 2001
  728. Rapamycin Ameliorates Inflammation and Fibrosis in the Early Phase of Cirrhotic Portal Hypertension in Rats through Inhibition of mTORC1 but Not mTORC2. PLoS ONE. 2014
  729. Rapamycin-Insensitive Up-Regulation of Adipocyte Phospholipase A2 in Tuberous Sclerosis and Lymphangioleiomyomatosis. PLoS ONE. 2014
  730. Ras Activation in Jurkat T cells following Low-Grade Stimulation of the T-Cell Receptor Is Specific to N-Ras and Occurs Only on the Golgi Apparatus. Molecular and Cellular Biology. 2004
  731. Ras/MAPK Pathway Confers Basement Membrane Dependence upon Endoderm Differentiation of Embryonic Carcinoma Cells. The Journal of Biological Chemistry. 2002
  732. Ras-dependent ERK Activation by the Human Gs-coupled Serotonin Receptors 5-HT4(b) and 5-HT7(a). The Journal of Biological Chemistry. 2003
  733. RasGRP1 Sensitizes an Immature B Cell Line to Antigen Receptor-induced Apoptosis. The Journal of Biological Chemistry. 2004
  734. Reactive Oxygen Species Are Required for 5-HT-Induced Transactivation of Neuronal Platelet-Derived Growth Factor and TrkB Receptors, but Not for ERK1/2 Activation. PLoS ONE. 2013
  735. Reactive Oxygen Species Differentially Affect T Cell Receptor-signaling Pathways*. The Journal of Biological Chemistry. 2002
  736. Reactive Oxygen Species Sensitivity of Angiotensin II-dependent Translation Initiation in Vascular Smooth Muscle Cells. The Journal of Biological Chemistry. 2003
  737. Receptor for Advanced Glycation End Products (RAGE) Signaling Induces CREB-dependent Chromogranin Expression during Neuronal Differentiation. The Journal of Biological Chemistry. 2002
  738. Receptor-selective Effects of Endogenous RGS3 and RGS5 to Regulate Mitogen-activated Protein Kinase Activation in Rat Vascular Smooth Muscle Cells. The Journal of Biological Chemistry. 2002
  739. Reciprocal Regulation of Angiotensin Receptor-activated Extracellular Signal-regulated Kinases by %CE%B2-Arrestins 1 and 2. The Journal of Biological Chemistry. 2004
  740. Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain. The EMBO Journal. 2002
  741. Regulation of apoptosis by Bcl-2 cysteine oxidation in human lung epithelial cells. Molecular Biology of the Cell. 2013
  742. Regulation of Constitutive Neutrophil Apoptosis Due to House Dust Mite Allergen in Normal and Allergic Rhinitis Subjects. PLoS ONE. 2014
  743. Regulation of Cyclooxgenase-2 mRNA Stability by Taxanes:EVIDENCE FOR INVOLVEMENT OF p38, MAPKAPK-2, and HuR. The Journal of Biological Chemistry. 2003
  744. Regulation of Embryonic Stem Cell Self-renewal by Phosphoinositide 3-Kinase-dependent Signaling. The Journal of Biological Chemistry. 2004
  745. Regulation of Epidermal Growth Factor-induced Connexin 43 Gap Junction Communication by Big Mitogen-activated Protein Kinase 1/ERK5 but Not ERK1/2 Kinase Activation. The Journal of Biological Chemistry. 2003
  746. Regulation of ERK1 and ERK2 by Glucose and Peptide Hormones in Pancreatic %CE%B2 Cells. The Journal of Biological Chemistry. 2003
  747. Regulation of Id Gene Expression by Type I Insulin-Like Growth Factor: Roles of STAT3 and the Tyrosine 950 Residue of the Receptor. Molecular and Cellular Biology. 2001
  748. Regulation of Insulin/Insulin-like Growth Factor-1 Signaling by Proteasome-mediated Degradation of Insulin Receptor Substrate-2. The Journal of Biological Chemistry. 2001
  749. Regulation of Interleukin-1%CE%B1 Expression by Integrins and Epidermal Growth Factor Receptor in Keratinocytes from a Mouse Model of Inflammatory Skin Disease. The Journal of Biological Chemistry. 2003
  750. Regulation of Interleukin-6 Promoter Activation in Gastric Epithelial Cells Infected with Helicobacter pylori. Molecular Biology of the Cell. 2005
  751. Regulation of Lipoprotein Lipase by Protein Kinase C%CE%B1 in 3T3-F442A Adipocytes. The Journal of Biological Chemistry. 2002
  752. Regulation of NADPH Oxidase 5 by Protein Kinase C Isoforms. PLoS ONE. 2014
  753. Regulation of SPIN90 Phosphorylation and Interaction with Nck by ERK and Cell Adhesion. The Journal of Biological Chemistry. 2003
  754. Regulation of the Cell Surface Expression and Function of Angiotensin II Type 1 Receptor by Rab1-mediated Endoplasmic Reticulum-to-Golgi Transport in Cardiac Myocytes. The Journal of Biological Chemistry. 2004
  755. Regulation of Vascular Endothelial Growth Factor Binding and Activity by Extracellular pH. The Journal of Biological Chemistry. 2003
  756. Regulation of Vascular Endothelial Growth Factor Expression by Advanced Glycation End Products. The Journal of Biological Chemistry. 2001
  757. Regulator of G Protein Signaling 2 (RGS2) and RGS4 Form Distinct G Protein-Dependent Complexes with Protease Activated-Receptor 1 (PAR1) in Live Cells. PLoS ONE. 2014
  758. Regulatory Mechanism of Endothelin Receptor B in the Cerebral Arteries after Focal Cerebral Ischemia. PLoS ONE. 2014
  759. Response of Human Pulmonary Epithelial Cells to Lipopolysaccharide Involves Toll-like Receptor 4 (TLR4)-dependent Signaling Pathways:EVIDENCE FOR AN INTRACELLULAR COMPARTMENTALIZATION OF TLR4. The Journal of Biological Chemistry. 2004
  760. Response-Predictive Gene Expression Profiling of Glioma Progenitor Cells In Vitro. PLoS ONE. 2014
  761. Resveratrol and Estradiol Rapidly Activate MAPK Signaling through Estrogen Receptors %CE%B1 and %CE%B2 in Endothelial Cells. The Journal of Biological Chemistry. 2005
  762. Resveratrol as a Natural Anti-Tumor Necrosis Factor-α Molecule: Implications to Dendritic Cells and Their Crosstalk with Mesenchymal Stromal Cells. PLoS ONE. 2014
  763. Retnla Overexpression Attenuates Allergic Inflammation of the Airway. PLoS ONE. 2014
  764. Reversible Modulation of Myofibroblast Differentiation in Adipose-Derived Mesenchymal Stem Cells. PLoS ONE. 2014
  765. RGS16 Function Is Regulated by Epidermal Growth Factor Receptor-mediated Tyrosine Phosphorylation. The Journal of Biological Chemistry. 2001
  766. RhoA Inhibits the Nerve Growth Factor-induced Rac1 Activation through Rho-associated Kinase-dependent Pathway. The Journal of Biological Chemistry. 2001
  767. Ribosomal S6 Kinase (RSK) Regulates Phosphorylation of Filamin A on an Important Regulatory Site. Molecular and Cellular Biology. 2004
  768. Ribosomal S6 Kinase 2 Inhibition by a Potent C-terminal Repressor Domain Is Relieved by Mitogen-activated Protein-Extracellular Signal-regulated Kinase Kinase-regulated Phosphorylation. The Journal of Biological Chemistry. 2001
  769. Rip2 Participates in Bcl10 Signaling and T-cell Receptor-mediated NF-%CE%BAB Activation. The Journal of Biological Chemistry. 2004
  770. Roflumilast N-Oxide Prevents Cytokine Secretion Induced by Cigarette Smoke Combined with LPS through JAK/STAT and ERK1/2 Inhibition in Airway Epithelial Cells. PLoS ONE. 2014
  771. Role of Dok1 in Cell Signaling Mediated by RET Tyrosine Kinase. The Journal of Biological Chemistry. 2002
  772. Role of G Protein-coupled Receptor Kinase 4 and %CE%B2-Arrestin 1 in Agonist-stimulated Metabotropic Glutamate Receptor 1 Internalization and Activation of Mitogen-activated Protein Kinases. The Journal of Biological Chemistry. 2003
  773. Role of Hyaluronan and Reactive Oxygen Species in Tissue Kallikrein-mediated Epidermal Growth Factor Receptor Activation in Human Airways. The Journal of Biological Chemistry. 2004
  774. Role of Mitochondria in Parvovirus Pathology. PLoS ONE. 2014
  775. Role of Mitogen-activated Protein Kinases in 4-Hydroxy-2-nonenal-induced Actin Remodeling and Barrier Function in Endothelial Cells. The Journal of Biological Chemistry. 2004
  776. Role of N-Methyl-d-aspartate Receptors in the Neuroprotective Activation of Extracellular Signal-regulated Kinase 1/2 by Cisplatin. The Journal of Biological Chemistry. 2003
  777. Role of Protein Kinase C in the Signal Pathways That Link Na+/K+-ATPase to ERK1/2. The Journal of Biological Chemistry. 2001
  778. Role of Protein Tyrosine Phosphatase Non-Receptor Type 7 in the Regulation of TNF-α Production in RAW 264.7 Macrophages. PLoS ONE. 2013
  779. Role of SHP-2 in Fibroblast Growth Factor Receptor-Mediated Suppression of Myogenesis in C2C12 Myoblasts. Molecular and Cellular Biology. 2002
  780. Role of Sphingosine-1-phosphate Phosphatase 1 in Epidermal Growth Factor-induced Chemotaxis. The Journal of Biological Chemistry. 2004
  781. Role of the ERK Pathway for Oxidant-Induced Parthanatos in Human Lymphocytes. PLoS ONE. 2014
  782. Role of the p38 Mitogen-activated Protein Kinase Pathway in the Generation of the Effects of Imatinib Mesylate (STI571) in BCR-ABL-expressing Cells. The Journal of Biological Chemistry. 2004
  783. Role of the p66Shc Isoform in Insulin-like Growth Factor I Receptor Signaling through MEK/Erk and Regulation of Actin Cytoskeleton in Rat Myoblasts. The Journal of Biological Chemistry. 2004
  784. Role of Vascular Smooth Muscle PPARγ in Regulating AT1 Receptor Signaling and Angiotensin II-Dependent Hypertension. PLoS ONE. 2014
  785. Roles of Gab1 and SHP2 in Paxillin Tyrosine Dephosphorylation and Src Activation in Response to Epidermal Growth Factor. The Journal of Biological Chemistry. 2004
  786. Roles of Stem Cell Factor/c-Kit and Effects of Glivec%C2%AE/STI571 in Human Uveal Melanoma Cell Tumorigenesis. The Journal of Biological Chemistry. 2004
  787. RSK2 Activity Is Regulated by Its Interaction with PEA-15. The Journal of Biological Chemistry. 2003
  788. S6K1%E2%88%92/%E2%88%92/S6K2%E2%88%92/%E2%88%92 Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5%E2%80%B2-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway. Molecular and Cellular Biology. 2004
  789. Secreted Protein Acidic, Rich in Cysteine (SPARC), Mediates Cellular Survival of Gliomas through AKT Activation. The Journal of Biological Chemistry. 2004
  790. Secretion of Annexin II via Activation of Insulin Receptor and Insulin-like Growth Factor Receptor. The Journal of Biological Chemistry. 2003
  791. Sef Inhibits Fibroblast Growth Factor Signaling by Inhibiting FGFR1 Tyrosine Phosphorylation and Subsequent ERK Activation. The Journal of Biological Chemistry. 2003
  792. SEL1L Regulates Adhesion, Proliferation and Secretion of Insulin by Affecting Integrin Signaling. PLoS ONE. 2013
  793. Selective Cytotoxic Mechanism of GTP-14564, a Novel Tyrosine Kinase Inhibitor in Leukemia Cells Expressing a Constitutively Active Fms-like Tyrosine Kinase 3 (FLT3). The Journal of Biological Chemistry. 2003
  794. Selective Inhibition of Heterotrimeric GsSignaling:TARGETING THE RECEPTOR-G PROTEIN INTERFACE USING A PEPTIDE MINIGENE ENCODING THE G%CE%B1s CARBOXYL TERMINUS%0A. The Journal of Biological Chemistry. 2002
  795. Selenite-induced Survival of HuH7 Hepatoma Cells Involves Activation of Focal Adhesion Kinase-Phosphatidylinositol 3-Kinase-Akt Pathway and Rac1. The Journal of Biological Chemistry. 2003
  796. Sequence-Dependent Antiproliferative Effects of Gefitinib and Docetaxel on Non-Small Cell Lung Cancer (NSCLC) Cells and the Possible Mechanism. PLoS ONE. 2014
  797. Sequential Activation of Protein Kinase C (PKC)-%CE%B1 and PKC-%CE%B5 Contributes to Sustained Raf/ERK1/2 Activation in Endothelial Cells under Mechanical Strain. The Journal of Biological Chemistry. 2001
  798. Ser/Thr Protein Phosphatase 5 Inactivates Hypoxia-induced Activation of an Apoptosis Signal-regulating Kinase 1/MKK-4/JNK Signaling Cascade. The Journal of Biological Chemistry. 2004
  799. Serotonin 5-HT3 Receptor-Mediated Vomiting Occurs via the Activation of Ca2+/CaMKII-Dependent ERK1/2 Signaling in the Least Shrew (Cryptotis parva). PLoS ONE. 2014
  800. Serotonin-induced MMP-13 Production Is Mediated via Phospholipase C, Protein Kinase C, and ERK1/2 in Rat Uterine Smooth Muscle Cells. The Journal of Biological Chemistry. 2002
  801. Serum Amino Acids Profile and the Beneficial Effects of L-Arginine or L-Glutamine Supplementation in Dextran Sulfate Sodium Colitis. PLoS ONE. 2014
  802. Serum Amyloid A Induces NLRP-3-Mediated IL-1β Secretion in Neutrophils. PLoS ONE. 2014
  803. Shear stress activates extracellular signal-regulated kinase 1/2 via the angiotensin II type 1 receptor. The FASEB Journal. 2013
  804. Shear Stress Stimulates Phosphorylation of Endothelial Nitric-oxide Synthase at Ser1179 by Akt-independent Mechanisms:ROLE OF PROTEIN KINASE A. The Journal of Biological Chemistry. 2002
  805. Shikonins, Phytocompounds from Lithospermum erythrorhizon, Inhibit the Transcriptional Activation of Human Tumor Necrosis Factor %CE%B1 Promoter in Vivo. The Journal of Biological Chemistry. 2004
  806. Sialidase NEU3 Dynamically Associates to Different Membrane Domains Specifically Modifying Their Ganglioside Pattern and Triggering Akt Phosphorylation. PLoS ONE. 2014
  807. Signal Transduction Pathways Involved in Rheumatoid Arthritis Synovial Fibroblast Interleukin-18-induced Vascular Cell Adhesion Molecule-1 Expression. The Journal of Biological Chemistry. 2002
  808. Signaling Events in Amyloid %CE%B2-Peptide-induced Neuronal Death and Insulin-like Growth Factor I Protection. The Journal of Biological Chemistry. 2002
  809. Signaling through Extracellular Signal-regulated Kinase Is Required for Spermatogonial Proliferative Response to Stem Cell Factor. The Journal of Biological Chemistry. 2001
  810. Signalling-Dependent Adverse Health Effects of Carbon Nanoparticles Are Prevented by the Compatible Solute Mannosylglycerate (Firoin) In Vitro and In Vivo. PLoS ONE. 2014
  811. Silibinin Up-regulates DNA-Protein Kinase-dependent p53 Activation to Enhance UVB-induced Apoptosis in Mouse Epithelial JB6 Cells. The Journal of Biological Chemistry. 2005
  812. Simultaneous Inhibition of the HGF/MET and Erk1/2 Pathways Affect Uveal Melanoma Cell Growth and Migration. PLoS ONE. 2014
  813. Sirt1 Deletion Leads to Enhanced Inflammation and Aggravates Endotoxin-Induced Acute Kidney Injury. PLoS ONE. 2014
  814. Site-Selective Regulation of Platelet-Derived Growth Factor %CE%B2 Receptor Tyrosine Phosphorylation by T-Cell Protein Tyrosine Phosphatase. Molecular and Cellular Biology. 2004
  815. SKIP Negatively Regulates Insulin-Induced GLUT4 Translocation and Membrane Ruffle Formation. Molecular and Cellular Biology. 2003
  816. SLCO3A1, a Novel Crohn’s Disease-Associated Gene, Regulates NF-κB Activity and Associates with Intestinal Perforation. PLoS ONE. 2014
  817. Smad3 Mediates Transforming Growth Factor-%CE%B2-induced Collagenase-3 (Matrix Metalloproteinase-13) Expression in Human Gingival Fibroblasts:EVIDENCE FOR CROSS-TALK BETWEEN Smad3 AND p38 SIGNALING PATHWAYS. The Journal of Biological Chemistry. 2002
  818. Small Interfering RNA-mediated Down-regulation of Caveolin-1 Differentially Modulates Signaling Pathways in Endothelial Cells. The Journal of Biological Chemistry. 2004
  819. SmgGDS antagonizes BPGAP1-induced Ras/ERK activation and neuritogenesis in PC12 cell differentiation. Molecular Biology of the Cell. 2013
  820. Smooth Muscle Actin Determines Mechanical Force-induced p38 Activation. The Journal of Biological Chemistry. 2005
  821. Snail Family Members Unequally Trigger EMT and Thereby Differ in Their Ability to Promote the Neoplastic Transformation of Mammary Epithelial Cells. PLoS ONE. 2014
  822. SOCS3 Is a Physiological Negative Regulator for Granulopoiesis and Granulocyte Colony-stimulating Factor Receptor Signaling. The Journal of Biological Chemistry. 2004
  823. Sodium Ferulate Inhibits Neointimal Hyperplasia in Rat Balloon Injury Model. PLoS ONE. 2014
  824. Soluble Urokinase-type Plasminogen Activator Receptor Inhibits Cancer Cell Growth and Invasion by Direct Urokinase-independent Effects on Cell Signaling. The Journal of Biological Chemistry. 2003
  825. SOX2 Enhances the Migration and Invasion of Ovarian Cancer Cells via Src Kinase. PLoS ONE. 2014
  826. Sphingosine 1-Phosphate (S1P) Receptor Subtypes S1P1 and S1P3, Respectively, Regulate Lymphocyte Recirculation and Heart Rate. The Journal of Biological Chemistry. 2004
  827. Sphingosine 1-Phosphate and Isoform-specific Activation of Phosphoinositide 3-Kinase %CE%B2:EVIDENCE FOR DIVERGENCE AND CONVERGENCE OF RECEPTOR-REGULATED ENDOTHELIAL NITRIC-OXIDE SYNTHASE SIGNALING PATHWAYS. The Journal of Biological Chemistry. 2001
  828. Sphingosine 1-Phosphate Cross-activates the Smad Signaling Cascade and Mimics Transforming Growth Factor-%CE%B2-induced Cell Responses. The Journal of Biological Chemistry. 2004
  829. Sphingosine 1-Phosphate May Be a Major Component of Plasma Lipoproteins Responsible for the Cytoprotective Actions in Human Umbilical Vein Endothelial Cells. The Journal of Biological Chemistry. 2001
  830. Sphingosine 1-Phosphate Receptors Are Essential Mediators of Eyelid Closure during Embryonic Development. The Journal of Biological Chemistry. 2013
  831. Sphingosine Kinase Mediates Vascular Endothelial Growth Factor-Induced Activation of Ras and Mitogen-Activated Protein Kinases. Molecular and Cellular Biology. 2002
  832. Sphingosine Kinase Protects Lipopolysaccharide-Activated Macrophages from Apoptosis. Molecular and Cellular Biology. 2004
  833. Sphingosylphosphorylcholine and Lysophosphatidylcholine Are Ligands for the G Protein-coupled Receptor GPR4. The Journal of Biological Chemistry. 2001
  834. Spred-2 Deficiency Exacerbates Lipopolysaccharide-Induced Acute Lung Inflammation in Mice. PLoS ONE. 2014
  835. Src Homology 3 Binding Sites in the P2Y2 Nucleotide Receptor Interact with Src and Regulate Activities of Src, Proline-rich Tyrosine Kinase 2, and Growth Factor Receptors. The Journal of Biological Chemistry. 2004
  836. Src Is Required for Mechanical Stretch-Induced Cardiomyocyte Hypertrophy through Angiotensin II Type 1 Receptor-Dependent β-Arrestin2 Pathways. PLoS ONE. 2014
  837. Src-mediated RGS16 Tyrosine Phosphorylation Promotes RGS16 Stability. The Journal of Biological Chemistry. 2003
  838. sst2 Somatostatin Receptor Inhibits Cell Proliferation through Ras-, Rap1-, and B-Raf-dependent ERK2 Activation. The Journal of Biological Chemistry. 2003
  839. Stability of the Endosomal Scaffold Protein LAMTOR3 Depends on Heterodimer Assembly and Proteasomal Degradation. The Journal of Biological Chemistry. 2013
  840. Stabilization of Tumor Necrosis Factor %CE%B1 mRNA by Chronic Ethanol:ROLE OF A + U-RICH ELEMENTS AND p38 MITOGEN-ACTIVATED PROTEIN KINASE SIGNALING PATHWAY. The Journal of Biological Chemistry. 2001
  841. Stable Interaction between %CE%B2-Arrestin 2 and Angiotensin Type 1A Receptor Is Required for %CE%B2-Arrestin 2-mediated Activation of Extracellular Signal-regulated Kinases 1 and 2. The Journal of Biological Chemistry. 2004
  842. STAT5 and Prolactin Participate in a Positive Autocrine Feedback Loop That Promotes Angiogenesis. The Journal of Biological Chemistry. 2013
  843. Stathmin Mediates Hepatocyte Resistance to Death from Oxidative Stress by down Regulating JNK. PLoS ONE. 2014
  844. Static Mechanical Stress Induces Apoptosis in Rat Endplate Chondrocytes through MAPK and Mitochondria-Dependent Caspase Activation Signaling Pathways. PLoS ONE. 2013
  845. Staurosporine and Extracellular Matrix Proteins Mediate the Conversion of Small Cell Lung Carcinoma Cells into a Neuron-Like Phenotype. PLoS ONE. 2014
  846. Stem Cell Factor/c-kit Signaling Promotes the Survival, Migration, and Capillary Tube Formation of Human Umbilical Vein Endothelial Cells. The Journal of Biological Chemistry. 2004
  847. Stimulation of Cellular Signaling and G Protein Subunit Dissociation by G Protein %CE%B2%CE%B3 Subunit-binding Peptides. The Journal of Biological Chemistry. 2003
  848. Stimulation of Extracellular Signal-regulated Kinases and Proliferation in Rat Osteoblastic Cells by Parathyroid Hormone Is Protein Kinase C-dependent. The Journal of Biological Chemistry. 2001
  849. Stimulation of Lipolysis and Hormone-sensitive Lipase via the Extracellular Signal-regulated Kinase Pathway. The Journal of Biological Chemistry. 2001
  850. Stimulation of Proliferation of Rat Hepatic Stellate Cells by Galectin-1 and Galectin-3 through Different Intracellular Signaling Pathways. The Journal of Biological Chemistry. 2003
  851. Stress-induced Inhibition of ERK1 and ERK2 by Direct Interaction with p38 MAP Kinase. The Journal of Biological Chemistry. 2001
  852. Stretch-induced Retinal Vascular Endothelial Growth Factor Expression Is Mediated by Phosphatidylinositol 3-Kinase and Protein Kinase C (PKC)-%CE%B6 but Not by Stretch-induced ERK1/2, Akt, Ras, or Classical/Novel PKC Pathways. The Journal of Biological Chemistry. 2002
  853. Structural Requirements of SLP-76 in Signaling via the High-Affinity Immunoglobulin E Receptor (Fc%CE%B5RI) in Mast Cells. Molecular and Cellular Biology. 2003
  854. SU1498, an Inhibitor of Vascular Endothelial Growth Factor Receptor 2, Causes Accumulation of Phosphorylated ERK Kinases and Inhibits Their Activity in Vivo and in Vitro. The Journal of Biological Chemistry. 2004
  855. Subcellular Localization Determines the Protective Effects of Activated ERK2 against Distinct Apoptogenic Stimuli in Myeloid Leukemia Cells. The Journal of Biological Chemistry. 2004
  856. Subdomain X of the Kinase Domain of Lck Binds CD45 and Facilitates Dephosphorylation. The Journal of Biological Chemistry. 2004
  857. Sulforaphane Inhibits Invasion via Activating ERK1/2 Signaling in Human Glioblastoma U87MG and U373MG Cells. PLoS ONE. 2014
  858. Superoxide Mediates Direct Current Electric Field-Induced Directional Migration of Glioma Cells through the Activation of AKT and ERK. PLoS ONE. 2013
  859. Suppression of Apoptosis Induced by Growth Factor Withdrawal by an Oncogenic Form of c-Cbl. The Journal of Biological Chemistry. 2001
  860. Suppression of Extracellular Signal-related Kinase and Activation of p38 MAPK Are Two Critical Events Leading to Caspase-8- and Mitochondria-mediated Cell Death in Phytosphingosine-treated Human Cancer Cells. The Journal of Biological Chemistry. 2003
  861. Suppression of Integrin Activation by Activated Ras or Raf Does Not Correlate with Bulk Activation of ERK MAP Kinase. Molecular Biology of the Cell. 2002
  862. Suppressors of Cytokine Signaling-1 and -6 Associate with and Inhibit the Insulin Receptor:A POTENTIAL MECHANISM FOR CYTOKINE-MEDIATED INSULIN RESISTANCE. The Journal of Biological Chemistry. 2001
  863. Sutherlandia frutescens Ethanol Extracts Inhibit Oxidative Stress and Inflammatory Responses in Neurons and Microglial Cells. PLoS ONE. 2014
  864. Synergistic Apoptosis of CML Cells by Buthionine Sulfoximine and Hydroxychavicol Correlates with Activation of AIF and GSH-ROS-JNK-ERK-iNOS Pathway. PLoS ONE. 2013
  865. Synergistic Growth of Stem Cell Factor and Granulocyte Macrophage Colony-stimulating Factor Involves Kinase-dependent and -independent Contributions from c-Kit. The Journal of Biological Chemistry. 2004
  866. Systemic Sclerosis Immunoglobulin Induces Growth and a Pro-Fibrotic State in Vascular Smooth Muscle Cells through the Epidermal Growth Factor Receptor. PLoS ONE. 2014
  867. Targeted Inhibition of p38 Mitogen-activated Protein Kinase Antagonizes Cardiac Injury and Cell Death Following Ischemia-Reperfusion in Vivo. The Journal of Biological Chemistry. 2004
  868. Targeting Oncoprotein Stability Overcomes Drug Resistance Caused by FLT3 Kinase Domain Mutations. PLoS ONE. 2014
  869. TCDD Promotes Lung Tumors via Attenuation of Apoptosis through Activation of the Akt and ERK1/2 Signaling Pathways. PLoS ONE. 2014
  870. TDAG51 Mediates the Effects of Insulin-like Growth Factor I (IGF-I) on Cell Survival. The Journal of Biological Chemistry. 2004
  871. Ten ERK-related Proteins in Three Distinct Classes Associate with AP-1 Proteins and/or AP-1 DNA. The Journal of Biological Chemistry. 2001
  872. Testosterone Is Responsible for Enhanced Susceptibility of Males to Ischemic Renal Injury. The Journal of Biological Chemistry. 2004
  873. Tetramethylpyrazine Suppresses Transient Oxygen-Glucose Deprivation-Induced Connexin32 Expression and Cell Apoptosis via the ERK1/2 and p38 MAPK Pathway in Cultured Hippocampal Neurons. PLoS ONE. 2014
  874. The Activation of Rac1 by M3 Muscarinic Acetylcholine Receptors Involves the Translocation of Rac1 and IQGAP1 to Cell Junctions and Changes in the Composition of Protein Complexes Containing Rac1, IQGAP1, and Actin. The Journal of Biological Chemistry. 2002
  875. The AMPK Agonist AICAR Inhibits TGF-β1 Induced Activation of Kidney Myofibroblasts. PLoS ONE. 2014
  876. The Angiotensin II Type 1 Receptor C-Terminal Lys Residues Interact with Tubulin and Modulate Receptor Export Trafficking. PLoS ONE. 2013
  877. The Anti-Apoptotic and Cardioprotective Effects of Salvianolic Acid A on Rat Cardiomyocytes following Ischemia/Reperfusion by DUSP-Mediated Regulation of the ERK1/2/JNK Pathway. PLoS ONE. 2014
  878. The Apoptotic Regulatory Protein ARC (Apoptosis Repressor with Caspase Recruitment Domain) Prevents Oxidant Stress-mediated Cell Death by Preserving Mitochondrial Function. The Journal of Biological Chemistry. 2001
  879. The Bcr Kinase Downregulates Ras Signaling by Phosphorylating AF-6 and Binding to Its PDZ Domain. Molecular and Cellular Biology. 2003
  880. The Binding of Monomeric C-Reactive Protein (mCRP) to Integrins αvβ3 and α4β1 Is Related to Its Pro-Inflammatory Action. PLoS ONE. 2014
  881. The Bone-specific Transcriptional Regulator Cbfa1 Is a Target of Mechanical Signals in Osteoblastic Cells. The Journal of Biological Chemistry. 2002
  882. The Catalytic Subunit of Protein Phosphatase 2A (PP2Ac) Promotes DNA Hypomethylation by Suppressing the Phosphorylated Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (ERK) Kinase (MEK)/Phosphorylated ERK/DNMT1 Protein Pathway in T-cells from Controls and Systemic Lupus Erythematosus Patients. The Journal of Biological Chemistry. 2013
  883. The c-Jun N-terminal Kinase 1 Activity Is Differentially Regulated by Specific Mechanisms during Apoptosis. The Journal of Biological Chemistry. 2003
  884. The Complex Interplay between ERK1/2, TGFβ/Smad, and Jagged/Notch Signaling Pathways in the Regulation of Epithelial-Mesenchymal Transition in Retinal Pigment Epithelium Cells. PLoS ONE. 2014
  885. The Dual RAF/MEK Inhibitor CH5126766/RO5126766 May Be a Potential Therapy for RAS-Mutated Tumor Cells. PLoS ONE. 2014
  886. The Endoplasmic Reticulum-resident Heat Shock Protein Gp96 Activates Dendritic Cells via the Toll-like Receptor 2/4 Pathway. The Journal of Biological Chemistry. 2002
  887. The ERK Signaling Cascade Inhibits Gonadotropin-stimulated Steroidogenesis. The Journal of Biological Chemistry. 2001
  888. The Extraction of Simple Relationships in Growth Factor-Specific Multiple-Input and Multiple-Output Systems in Cell-Fate Decisions by Backward Elimination PLS Regression. PLoS ONE. 2013
  889. The Hepatitis E Virus Open Reading Frame 3 Protein Activates ERK through Binding and Inhibition of the MAPK Phosphatase. The Journal of Biological Chemistry. 2004
  890. The Herbicide Paraquat Induces Dopaminergic Nigral Apoptosis through Sustained Activation of the JNK Pathway. The Journal of Biological Chemistry. 2004
  891. The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR. The EMBO Journal. 2001
  892. The Human Estrogen Receptor-%CE%B1 Is a Ubiquitinated Protein Whose Stability Is Affected Differentially by Agonists, Antagonists, and Selective Estrogen Receptor Modulators. The Journal of Biological Chemistry. 2001
  893. The Induction of Prostaglandin E2 Production, Interleukin-6 Production, Cell Cycle Arrest, and Cytotoxicity in Primary Oral Keratinocytes and KB Cancer Cells by Areca Nut Ingredients Is Differentially Regulated by MEK/ERK Activation. The Journal of Biological Chemistry. 2004
  894. The Inhibition of N-Glycosylation of Glycoprotein 130 Molecule Abolishes STAT3 Activation by IL-6 Family Cytokines in Cultured Cardiac Myocytes. PLoS ONE. 2014
  895. The Interactions of Hepatocyte Growth Factor/Scatter Factor and Its NK1 and NK2 Variants with Glycosaminoglycans Using a Modified Gel Mobility Shift Assay:ELUCIDATION OF THE MINIMAL SIZE OF BINDING AND ACTIVATORY OLIGOSACCHARIDES. The Journal of Biological Chemistry. 2004
  896. The Interferon Consensus Sequence-binding Protein Activates Transcription of the Gene Encoding Neurofibromin 1. The Journal of Biological Chemistry. 2004
  897. The KDEL Receptor Modulates the Endoplasmic Reticulum Stress Response through Mitogen-activated Protein Kinase Signaling Cascades. The Journal of Biological Chemistry. 2003
  898. The Lck SH3 Domain Negatively Regulates Localization to Lipid Rafts through an Interaction with c-Cbl. The Journal of Biological Chemistry. 2002
  899. The LIM-Only Protein FHL2 Reduces Vascular Lesion Formation Involving Inhibition of Proliferation and Migration of Smooth Muscle Cells. PLoS ONE. 2014
  900. The M1 Receptor Is Required for Muscarinic Activation of Mitogen-activated Protein (MAP) Kinase in Murine Cerebral Cortical Neurons. The Journal of Biological Chemistry. 2001
  901. The Mammalian Target of Rapamycin-p70 Ribosomal S6 Kinase but Not Phosphatidylinositol 3-Kinase-Akt Signaling Is Responsible for Fibroblast Growth Factor-9-induced Cell Proliferation. The Journal of Biological Chemistry. 2005
  902. The Mechanism of Intralipid?-Mediated Cardioprotection Complex IV Inhibition by the Active Metabolite, Palmitoylcarnitine, Generates Reactive Oxygen Species and Activates Reperfusion Injury Salvage Kinases. PLoS ONE. 2014
  903. The MEK/ERK Pathway Promotes NOTCH Signalling in Pancreatic Cancer Cells. PLoS ONE. 2013
  904. The MEK-ERK Signaling Pathway Is a Negative Regulator of Cartilage-specific Gene Expression in Embryonic Limb Mesenchyme. The Journal of Biological Chemistry. 2004
  905. The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54. The Journal of Biological Chemistry. 2001
  906. The Mitogenic Action of Insulin-like Growth Factor I in Normal Human Mammary Epithelial Cells Requires the Epidermal Growth Factor Receptor Tyrosine Kinase. The Journal of Biological Chemistry. 2004
  907. The Mode of Action of Heparan and Dermatan Sulfates in the Regulation of Hepatocyte Growth Factor/Scatter Factor. The Journal of Biological Chemistry. 2002
  908. The Molecular Phenotype of Heparan Sulfate in theHs2st %E2%88%92/%E2%88%92 Mutant Mouse. The Journal of Biological Chemistry. 2001
  909. The Molecular Scaffold KSR1 Regulates the Proliferative and Oncogenic Potential of Cells. Molecular and Cellular Biology. 2004
  910. The mTOR Pathway Controls Cell Proliferation by Regulating the FoxO3a Transcription Factor via SGK1 Kinase. PLoS ONE. 2014
  911. The Neurofibromatosis Type 1 Gene Product Neurofibromin Enhances Cell Motility by Regulating Actin Filament Dynamics via the Rho-ROCK-LIMK2-Cofilin Pathway. The Journal of Biological Chemistry. 2005
  912. The Neuropeptide Galanin Augments Lobuloalveolar Development. The Journal of Biological Chemistry. 2003
  913. The NK1 Receptor Localizes to the Plasma Membrane Microdomains, and Its Activation Is Dependent on Lipid Raft Integrity. The Journal of Biological Chemistry. 2005
  914. The ORF3 Protein of Hepatitis E Virus Binds to Src Homology 3 Domains and Activates MAPK. The Journal of Biological Chemistry. 2001
  915. The P34G Mutation Reduces the Transforming Activity of K-Ras and N-Ras in NIH 3T3 Cells but Not of H-Ras. The Journal of Biological Chemistry. 2004
  916. The p38 MAPK Pathway Mediates Transcriptional Activation of the Plasma Platelet-activating Factor Acetylhydrolase Gene in Macrophages Stimulated with Lipopolysaccharide. The Journal of Biological Chemistry. 2004
  917. The p90 Ribosomal S6 Kinase (RSK) Is a Mediator of Smooth Muscle Contractility. PLoS ONE. 2013
  918. The Paired Activation of the Two Components of the Muscarinic M3 Receptor Dimer Is Required for Induction of ERK1/2 Phosphorylation. The Journal of Biological Chemistry. 2004
  919. The Pancreas Is Altered by In Utero Androgen Exposure: Implications for Clinical Conditions Such as Polycystic Ovary Syndrome (PCOS). PLoS ONE. 2013
  920. The Pentachlorophenol Metabolite Tetrachlorohydroquinone Induces Massive ROS and Prolonged p-ERK Expression in Splenocytes, Leading to Inhibition of Apoptosis and Necrotic Cell Death. PLoS ONE. 2014
  921. The Potentiation Role of Hepatopoietin on Activator Protein-1 Is Dependent on Its Sulfhydryl Oxidase Activity. The Journal of Biological Chemistry. 2003
  922. The Pro-atherogenic Cytokine Interleukin-18 Induces CXCL16 Expression in Rat Aortic Smooth Muscle Cells via MyD88, Interleukin-1 Receptor-associated Kinase, Tumor Necrosis Factor Receptor-associated Factor 6, c-Src, Phosphatidylinositol 3-Kinase, Akt, c-Jun N-terminal Kinase, and Activator Protein-1 Signaling. The Journal of Biological Chemistry. 2005
  923. The Protein Tyrosine Phosphatase SHP-2 Regulates Interleukin-1-induced ERK Activation in Fibroblasts. The Journal of Biological Chemistry. 2003
  924. The RasGAP N-terminal Fragment Generated by Caspase Cleavage Protects Cells in a Ras/PI3K/Akt-dependent Manner That Does Not Rely on NF%CE%BAB Activation. The Journal of Biological Chemistry. 2002
  925. The rasGAP-binding protein, Dok-1, mediates activin signaling via serine/threonine kinase receptors. The EMBO Journal. 2002
  926. The Regulation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced Lung Tumor Promotion by Estradiol in Female A/J Mice. PLoS ONE. 2014
  927. The Regulation of Uncoupling Protein-2 Gene Expression by %CF%89-6 Polyunsaturated Fatty Acids in Human Skeletal Muscle Cells Involves Multiple Pathways, Including the Nuclear Receptor Peroxisome Proliferator-activated Receptor %CE%B2. The Journal of Biological Chemistry. 2001
  928. The Relative Expression of Mig6 and EGFR Is Associated with Resistance to EGFR Kinase Inhibitors. PLoS ONE. 2013
  929. The Requirement of Specific Membrane Domains for Raf-1 Phosphorylation and Activation. The Journal of Biological Chemistry. 2003
  930. The Ribosomal S6 Kinases, cAMP-responsive Element-binding, and STAT3 Proteins Are Regulated by Different Leukemia Inhibitory Factor Signaling Pathways in Mouse Embryonic Stem Cells. The Journal of Biological Chemistry. 2001
  931. The Significance of Notch1 Compared with Notch3 in High Metastasis and Poor Overall Survival in Hepatocellular Carcinoma. PLoS ONE. 2013
  932. The Small GTPase Rap1 Is Activated by Turbulence and Is Involved in Integrin %CE%B1IIb%CE%B23-mediated Cell Adhesion in Human Megakaryocytes. The Journal of Biological Chemistry. 2003
  933. The Src Family Kinase Yes Triggers Hyperosmotic Activation of the Epidermal Growth Factor Receptor and CD95. The Journal of Biological Chemistry. 2004
  934. The Src Family of Tyrosine Kinases Is Important for Embryonic Stem Cell Self-renewal. The Journal of Biological Chemistry. 2004
  935. The Src Kinase p56 lck Up-regulates VLA-4 Integrin Affinity:IMPLICATIONS FOR RAPID SPONTANEOUS AND CHEMOKINE-TRIGGERED T CELL ADHESION TO VCAM-1 AND FIBRONECTIN. The Journal of Biological Chemistry. 2001
  936. The Stability of the G Protein-coupled Receptor-%CE%B2-Arrestin Interaction Determines the Mechanism and Functional Consequence of ERK Activation. The Journal of Biological Chemistry. 2003
  937. The STE20 Kinase HGK Is Broadly Expressed in Human Tumor Cells and Can Modulate Cellular Transformation, Invasion, and Adhesion. Molecular and Cellular Biology. 2003
  938. The Stress-activated Protein Kinases p38%CE%B1 and JNK1 Stabilize p21Cip1 by Phosphorylation. The Journal of Biological Chemistry. 2002
  939. The Therapeutic Potential and Mechanisms of Action of Quercetin in Relation to Lipopolysaccharide-Induced Sepsis In Vitro and In Vivo. PLoS ONE. 2013
  940. The Transcription Factor GATA4 Is Activated by Extracellular Signal-Regulated Kinase 1- and 2-Mediated Phosphorylation of Serine 105 in Cardiomyocytes. Molecular and Cellular Biology. 2001
  941. The Transcription Factor SOX9 Regulates Cell Cycle and Differentiation Genes in Chondrocytic CFK2 Cells. The Journal of Biological Chemistry. 2001
  942. The UV (Ribotoxic) Stress Response of Human Keratinocytes Involves the Unexpected Uncoupling of the Ras-Extracellular Signal-Regulated Kinase Signaling Cascade from the Activated Epidermal Growth Factor Receptor. Molecular and Cellular Biology. 2002
  943. The Y-box-binding Protein, YB1, Is a Potential Negative Regulator of the p53 Tumor Suppressor. The Journal of Biological Chemistry. 2003
  944. Thrombopoietin-Mediated Sustained Activation of Extracellular Signal-Regulated Kinase in UT7-Mpl Cells Requires Both Ras%E2%80%93Raf-1- and Rap1%E2%80%93B-Raf-Dependent Pathways. Molecular and Cellular Biology. 2001
  945. Thrombospondin Stimulates Focal Adhesion Disassembly through Gi- and Phosphoinositide 3-Kinase-dependent ERK Activation. The Journal of Biological Chemistry. 2002
  946. Time-Dependent Effects of Training on Cardiovascular Control in Spontaneously Hypertensive Rats: Role for Brain Oxidative Stress and Inflammation and Baroreflex Sensitivity. PLoS ONE. 2014
  947. TIMP-1 Promotes Accumulation of Cancer Associated Fibroblasts and Cancer Progression. PLoS ONE. 2013
  948. TLR2, TLR4 and CD14 Recognize Venom-Associated Molecular Patterns from Tityus serrulatus to Induce Macrophage-Derived Inflammatory Mediators. PLoS ONE. 2014
  949. Tobacco-specific Nitrosamine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Induces Phosphorylation of %CE%BC- and m-Calpain in Association with Increased Secretion, Cell Migration, and Invasion. The Journal of Biological Chemistry. 2004
  950. Tobacco-specific Nitrosamine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Promotes Functional Cooperation of Bcl2 and c-Myc through Phosphorylation in Regulating Cell Survival and Proliferation. The Journal of Biological Chemistry. 2004
  951. Toll-Like Receptor 4 Mediates Inflammatory Cytokine Secretion in Smooth Muscle Cells Induced by Oxidized Low-Density Lipoprotein. PLoS ONE. 2014
  952. Toll-Like Receptor 9 Deficiency Protects Mice against Pseudomonas aeruginosa Lung Infection. PLoS ONE. 2014
  953. Transactivation of ErbB2 and ErbB3 by Tumor Necrosis Factor-%CE%B1 and Anisomycin Leads to Impaired Insulin Signaling through Serine/Threonine Phosphorylation of IRS Proteins. The Journal of Biological Chemistry. 2002
  954. Transcription Factor AP-2%CE%B1 Is Preferentially Cleaved by Caspase 6 and Degraded by Proteasome during Tumor Necrosis Factor Alpha-Induced Apoptosis in Breast Cancer Cells. Molecular and Cellular Biology. 2001
  955. Transcriptional Induction of FosB/%CE%94FosB Gene by Mechanical Stress in Osteoblasts. The Journal of Biological Chemistry. 2004
  956. Transcriptional Regulation of APOBEC3G, a Cytidine Deaminase That Hypermutates Human Immunodeficiency Virus. The Journal of Biological Chemistry. 2004
  957. Transduction of Cell Survival Signals by Connexin-43 Hemichannels. The Journal of Biological Chemistry. 2002
  958. Transformation by Oncogenic RAS Sensitizes Human Colon Cells to TRAIL-induced Apoptosis by Up-regulating Death Receptor 4 and Death Receptor 5 through a MEK-dependent Pathway. The Journal of Biological Chemistry. 2005
  959. Transforming Growth Factor %CE%B21 (TGF-%CE%B21) Promotes Endothelial Cell Survival during In Vitro Angiogenesis via an Autocrine Mechanism Implicating TGF-%CE%B1 Signaling. Molecular and Cellular Biology. 2001
  960. Transforming Growth Factor %CE%B2-1 Induces Snail Transcription Factor in Epithelial Cell Lines:MECHANISMS FOR EPITHELIAL MESENCHYMAL TRANSITIONS. The Journal of Biological Chemistry. 2003
  961. Transforming Growth Factor %CE%B21 Is Up-regulated by Activated Raf in Skeletal Myoblasts but Does Not Contribute to the Differentiation-defective Phenotype. The Journal of Biological Chemistry. 2004
  962. Transforming Growth Factor-%CE%B1 Attenuates N-Methyl-D-aspartic Acid Toxicity in Cortical Cultures by Preventing Protein Synthesis Inhibition through an Erk1/2-dependent Mechanism. The Journal of Biological Chemistry. 2003
  963. Transforming Growth Factor-%CE%B2 (TGF-%CE%B2) Activates Cytosolic Phospholipase A2%CE%B1 (cPLA2%CE%B1)-mediated Prostaglandin E2 (PGE)2/EP1 and Peroxisome Proliferator-activated Receptor-%CE%B3 (PPAR-%CE%B3)/Smad Signaling Pathways in Human Liver Cancer Cells:A NOVEL MECHANISM FOR SUBVERSION OF TGF-%CE%B2-INDUCED MITOINHIBITION. The Journal of Biological Chemistry. 2004
  964. Transforming Growth Factor-%CE%B21 (TGF-%CE%B21)-stimulated Fibroblast to Myofibroblast Differentiation Is Mediated by Hyaluronan (HA)-facilitated Epidermal Growth Factor Receptor (EGFR) and CD44 Co-localization in Lipid Rafts. The Journal of Biological Chemistry. 2013
  965. Transforming Growth Factor-%CE%B21 Potentiates Renal Tubular Epithelial Cell Death by a Mechanism Independent of Smad Signaling. The Journal of Biological Chemistry. 2003
  966. Transforming Growth Factor-%CE%B21 Produced by Ovarian Cancer Cell Line HRA Stimulates Attachment and Invasion through an Up-regulation of Plasminogen Activator Inhibitor Type-1 in Human Peritoneal Mesothelial Cells. The Journal of Biological Chemistry. 2003
  967. Transforming Growth Factor-%CE%B2-mediated Chondrogenesis of Human Mesenchymal Progenitor Cells Involves N-cadherin and Mitogen-activated Protein Kinase and Wnt Signaling Cross-talk. The Journal of Biological Chemistry. 2003
  968. Transgenic Overexpression of Protein-tyrosine Phosphatase 1B in Muscle Causes Insulin Resistance, but Overexpression with Leukocyte Antigen-related Phosphatase Does Not Additively Impair Insulin Action. The Journal of Biological Chemistry. 2004
  969. Transitional Type 1 and 2 B Lymphocyte Subsets Are Differentially Responsive to Antigen Receptor Signaling. The Journal of Biological Chemistry. 2002
  970. Translational Control of Putative Protooncogene Nm23-M2 by Cytokines via Phosphoinositide 3-Kinase Signaling. The Journal of Biological Chemistry. 2004
  971. Transmembrane Collagen XVII Modulates Integrin Dependent Keratinocyte Migration via PI3K/Rac1 Signaling. PLoS ONE. 2014
  972. Transmembrane Peptides as Inhibitors of ErbB Receptor Signaling. Molecular Biology of the Cell. 2004
  973. Trehalose Reverses Cell Malfunction in Fibroblasts from Normal and Huntington’s Disease Patients Caused by Proteosome Inhibition. PLoS ONE. 2014
  974. Trihydrophobin 1 Is a New Negative Regulator of A-Raf Kinase. The Journal of Biological Chemistry. 2004
  975. Troglitazone, a Peroxisome Proliferator-activated Receptor %CE%B3 (PPAR%CE%B3) Ligand, Selectively Induces the Early Growth Response-1 Gene Independently of PPAR%CE%B3:A NOVEL MECHANISM FOR ITS ANTI-TUMORIGENIC ACTIVITY. The Journal of Biological Chemistry. 2003
  976. Trophic Factor Withdrawal: p38 Mitogen-Activated Protein Kinase Activates NHE1, Which Induces Intracellular Alkalinization. Molecular and Cellular Biology. 2001
  977. Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Death-inducing Signaling Complex and Its Modulation by c-FLIP and PED/PEA-15 in Glioma Cells. The Journal of Biological Chemistry. 2002
  978. Twist1- and Twist2-Haploinsufficiency Results in Reduced Bone Formation. PLoS ONE. 2014
  979. Tyrosine Kinase, p56lck-induced Cell Motility, and Urokinase-type Plasminogen Activator Secretion Involve Activation of Epidermal Growth Factor Receptor/Extracellular Signal Regulated Kinase Pathways. The Journal of Biological Chemistry. 2004
  980. Tyrosine Phosphorylation of Sprouty2 Enhances Its Interaction with c-Cbl and Is Crucial for Its Function. The Journal of Biological Chemistry. 2003
  981. Ubiquitin Carboxyl Terminal Hydrolyase L1 -Suppressed Autophagic Degradation of p21WAF1/Cip1 as a Novel Feedback Mechanism in the Control of Cardiac Fibroblast Proliferation. PLoS ONE. 2014
  982. Upregulation of Cleavage and Polyadenylation Specific Factor 4 in Lung Adenocarcinoma and Its Critical Role for Cancer Cell Survival and Proliferation. PLoS ONE. 2013
  983. Upregulation of Endocan by Epstein-Barr Virus Latent Membrane Protein 1 and Its Clinical Significance in Nasopharyngeal Carcinoma. PLoS ONE. 2013
  984. Upregulation of ERK1/2-eNOS via AT2 Receptors Decreases the Contractile Response to Angiotensin II in Resistance Mesenteric Arteries from Obese Rats. PLoS ONE. 2014
  985. Up-regulation of Vascular Endothelial Growth Factor C in Breast Cancer Cells by Heregulin-%CE%B21:A CRITICAL ROLE OF p38/NUCLEAR FACTOR-%CE%BAB SIGNALING PATHWAY. The Journal of Biological Chemistry. 2003
  986. Uridine 5′-Triphosphate Promotes In Vitro Schwannoma Cell Migration through Matrix Metalloproteinase-2 Activation. PLoS ONE. 2014
  987. Utility of a Histone Deacetylase Inhibitor (PXD101) for Thyroid Cancer Treatment. PLoS ONE. 2013
  988. UTP Transactivates Epidermal Growth Factor Receptors and Promotes Cardiomyocyte Hypertrophy Despite Inhibiting Transcription of the Hypertrophic Marker Gene, Atrial Natriuretic Peptide. The Journal of Biological Chemistry. 2004
  989. Vascular Endothelial Growth Factor Induction of the Angiogenic Phenotype Requires Ras Activation. The Journal of Biological Chemistry. 2001
  990. Vascular Endothelial Growth Factor-mediated Induction of Manganese Superoxide Dismutase Occurs through Redox-dependent Regulation of Forkhead and I%CE%BAB/NF-%CE%BAB. The Journal of Biological Chemistry. 2004
  991. Vav1 Couples T Cell Receptor to Serum Response Factor-dependent Transcription via a MEK-dependent Pathway. The Journal of Biological Chemistry. 2002
  992. Vav2 Activates c-fos Serum Response Element and CD69 Expression but Negatively Regulates Nuclear Factor of Activated T Cells and Interleukin-2 Gene Activation in T Lymphocyte. The Journal of Biological Chemistry. 2001
  993. Vibrio cholerae O395 Outer Membrane Vesicles Modulate Intestinal Epithelial Cells in a NOD1 Protein-dependent Manner and Induce Dendritic Cell-mediated Th2/Th17 Cell Responses. The Journal of Biological Chemistry. 2013
  994. Vinpocetine Attenuates Neointimal Hyperplasia in Diabetic Rat Carotid Arteries after Balloon Injury. PLoS ONE. 2014
  995. Vitamin D3-induced Apoptosis of Murine Squamous Cell Carcinoma Cells:SELECTIVE INDUCTION OF CASPASE-DEPENDENT MEK CLEAVAGE AND UP-REGULATION OF MEKK-1. The Journal of Biological Chemistry. 2001
  996. v-SRC Specifically Regulates the Nucleo-cytoplasmic Delocalization of the Major Isoform of TEL (ETV6). The Journal of Biological Chemistry. 2003
  997. Wnt-7a Causes Loss of Differentiated Phenotype and Inhibits Apoptosis of Articular Chondrocytes via Different Mechanisms. The Journal of Biological Chemistry. 2004
  998. Wogonin Suppresses Melanoma Cell B16-F10 Invasion and Migration by Inhibiting Ras-Medicated Pathways. PLoS ONE. 2014
  999. Zinc-Finger Nuclease Knockout of Dual-Specificity Protein Phosphatase-5 Enhances the Myogenic Response and Autoregulation of Cerebral Blood Flow in FHH.1BN Rats. PLoS ONE. 2014
  1000. δ-Opioid Receptor and Somatostatin Receptor-4 Heterodimerization: Possible Implications in Modulation of Pain Associated Signaling. PLoS ONE. 2014

 

JAK2: Research Trend, Expert Distribution, and Antibody Citation

Janus kinase 2 (JAK2),also known as JTK10; THCYT3, is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [1-6]

Fig 1. JAK2 Research Distribution. Institutions are ranked by number of related projects.

Fig 1. JAK2 Research Distribution. Institutions are ranked by number of related projects.

Research Overview

In the past 16 years, JAK2 research has been conducted in 285 research groups from 129 institutions in the United States. The accumulated number of projects: 1,124, and funding: $ 328 million.

 

Fig 2. Research Trend of JAK2 by annual NIH project number, funding, and NIH PI.

Fig 2. Research Trend of JAK2 by annual NIH project number, funding, and NIH PI.

 

Antibody Citation

JAK2 accounts for 0.2% of all publications in the past 15 years. 26 manufacturers have produced JAK2 antibody with citations appearing in peer review publications. The top suppliers are, Santa Cruz, Cell Signaling Technology, and Upstate (now with EMD Millipore) accounting for around 90% of total citations. The annual citation trend are summarized below.

Fig 3. JAK2 Antibody Citation breakdown. Total citations from all providers from all years (2000-2014) are included.

Fig 3. JAK2 Antibody Citation breakdown. Total citations from all providers from all years (2000-2014) are included.

Fig 4

Fig 4. JAK2 Antibody Citation Trend: Annual product citation trend from each provider.

 

Closing Remarks:

This snapshot features a quantitative analysis for JAK2 research, and a cross-vendor comparison for JAK2 antibody manufacturers. It is aimed to provide a top-down perspective to deepen our understanding for JAK2; and an unbiased comparison for rational selection of JAK2 antibody. The complete list of publications found with JAK2 antibody citation from major open source publications can be viewed in JAK2 antibody comparison module.

 

Reference:

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  3. Molecular insights into regulation of JAK2 in myeloproliferative neoplasms. Silvennoinen O, et al. Blood, 2015
  4. Mutations and long-term outcome of 217 young patients with essential thrombocythemia or early primary myelofibrosis. Palandri F, et al. Leukemia, 2015
  5. Diagnostic value of the JAK2 V617F mutation for latent chronic myeloproliferative disorders in patients with Budd-Chiari syndrome and/or portal vein thrombosis. Karak?se S, et al. Turk J Gastroenterol, 2015
  6. Recurrent coronary arterial thromboses as the tip of the iceberg: the JAK2 mutation-related disease. Yang M, et al. Int J Cardiol, 2015
  7. Tocotrienol but Not %CE%B3-Tocopherol Blocks STAT3 Cell Signaling Pathway through Induction of Protein-tyrosine Phosphatase SHP-1 and Sensitizes Tumor Cells to Chemotherapeutic Agents. The Journal of Biological Chemistry. 2010
  8. Dihydroxyvitamin D3 Inhibits GH-induced Expression of SOCS-3 and CIS and Prolongs Growth Hormone Signaling via the Janus Kinase (JAK2)/Signal Transducers and Activators of Transcription (STAT5) System in Osteoblast-like Cells. The Journal of Biological Chemistry. 2002
  9. 15-Lipoxygenase-1-enhanced Src-Janus Kinase 2-Signal Transducer and Activator of Transcription 3 Stimulation and Monocyte Chemoattractant Protein-1 Expression Require Redox-sensitive Activation of Epidermal Growth Factor Receptor in Vascular Wall Remodeling. The Journal of Biological Chemistry. 2011
  10. 5(S)-Hydroxyeicosatetraenoic Acid Stimulates DNA Synthesis in Human Microvascular Endothelial Cells via Activation of Jak/STAT and Phosphatidylinositol 3-Kinase/Akt Signaling, Leading to Induction of Expression of Basic Fibroblast Growth Factor 2. The Journal of Biological Chemistry. 2002
  11. 8p12 Stem Cell Myeloproliferative Disorder: the FOP-Fibroblast Growth Factor Receptor 1 Fusion Protein of the t(6;8) Translocation Induces Cell Survival Mediated by Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase/Akt/mTOR Pathways. Molecular and Cellular Biology. 2001
  12. A completely foreign receptor can mediate an interferon-[gamma]-like response. The EMBO Journal. 2001
  13. A Functional Green Fluorescent Protein-tagged Erythropoietin Receptor Despite Physical Separation of JAK2 Binding Site and Tyrosine Residues. The Journal of Biological Chemistry. 2002
  14. A JAK2 Interdomain Linker Relays Epo Receptor Engagement Signals to Kinase Activation. The Journal of Biological Chemistry. 2009
  15. A Mutant Form of JAB/SOCS1 Augments the Cytokine-induced JAK/STAT Pathway by Accelerating Degradation of Wild-type JAB/CIS Family Proteins through the SOCS-box. The Journal of Biological Chemistry. 2001
  16. A Mutant Stat5b with Weaker DNA Binding Affinity Defines a Key Defective Pathway in Nonobese Diabetic Mice. The Journal of Biological Chemistry. 2004
  17. A Novel Function for a Glucose Analog of Blood Group H Antigen as a Mediator of Leukocyte-Endothelial Adhesion via Intracellular Adhesion Molecule 1. The Journal of Biological Chemistry. 2003
  18. A Novel Mechanism for JAK2 Activation by a G Protein-coupled Receptor, the CCK2R:IMPLICATION OF THIS SIGNALING PATHWAY IN PANCREATIC TUMOR MODELS. The Journal of Biological Chemistry. 2005
  19. A Polymeric Nanomedicine Diminishes Inflammatory Events in Renal Tubular Cells. PLoS ONE. 2013
  20. A Polymeric Nanomedicine Diminishes Inflammatory Events in Renal Tubular Cells. PLoS ONE. 2012
  21. A Structure-Function Analysis of Serine/Threonine Phosphorylation of the Thrombopoietin Receptor, c-Mpl. The Journal of Biological Chemistry. 2000
  22. Aciculatin Inhibits Granulocyte Colony-Stimulating Factor Production by Human Interleukin 1β-Stimulated Fibroblast-Like Synoviocytes. PLoS ONE. 2012
  23. Activated Jak2 with the V617F Point Mutation Promotes G1/S Phase Transition. The Journal of Biological Chemistry. 2006
  24. Activation of JAK2-V617F by Components of Heterodimeric Cytokine Receptors. The Journal of Biological Chemistry. 2010
  25. Activation of MAPKs by Angiotensin II in Vascular Smooth Muscle Cells:METALLOPROTEASE-DEPENDENT EGF RECEPTOR ACTIVATION IS REQUIRED FOR ACTIVATION OF ERK AND p38 MAPK BUT NOT FOR JNK. The Journal of Biological Chemistry. 2001
  26. Activation of Stat3 by Heregulin/ErbB-2 through the Co-Option of Progesterone Receptor Signaling Drives Breast Cancer Growth. Molecular and Cellular Biology. 2009
  27. Activation of the Leptin Receptor by a Ligand-induced Conformational Change of Constitutive Receptor Dimers. The Journal of Biological Chemistry. 2003
  28. Activation of the Mitogen-activated Protein Kinases Erk1/2 by Erythropoietin Receptor via a Gi Protein %CE%B2%CE%B3-Subunit-initiated Pathway. The Journal of Biological Chemistry. 2003
  29. Active Conformation of the Erythropoietin Receptor:RANDOM AND CYSTEINE-SCANNING MUTAGENESIS OF THE EXTRACELLULAR JUXTAMEMBRANE AND TRANSMEMBRANE DOMAINS. The Journal of Biological Chemistry. 2006
  30. Adiponectin and Leptin Induce VCAM-1 Expression in Human and Murine Chondrocytes. PLoS ONE. 2012
  31. ALK-Activating Homologous Mutations in LTK Induce Cellular Transformation. PLoS ONE. 2012
  32. Alternative Activation of STAT1 and STAT3 in Response to Interferon-%CE%B3. The Journal of Biological Chemistry. 2004
  33. An Amphipathic Helical Region of the N-terminal Barrel of Phospholipid Transfer Protein Is Critical for ABCA1-dependent Cholesterol Efflux. The Journal of Biological Chemistry. 2008
  34. An Essential Role of the Jak-2/STAT-3/Cytosolic Phospholipase A2 Axis in Platelet-derived Growth Factor BB-induced Vascular Smooth Muscle Cell Motility. The Journal of Biological Chemistry. 2004
  35. Analysis of Jak2 Catalytic Function by Peptide Microarrays: The Role of the JH2 Domain and V617F Mutation. PLoS ONE. 2011
  36. Anti-Inflammation of Spirocyclopiperazinium Salt Compound LXM-10 Targeting α7 nAChR and M4 mAChR and Inhibiting JAK2/STAT3 Pathway in Rats. PLoS ONE. 2013
  37. Antitumor Activity of a Novel Oncrasin Analogue Is Mediated by JNK Activation and STAT3 Inhibition. PLoS ONE. 2011
  38. Arginine-Vasopressin Activates the JAK-STAT Pathway in Vascular Smooth Muscle Cells. The Journal of Biological Chemistry. 2006
  39. Astaxanthin Inhibits JAK/STAT-3 Signaling to Abrogate Cell Proliferation, Invasion and Angiogenesis in a Hamster Model of Oral Cancer. PLoS ONE. 2014
  40. ATP Mediates NADPH Oxidase/ROS Generation and COX-2/PGE2 Expression in A549 Cells: Role of P2 Receptor-Dependent STAT3 Activation. PLoS ONE. 2013
  41. ATP Mediates NADPH Oxidase/ROS Generation and COX-2/PGE2 Expression in A549 Cells: Role of P2 Receptor-Dependent STAT3 Activation. PLoS ONE. 2012
  42. Autocrine-mediated Activation of STAT3 Correlates with Cell Proliferation in Breast Carcinoma Lines. The Journal of Biological Chemistry. 2002
  43. Autoinhibition of Jak2 Tyrosine Kinase Is Dependent on Specific Regions in Its Pseudokinase Domain. Molecular Biology of the Cell. 2003
  44. Autophagy Facilitates IFN-%CE%B3-induced Jak2-STAT1 Activation and Cellular Inflammation. The Journal of Biological Chemistry. 2010
  45. Autophosphorylation of JAK2 on Tyrosines 221 and 570 Regulates Its Activity. Molecular and Cellular Biology. 2004
  46. BCR-ABL Affects STAT5A and STAT5B Differentially. PLoS ONE. 2014
  47. Binding of SH2-B Family Members within a Potential Negative Regulatory Region Maintains JAK2 in an Active State. Molecular and Cellular Biology. 2006
  48. Blocking HIV-1 infection via CCR5 and CXCR4 receptors by acting in : trans: on the CCR2 chemokine receptor. The EMBO Journal. 2004
  49. Box 2 Region of the Oncostatin M Receptor Determines Specificity for Recruitment of Janus Kinases and STAT5 Activation. The Journal of Biological Chemistry. 2008
  50. Bradykinin B2 Receptors Activate Na+/H+ Exchange in mIMCD-3 Cells via Janus Kinase 2 and Ca2+/Calmodulin. The Journal of Biological Chemistry. 2001
  51. Brevilin A, a Novel Natural Product, Inhibits Janus Kinase Activity and Blocks STAT3 Signaling in Cancer Cells. PLoS ONE. 2013
  52. Cardiac Glycosides Induce Cell Death in Human Cells by Inhibiting General Protein Synthesis. PLoS ONE. 2009
  53. Cardiac Lineage Protein-1 (CLP-1) Regulates Cardiac Remodeling via Transcriptional Modulation of Diverse Hypertrophic and Fibrotic Responses and Angiotensin II-transforming Growth Factor %CE%B2 (TGF-%CE%B21) Signaling Axis. The Journal of Biological Chemistry. 2012
  54. Cardiotrophin-1 Induces Matrix Metalloproteinase-1 in Human Aortic Endothelial Cells. PLoS ONE. 2013
  55. Caveolar and Lipid Raft Localization of the Growth Hormone Receptor and Its Signaling Elements:IMPACT ON GROWTH HORMONE SIGNALING. The Journal of Biological Chemistry. 2004
  56. CBL Linker Region and RING Finger Mutations Lead to Enhanced Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF) Signaling via Elevated Levels of JAK2 and LYN. The Journal of Biological Chemistry. 2013
  57. CD69 Association with Jak3/Stat5 Proteins Regulates Th17 Cell Differentiation. Molecular and Cellular Biology. 2010
  58. Central Exercise Action Increases the AMPK and mTOR Response to Leptin. PLoS ONE. 2008
  59. CIS3/SOCS-3 Suppresses Erythropoietin (EPO) Signaling by Binding the EPO Receptor and JAK2. The Journal of Biological Chemistry. 2000
  60. Cloning and Characterization of a Family of Proteins Associated with Mpl. The Journal of Biological Chemistry. 2002
  61. Collagen I Induces Discoidin Domain Receptor (DDR) 1 Expression through DDR2 and a JAK2-ERK1/2-mediated Mechanism in Primary Human Lung Fibroblasts. The Journal of Biological Chemistry. 2011
  62. Complex Effects of Naturally Occurring Mutations in the JAK3 Pseudokinase Domain: Evidence for Interactions between the Kinase and Pseudokinase Domains. Molecular and Cellular Biology. 2000
  63. Conditional Deletion of Shp2 in the Mammary Gland Leads to Impaired Lobulo-alveolar Outgrowth and Attenuated Stat5 Activation. The Journal of Biological Chemistry. 2006
  64. Constitutive Phosphorylation of GATA-1 at Serine26 Attenuates the Colony-Forming Activity of Erythrocyte-Committed Progenitors. PLoS ONE. 2013
  65. Contribution of the Box 1 and Box 2 Motifs of Cytokine Receptors to Jak1 Association and Activation. The Journal of Biological Chemistry. 2002
  66. Coupling of Heterotrimeric Gi Proteins to the Erythropoietin Receptor. The Journal of Biological Chemistry. 2001
  67. CrkL Is Recruited through Its SH2 Domain to the Erythropoietin Receptor and Plays a Role in Lyn-mediated Receptor Signaling. The Journal of Biological Chemistry. 2001
  68. Cross Talk between Signaling and Vitamin A Transport by the Retinol-Binding Protein Receptor STRA6. Molecular and Cellular Biology. 2012
  69. Crosstalk between PKC[zeta] and the IL4/Stat6 pathway during T-cell-mediated hepatitis. The EMBO Journal. 2004
  70. Curcumin Blocks Small Cell Lung Cancer Cells Migration, Invasion, Angiogenesis, Cell Cycle and Neoplasia through Janus Kinase-STAT3 Signalling Pathway. PLoS ONE. 2012
  71. Curcumin Suppresses the Induction of Indoleamine 2,3-Dioxygenase by Blocking the Janus-activated Kinase-Protein Kinase C%CE%B4-STAT1 Signaling Pathway in Interferon-%CE%B3-stimulated Murine Dendritic Cells. The Journal of Biological Chemistry. 2009
  72. CXCL12 Signaling Is Independent of Jak2 and Jak3. The Journal of Biological Chemistry. 2005
  73. CXCR4-mediated Suppressor of Cytokine Signaling Up-regulation Inactivates Growth Hormone Function. The Journal of Biological Chemistry. 2004
  74. Cytokine Signaling through Stat3 Activates Integrins, Promotes Adhesion, and Induces Growth Arrest in the Myeloid Cell Line 32D. The Journal of Biological Chemistry. 2000
  75. Cytosolic Phospholipase A2 Is an Effector of Jak/STAT Signaling and Is Involved in Platelet-derived Growth Factor BB-induced Growth in Vascular Smooth Muscle Cells. The Journal of Biological Chemistry. 2003
  76. Deletion of Tumor Necrosis Factor-%CE%B1 Receptor 1 (TNFR1) Protects against Diet-induced Obesity by Means of Increased Thermogenesis. The Journal of Biological Chemistry. 2009
  77. Differential Regulation of STAT Family Members by Glycogen Synthase Kinase-3. The Journal of Biological Chemistry. 2008
  78. Dimerization by a Cytokine Receptor Is Necessary for Constitutive Activation of JAK2V617F. The Journal of Biological Chemistry. 2008
  79. Distinct Mechanisms of Receptor and Nonreceptor Tyrosine Kinase Activation by Reactive Oxygen Species in Vascular Smooth Muscle Cells: Role of Metalloprotease and Protein Kinase C-%CE%B4. Molecular and Cellular Biology. 2003
  80. Divergent Roles of SHP-2 in ERK Activation by Leptin Receptors. The Journal of Biological Chemistry. 2001
  81. DNA Damage Stress and Inhibition of Jak2-V617F Cause Its Degradation and Synergistically Induce Apoptosis through Activation of GSK3β. PLoS ONE. 2011
  82. Effects of a Leukemia-associated Gain-of-Function Mutation of SHP-2 Phosphatase on Interleukin-3 Signaling. The Journal of Biological Chemistry. 2006
  83. Elongin B/C Recruitment Regulates Substrate Binding by CIS. The Journal of Biological Chemistry. 2008
  84. Enu Mutagenesis Identifies a Novel Platelet Phenotype in a Loss-Of-Function Jak2 Allele. PLoS ONE. 2013
  85. Epidermal Growth Factor Stimulates RSK2 Activation through Activation of the MEK/ERK Pathway and Src-dependent Tyrosine Phosphorylation of RSK2 at Tyr-529. The Journal of Biological Chemistry. 2008
  86. Epitope Randomization Redefines the Functional Role of Glutamic Acid 110 in Interleukin-5 Receptor Activation. The Journal of Biological Chemistry. 2000
  87. Erlotinib Effectively Inhibits JAK2V617F Activity and Polycythemia Vera Cell Growth. The Journal of Biological Chemistry. 2007
  88. Erythropoietin Blockade Inhibits the Induction of Tumor Angiogenesis and Progression. PLoS ONE. 2007
  89. Erythropoietin Couples Hematopoiesis with Bone Formation. PLoS ONE. 2010
  90. Erythropoietin Protects Epithelial Cells from Excessive Autophagy and Apoptosis in Experimental Neonatal Necrotizing Enterocolitis. PLoS ONE. 2013
  91. Erythropoietin Receptor Signaling Is Membrane Raft Dependent. PLoS ONE. 2012
  92. Erythropoietin Receptor-mediated Inhibition of Exocytotic Glutamate Release Confers Neuroprotection during Chemical Ischemia. The Journal of Biological Chemistry. 2001
  93. Erythropoietin Receptors Associate with a Ubiquitin Ligase, p33RUL, and Require Its Activity for Erythropoietin-induced Proliferation. The Journal of Biological Chemistry. 2003
  94. Erythropoietin Stimulates Proliferation and Interferes with Differentiation of Myoblasts. The Journal of Biological Chemistry. 2000
  95. Essential Role for the Mnk Pathway in the Inhibitory Effects of Type I Interferons on Myeloproliferative Neoplasm (MPN) Precursors. The Journal of Biological Chemistry. 2013
  96. Etk, a Btk Family Tyrosine Kinase, Mediates Cellular Transformation by Linking Src to STAT3 Activation. Molecular and Cellular Biology. 2000
  97. Fasudil Protects the Heart against Ischemia-Reperfusion Injury by Attenuating Endoplasmic Reticulum Stress and Modulating SERCA Activity: The Differential Role for PI3K/Akt and JAK2/STAT3 Signaling Pathways. PLoS ONE. 2012
  98. Fibroblast Growth Factor 21 Is Not Required for the Reductions in Circulating Insulin-Like Growth Factor-1 or Global Cell Proliferation Rates in Response to Moderate Calorie Restriction in Adult Mice. PLoS ONE. 2014
  99. Filamins but Not Janus Kinases Are Substrates of the ASB2α Cullin-Ring E3 Ubiquitin Ligase in Hematopoietic Cells. PLoS ONE. 2012
  100. Foxo3 Is Essential for the Regulation of Ataxia Telangiectasia Mutated and Oxidative Stress-mediated Homeostasis of Hematopoietic Stem Cells. The Journal of Biological Chemistry. 2008
  101. From Macrophage Interleukin-13 Receptor to Foam Cell Formation:MECHANISMS FOR %CE%B1M%CE%B22 INTEGRIN INTERFERENCE. The Journal of Biological Chemistry. 2013
  102. Fyn Mediates Leptin Actions in the Thymus of Rodents. PLoS ONE. 2009
  103. Fyn Regulates Adipogenesis by Promoting PIKE-A/STAT5a Interaction. Molecular and Cellular Biology. 2013
  104. Glucose Enhances Leptin Signaling through Modulation of AMPK Activity. PLoS ONE. 2012
  105. G-protein-coupled Receptor Agonist BV8/Prokineticin-2 and STAT3 Protein Form a Feed-forward Loop in Both Normal and Malignant Myeloid Cells. The Journal of Biological Chemistry. 2013
  106. Growth Hormone Inhibition of Glucose Uptake in Adipocytes Occurs without Affecting GLUT4 Translocation through an Insulin Receptor Substrate-2-Phosphatidylinositol 3-Kinase-dependent Pathway. The Journal of Biological Chemistry. 2009
  107. Growth Hormone Receptor Ubiquitination, Endocytosis, and Degradation Are Independent of Signal Transduction via Janus Kinase 2. The Journal of Biological Chemistry. 2001
  108. Growth Hormone-induced Differential Desensitization of STAT5, ERK, and Akt Phosphorylation. The Journal of Biological Chemistry. 2002
  109. hCTR9, a Component of Paf1 Complex, Participates in the Transcription of Interleukin 6-responsive Genes through Regulation of STAT3-DNA Interactions. The Journal of Biological Chemistry. 2007
  110. Helicobacter pylori CagA Phosphorylation Status Determines the gp130-activated SHP2/ERK and JAK/STAT Signal Transduction Pathways in Gastric Epithelial Cells. The Journal of Biological Chemistry. 2010
  111. Hepatitis C Virus Core Protein Differently Regulates the JAK-STAT Signaling Pathway under Interleukin-6 and Interferon-%CE%B3 Stimuli. The Journal of Biological Chemistry. 2003
  112. Hepatocyte-specific Deletion of Janus Kinase 2 (JAK2) Protects against Diet-induced Steatohepatitis and Glucose Intolerance. The Journal of Biological Chemistry. 2012
  113. Homocysteine Suppresses the Expression of the Collagen Cross-linker Lysyl Oxidase Involving IL-6, Fli1, and Epigenetic DNA Methylation. The Journal of Biological Chemistry. 2011
  114. hTid-1, a Human DnaJ Protein, Modulates the Interferon Signaling Pathway. The Journal of Biological Chemistry. 2001
  115. Hyperglycemia Enhances the Proliferation of Non-Tumorigenic and Malignant Mammary Epithelial Cells through Increased leptin/IGF1R Signaling and Activation of AKT/mTOR. PLoS ONE. 2013
  116. Hypertonicity Activates Na+/H+ Exchange through Janus Kinase 2 and Calmodulin. The Journal of Biological Chemistry. 2003
  117. Icariside II Induces Apoptosis in U937 Acute Myeloid Leukemia Cells: Role of Inactivation of STAT3-Related Signaling. PLoS ONE. 2011
  118. Icaritin Inhibits JAK/STAT3 Signaling and Growth of Renal Cell Carcinoma. PLoS ONE. 2013
  119. Icaritin Shows Potent Anti-Leukemia Activity on Chronic Myeloid Leukemia In Vitro and In Vivo by Regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT Signalings. PLoS ONE. 2011
  120. Identification of a JAK2-independent Pathway Regulating Growth Hormone (GH)-stimulated p44/42 Mitogen-activated Protein Kinase Activity:GH ACTIVATION OF Ral AND PHOSPHOLIPASE D IS Src-DEPENDENT. The Journal of Biological Chemistry. 2002
  121. Identification of an Acquired JAK2 Mutation in Polycythemia Vera. The Journal of Biological Chemistry. 2005
  122. Identification of JAK2 as a Mediator of FIP1L1-PDGFRA-Induced Eosinophil Growth and Function in CEL. PLoS ONE. 2012
  123. Identification of KMU-3, a Novel Derivative of Gallic Acid, as an Inhibitor of Adipogenesis. PLoS ONE. 2014
  124. Identification of Pro-Inflammatory Cytokines Associated with Muscle Invasive Bladder Cancer; The Roles of IL-5, IL-20, and IL-28A. PLoS ONE. 2012
  125. Identification of the Cytoplasmic Domains of CXCR4 Involved in Jak2 and STAT3 Phosphorylation. The Journal of Biological Chemistry. 2005
  126. Identification of the Jak/Stat Proteins as Novel Downstream Targets of EphA4 Signaling in Muscle:IMPLICATIONS IN THE REGULATION OF ACETYLCHOLINESTERASE EXPRESSION. The Journal of Biological Chemistry. 2004
  127. Identification of Transforming Hepatitis B Virus S Gene Nonsense Mutations Derived from Freely Replicative Viruses in Hepatocellular Carcinoma. PLoS ONE. 2014
  128. IL-6 Induced STAT3 Signalling Is Associated with the Proliferation of Human Muscle Satellite Cells Following Acute Muscle Damage. PLoS ONE. 2011
  129. Impaired Alveologenesis and Maintenance of Secretory Mammary Epithelial Cells in Jak2 Conditional Knockout Mice. Molecular and Cellular Biology. 2004
  130. In Vivo Analysis of Growth Hormone Receptor Signaling Domains and Their Associated Transcripts. Molecular and Cellular Biology. 2005
  131. Increased Myeloproliferation in Glutathione S-Transferase %CF%80-deficient Mice Is Associated with a Deregulation of JNK and Janus Kinase/STAT Pathways. The Journal of Biological Chemistry. 2004
  132. Increased Susceptibility to Dextran Sulfate Sodium Induced Colitis in the T Cell Protein Tyrosine Phosphatase Heterozygous Mouse. PLoS ONE. 2010
  133. Increased Unbound Retinol-binding Protein 4 Concentration Induces Apoptosis through Receptor-mediated Signaling. The Journal of Biological Chemistry. 2012
  134. Induction of Genes Mediating Interferon-dependent Extracellular Trap Formation during Neutrophil Differentiation. The Journal of Biological Chemistry. 2004
  135. Induction of gp130-related Cytokines and Activation of JAK2/STAT3 Pathway in Astrocytes Precedes Up-regulation of Glial Fibrillary Acidic Protein in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Model of Neurodegeneration:KEY SIGNALING PATHWAY FOR ASTROGLIOSIS IN VIVO?. The Journal of Biological Chemistry. 2004
  136. Inhibition of Interferon (IFN) %CE%B3-induced Jak-STAT1 Activation in Microglia by Vasoactive Intestinal Peptide:INHIBITORY EFFECT ON CD40, IFN-INDUCED PROTEIN-10, AND INDUCIBLE NITRIC-OXIDE SYNTHASE EXPRESSION. The Journal of Biological Chemistry. 2003
  137. Inhibition of STAT3 by Niclosamide Synergizes with Erlotinib against Head and Neck Cancer. PLoS ONE. 2013
  138. Inhibition of STAT3 Signaling Blocks the Anti-apoptotic Activity of IL-6 in Human Liver Cancer Cells. The Journal of Biological Chemistry. 2010
  139. Inhibition of the JAK2/STAT3 Pathway Reduces Gastric Cancer Growth In Vitro and In Vivo. PLoS ONE. 2014
  140. Inhibitory Role of the Somatostatin Receptor SST2 on the Intracrine-regulated Cell Proliferation Induced by the 210-Amino Acid Fibroblast Growth Factor-2 Isoform:IMPLICATION OF JAK2. The Journal of Biological Chemistry. 2003
  141. Insulin Enhances Growth Hormone Induction of the MEK/ERK Signaling Pathway. The Journal of Biological Chemistry. 2006
  142. Insulin Induces Suppressor of Cytokine Signaling-3 Tyrosine Phosphorylation through Janus-activated Kinase. The Journal of Biological Chemistry. 2001
  143. Insulin Reverses Growth Hormone-induced Homologous Desensitization. The Journal of Biological Chemistry. 2006
  144. Interaction of Adipocyte Fatty Acid-binding Protein (AFABP) and JAK2:AFABP/aP2 AS A REGULATOR OF JAK2 SIGNALING. The Journal of Biological Chemistry. 2009
  145. Interferon %CE%B3 Attenuates Insulin Signaling, Lipid Storage, and Differentiation in Human Adipocytes via Activation of the JAK/STAT Pathway. The Journal of Biological Chemistry. 2009
  146. Interferon-%CE%B3 Induces X-linked Inhibitor of Apoptosis-associated Factor-1 and Noxa Expression and Potentiates Human Vascular Smooth Muscle Cell Apoptosis by STAT3 Activation. The Journal of Biological Chemistry. 2008
  147. Interferon-γ Induces Senescence in Normal Human Melanocytes. PLoS ONE. 2014
  148. Interleukin-15 Induces Rapid Tyrosine Phosphorylation of STAT6 and the Expression of Interleukin-4 in Mouse Mast Cells. The Journal of Biological Chemistry. 2000
  149. Interleukin-20 Promotes Migration of Bladder Cancer Cells through Extracellular Signal-regulated Kinase (ERK)-mediated MMP-9 Protein Expression Leading to Nuclear Factor (NF-%CE%BAB) Activation by Inducing the Up-regulation of p21WAF1 Protein Expression. The Journal of Biological Chemistry. 2013
  150. Interleukin-22 (IL-22) Activates the JAK/STAT, ERK, JNK, and p38 MAP Kinase Pathways in a Rat Hepatoma Cell Line:PATHWAYS THAT ARE SHARED WITH AND DISTINCT FROM IL-10. The Journal of Biological Chemistry. 2002
  151. Intramolecular Disulfide Bonds of the Prolactin Receptor Short Form Are Required for Its Inhibitory Action on the Function of the Long Form of the Receptor. Molecular and Cellular Biology. 2009
  152. Involvement of Grb2 Adaptor Protein in Nucleophosmin-Anaplastic Lymphoma Kinase (NPM-ALK)-mediated Signaling and Anaplastic Large Cell Lymphoma Growth. The Journal of Biological Chemistry. 2010
  153. JAK/STAT but Not ERK1/ERK2 Pathway Mediates Interleukin (IL)-6/Soluble IL-6R Down-regulation of Type II Collagen, Aggrecan Core, and Link Protein Transcription in Articular Chondrocytes:ASSOCIATION WITH A DOWN-REGULATION OF SOX9 EXPRESSION. The Journal of Biological Chemistry. 2003
  154. JAK/STAT3 Pathway Is Involved in Survival of Neurons in Response to Insulin-like Growth Factor and Negatively Regulated by Suppressor of Cytokine Signaling-3. The Journal of Biological Chemistry. 2005
  155. JAK1 and Tyk2 Activation by the Homologous Polycythemia Vera JAK2 V617F Mutation:CROSS-TALK WITH IGF1 RECEPTOR. The Journal of Biological Chemistry. 2005
  156. Jak2 Acts as Both a STAT1 Kinase and as a Molecular Bridge Linking STAT1 to the Angiotensin II AT1 Receptor. The Journal of Biological Chemistry. 2000
  157. JAK2 Exon 14 Deletion in Patients with Chronic Myeloproliferative Neoplasms. PLoS ONE. 2010
  158. Jak2 FERM Domain Interaction with the Erythropoietin Receptor Regulates Jak2 Kinase Activity. Molecular and Cellular Biology. 2008
  159. Jak2 Is a Negative Regulator of Ubiquitin-Dependent Endocytosis of the Growth Hormone Receptor. PLoS ONE. 2010
  160. Jak2 Tyrosine Kinase Mediates Angiotensin II-dependent Inactivation of ERK2 via Induction of Mitogen-activated Protein Kinase Phosphatase 1. The Journal of Biological Chemistry. 2004
  161. Jak2 Tyrosine Kinase Mediates Oxidative Stress-induced Apoptosis in Vascular Smooth Muscle Cells. The Journal of Biological Chemistry. 2004
  162. JAK2 Tyrosine Kinase Phosphorylates PAK1 and Regulates PAK1 Activity and Functions. The Journal of Biological Chemistry. 2007
  163. JAK2 V617F Constitutive Activation Requires JH2 Residue F595: A Pseudokinase Domain Target for Specific Inhibitors. PLoS ONE. 2010
  164. JAK2 V617F-Dependent Upregulation of PU.1 Expression in the Peripheral Blood of Myeloproliferative Neoplasm Patients. PLoS ONE. 2011
  165. Janus Kinase (Jak) Subcellular Localization Revisited:THE EXCLUSIVE MEMBRANE LOCALIZATION OF ENDOGENOUS JANUS KINASE 1 BY CYTOKINE RECEPTOR INTERACTION UNCOVERS THE Jak%C2%B7RECEPTOR COMPLEX TO BE EQUIVALENT TO A RECEPTOR TYROSINE KINASE. The Journal of Biological Chemistry. 2004
  166. Janus Kinase 2 and Calcium Are Required for Angiotensin II-dependent Activation of Steroidogenic Acute Regulatory Protein Transcription in H295R Human Adrenocortical Cells. The Journal of Biological Chemistry. 2003
  167. Janus Kinase 2 Modulates the Apolipoprotein Interactions with ABCA1 Required for Removing Cellular Cholesterol. The Journal of Biological Chemistry. 2004
  168. Janus Kinases Affect Thrombopoietin Receptor Cell Surface Localization and Stability. The Journal of Biological Chemistry. 2005
  169. Kinase Activation through Dimerization by Human SH2-B. Molecular and Cellular Biology. 2005
  170. Leptin Increases Axonal Growth Cone Size in Developing Mouse Cortical Neurons by Convergent Signals Inactivating Glycogen Synthase Kinase-3%CE%B2. The Journal of Biological Chemistry. 2006
  171. Leptin Induces CD40 Expression through the Activation of Akt in Murine Dendritic Cells. The Journal of Biological Chemistry. 2007
  172. Leptin Receptor (Lepr) Is a Negative Modulator of Bone Mechanosensitivity and Genetic Variations in Lepr May Contribute to the Differential Osteogenic Response to Mechanical Stimulation in the C57BL/6J and C3H/HeJ Pair of Mouse Strains. The Journal of Biological Chemistry. 2010
  173. Leptin Receptor Activation Depends on Critical Cysteine Residues in Its Fibronectin Type III Subdomains. The Journal of Biological Chemistry. 2005
  174. Leptin Stimulates Both JAK2-dependent and JAK2-independent Signaling Pathways. The Journal of Biological Chemistry. 2008
  175. Leptin Stimulates Tissue Inhibitor of Metalloproteinase-1 in Human Hepatic Stellate Cells:RESPECTIVE ROLES OF THE JAK/STAT AND JAK-MEDIATED H2O2-DEPENDENT MAPK PATHWAYS. The Journal of Biological Chemistry. 2004
  176. Lestaurtinib Inhibition of the JAK/STAT Signaling Pathway in Hodgkin Lymphoma Inhibits Proliferation and Induces Apoptosis. PLoS ONE. 2011
  177. Leukocyte Antigen-related Protein Tyrosine Phosphatase Negatively Regulates Hydrogen Peroxide-induced Vascular Smooth Muscle Cell Apoptosis. The Journal of Biological Chemistry. 2008
  178. Ligand-independent Thrombopoietin Mutant Receptor Requires Cell Surface Localization for Endogenous Activity. The Journal of Biological Chemistry. 2009
  179. Mapping the Homodimer Interface of an Optimized, Artificial, Transmembrane Protein Activator of the Human Erythropoietin Receptor. PLoS ONE. 2014
  180. Mechanism of STAT3 Activation by Insulin-like Growth Factor I Receptor. The Journal of Biological Chemistry. 2000
  181. Mechanisms of SOCS3 Phosphorylation upon Interleukin-6 Stimulation:CONTRIBUTIONS OF Src- AND RECEPTOR-TYROSINE KINASES. The Journal of Biological Chemistry. 2005
  182. Modulation of Host Cell Gene Expression through Activation of STAT Transcription Factors by Pasteurella multocida Toxin. The Journal of Biological Chemistry. 2007
  183. Modulation of the Interleukin-6 Receptor Subunit Glycoprotein 130 Complex and Its Signaling by LMO4 Interaction. The Journal of Biological Chemistry. 2005
  184. Molecular Pathogenesis and Therapy of Polycythemia Induced in Mice by JAK2 V617F. PLoS ONE. 2007
  185. Monocyte Chemoattractant Protein-1 Expression Is Enhanced by Granulocyte-Macrophage Colony-stimulating Factor via Jak2-Stat5 Signaling and Inhibited by Atorvastatin in Human Monocytic U937 Cells. The Journal of Biological Chemistry. 2008
  186. MSM Enhances GH Signaling via the Jak2/STAT5b Pathway in Osteoblast-Like Cells and Osteoblast Differentiation through the Activation of STAT5b in MSCs. PLoS ONE. 2012
  187. mTOR Inhibitors Alone and in Combination with JAK2 Inhibitors Effectively Inhibit Cells of Myeloproliferative Neoplasms. PLoS ONE. 2013
  188. mTOR Inhibitors Alone and in Combination with JAK2 Inhibitors Effectively Inhibit Cells of Myeloproliferative Neoplasms. PLoS ONE. 2012
  189. Mutual Regulation of Protein-tyrosine Phosphatase 20 and Protein-tyrosine Kinase Tec Activities by Tyrosine Phosphorylation and Dephosphorylation. The Journal of Biological Chemistry. 2004
  190. New Role of JAK2/STAT3 Signaling in Endothelial Cell Oxidative Stress Injury and Protective Effect of Melatonin. PLoS ONE. 2013
  191. Nuclear Jak2 and Transcription Factor NF1-C2: a Novel Mechanism of Prolactin Signaling in Mammary Epithelial Cells. Molecular and Cellular Biology. 2006
  192. Octa-Arginine Mediated Delivery of Wild-Type Lnk Protein Inhibits TPO-Induced M-MOK Megakaryoblastic Leukemic Cell Growth by Promoting Apoptosis. PLoS ONE. 2011
  193. Oncostatin M Mediates STAT3-Dependent Intestinal Epithelial Restitution via Increased Cell Proliferation, Decreased Apoptosis and Upregulation of SERPIN Family Members. PLoS ONE. 2014
  194. Phosphatidylinositol 3-Kinase p85%CE%B1 Subunit-Dependent Interaction with BCR/ABL-Related Fusion Tyrosine Kinases: Molecular Mechanisms and Biological Consequences. Molecular and Cellular Biology. 2005
  195. Phosphorylation of STAT-3 in Response to Basic Fibroblast Growth Factor Occurs through a Mechanism Involving Platelet-activating Factor, JAK-2, and Src in Human Umbilical Vein Endothelial Cells:EVIDENCE FOR A DUAL KINASE MECHANISM. The Journal of Biological Chemistry. 2002
  196. PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development. The EMBO Journal. 2010
  197. Pleckstrin Homology and Phosphotyrosine-binding Domain-dependent Membrane Association and Tyrosine Phosphorylation of Dok-4, an Inhibitory Adapter Molecule Expressed in Epithelial Cells. The Journal of Biological Chemistry. 2004
  198. Procaspase 8 and Bax Are Up-regulated by Distinct Pathways in Streptococcal Pyrogenic Exotoxin B-induced Apoptosis. The Journal of Biological Chemistry. 2009
  199. Progesterone Induction of the 11%CE%B2-Hydroxysteroid Dehydrogenase Type 2 Promoter in Breast Cancer Cells Involves Coordinated Recruitment of STAT5A and Progesterone Receptor to a Distal Enhancer and Polymerase Tracking. Molecular and Cellular Biology. 2008
  200. Progesterone Receptor Induces ErbB-2 Nuclear Translocation To Promote Breast Cancer Growth via a Novel Transcriptional Effect: ErbB-2 Function as a Coactivator of Stat3. Molecular and Cellular Biology. 2010
  201. Progestins Induce Transcriptional Activation of Signal Transducer and Activator of Transcription 3 (Stat3) via a Jak- and Src-Dependent Mechanism in Breast Cancer Cells. Molecular and Cellular Biology. 2005
  202. Prolactin-induced Cell Proliferation in PC12 Cells Depends on JNK but Not ERK Activation. The Journal of Biological Chemistry. 2000
  203. Proliferation and Survival Signaling from Both Jak2-V617F and Lyn Involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 Cell Line Newly Established from Acute Myeloid Leukemia Transformed from Polycythemia Vera. PLoS ONE. 2014
  204. Proteasomes Regulate the Duration of Erythropoietin Receptor Activation by Controlling Down-regulation of Cell Surface Receptors. The Journal of Biological Chemistry. 2000
  205. Protein Kinase C %CE%B1 Controls Erythropoietin Receptor Signaling. The Journal of Biological Chemistry. 2000
  206. Protein Tyrosine Phosphatase 1B Attenuates Growth Hormone-Mediated JAK2-STAT Signaling. Molecular and Cellular Biology. 2003
  207. Protein Tyrosine Phosphatase 1B Deficiency Ameliorates Murine Experimental Colitis via the Expansion of Myeloid-Derived Suppressor Cells. PLoS ONE. 2013
  208. Protein-tyrosine Phosphatase D1, a Potential Regulator and Effector for Tec Family Kinases. The Journal of Biological Chemistry. 2000
  209. Protein-tyrosine Phosphatase PTP%CE%B5C Inhibits Jak-STAT Signaling and Differentiation Induced by Interleukin-6 and Leukemia Inhibitory Factor in M1 Leukemia Cells. The Journal of Biological Chemistry. 2000
  210. Raft-mediated Src Homology 2 Domain-containing Proteintyrosine Phosphatase 2 (SHP-2) Regulation in Microglia. The Journal of Biological Chemistry. 2006
  211. Random Mutagenesis Reveals Residues of JAK2 Critical in Evading Inhibition by a Tyrosine Kinase Inhibitor. PLoS ONE. 2012
  212. RANTES Activates Jak2 and Jak3 to Regulate Engagement of Multiple Signaling Pathways in T Cells. The Journal of Biological Chemistry. 2001
  213. Rapid Inhibition of Leptin Signaling by Glucocorticoids in Vitro and in Vivo. The Journal of Biological Chemistry. 2004
  214. Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2. The EMBO Journal. 2006
  215. Regulation of Inducible Nitric-oxide Synthase by the SPRY Domain- and SOCS Box-containing Proteins. The Journal of Biological Chemistry. 2011
  216. Regulation of Jak2 Function by Phosphorylation of Tyr317 and Tyr637 during Cytokine Signaling. Molecular and Cellular Biology. 2009
  217. Regulation of Jak2 through the Ubiquitin-Proteasome Pathway Involves Phosphorylation of Jak2 on Y1007 and Interaction with SOCS-1. Molecular and Cellular Biology. 2002
  218. Regulation of Lymphocyte Development by Cell-Type-Specific Interpretation of Notch Signals. Molecular and Cellular Biology. 2008
  219. Regulation of Stat3 Activation by MEK Kinase 1. The Journal of Biological Chemistry. 2001
  220. Resveratrol Induces Cell Cycle Arrest and Apoptosis in Malignant NK Cells via JAK2/STAT3 Pathway Inhibition. PLoS ONE. 2013
  221. Resveratrol Induces Cell Cycle Arrest and Apoptosis in Malignant NK Cells via JAK2/STAT3 Pathway Inhibition. PLoS ONE. 2012
  222. Rho Family GTPases Are Required for Activation of Jak/STAT Signaling by G Protein-Coupled Receptors. Molecular and Cellular Biology. 2003
  223. RhoA/ROCK Activation by Growth Hormone Abrogates p300/Histone Deacetylase 6 Repression of Stat5-mediated Transcription. The Journal of Biological Chemistry. 2004
  224. Role of Kr%C3%BCppel-Like Factor 4 in Neurogenesis and Radial Neuronal Migration in the Developing Cerebral Cortex. Molecular and Cellular Biology. 2012
  225. Role of the Distal Half of the c-Mpl Intracellular Domain in Control of Platelet Production by Thrombopoietin In Vivo. Molecular and Cellular Biology. 2000
  226. Role of the JAK/STAT Pathway in the Regulation of Interleukin-8 Transcription by Oxidized Phospholipids in Vitro and in Atherosclerosis in Vivo. The Journal of Biological Chemistry. 2007
  227. Role of Tyrosine 441 of Interferon-%CE%B3 Receptor Subunit 1 in SOCS-1-mediated Attenuation of STAT1 Activation. The Journal of Biological Chemistry. 2005
  228. Role of Tyrosine Kinase Jak2 in Prolactin-induced Differentiation and Growth of Mammary Epithelial Cells. The Journal of Biological Chemistry. 2002
  229. Scoparone Exerts Anti-Tumor Activity against DU145 Prostate Cancer Cells via Inhibition of STAT3 Activity. PLoS ONE. 2013
  230. SHP-2 Regulates SOCS-1-mediated Janus Kinase-2 Ubiquitination/Degradation Downstream of the Prolactin Receptor. The Journal of Biological Chemistry. 2003
  231. Signal Regulatory Protein %CE%B1 Ligation Induces Macrophage Nitric Oxide Production through JAK/STAT- and Phosphatidylinositol 3-Kinase/Rac1/NAPDH Oxidase/H2O2-Dependent Pathways. Molecular and Cellular Biology. 2005
  232. Signaling Pathways Recruited by the Cardiotrophin-like Cytokine/Cytokine-like Factor-1 Composite Cytokine:SPECIFIC REQUIREMENT OF THE MEMBRANE-BOUND FORM OF CILIARY NEUROTROPHIC FACTOR RECEPTOR %CE%B1 COMPONENT. The Journal of Biological Chemistry. 2001
  233. Simvastatin Impairs Growth Hormone-Activated Signal Transducer and Activator of Transcription (STAT) Signaling Pathway in UMR-106 Osteosarcoma Cells. PLoS ONE. 2014
  234. Simvastatin Inhibits Renal Cancer Cell Growth and Metastasis via AKT/mTOR, ERK and JAK2/STAT3 Pathway. PLoS ONE. 2013
  235. Smad Signaling Antagonizes STAT5-mediated Gene Transcription and Mammary Epithelial Cell Differentiation. The Journal of Biological Chemistry. 2008
  236. Small Compound 6-O-Angeloylplenolin Induces Mitotic Arrest and Exhibits Therapeutic Potentials in Multiple Myeloma. PLoS ONE. 2011
  237. S-Nitrosoglutathione Induces Ciliary Neurotrophic Factor Expression in Astrocytes, Which Has Implications to Protect the Central Nervous System under Pathological Conditions. The Journal of Biological Chemistry. 2013
  238. Socs-1 Inhibits TEL-JAK2-Mediated Transformation of Hematopoietic Cells through Inhibition of JAK2 Kinase Activity and Induction of Proteasome-Mediated Degradation. Molecular and Cellular Biology. 2001
  239. Sorafenib Sensitizes Solid Tumors to Apo2L/TRAIL and Apo2L/TRAIL Receptor Agonist Antibodies by the Jak2-Stat3-Mcl1 Axis. PLoS ONE. 2013
  240. Specific Inhibition of Interferon Signal Transduction Pathways by Adenoviral Infection. The Journal of Biological Chemistry. 2001
  241. Spirooxindole Derivative SOID-8 Induces Apoptosis Associated with Inhibition of JAK2/STAT3 Signaling in Melanoma Cells. PLoS ONE. 2012
  242. Src Family Kinases Are Required for Prolactin Induction of Cell Proliferation. Molecular Biology of the Cell. 2001
  243. Src Kinases Mediate STAT Growth Pathways in Squamous Cell Carcinoma of the Head and Neck. The Journal of Biological Chemistry. 2003
  244. STAT3 Is Activated by JAK2 Independent of Key Oncogenic Driver Mutations in Non-Small Cell Lung Carcinoma. PLoS ONE. 2012
  245. Stat3 Is Required for Full Neoplastic Transformation by the Simian Virus 40 Large Tumor Antigen. Molecular Biology of the Cell. 2005
  246. STAT3 Regulates MMP3 in Heme-Induced Endothelial Cell Apoptosis. PLoS ONE. 2013
  247. STAT4 Requires the N-terminal Domain for Efficient Phosphorylation. The Journal of Biological Chemistry. 2003
  248. STAT5 Activation Is Critical for the Transformation Mediated by Myeloproliferative Disorder-associated JAK2 V617F Mutant. The Journal of Biological Chemistry. 2010
  249. Studies with Chimeric Mpl/JAK2 Receptors Indicate That Both JAK2 and the Membrane-proximal Domain of Mpl Are Required for Cellular Proliferation. The Journal of Biological Chemistry. 2002
  250. Substitution of Pseudokinase Domain Residue Val-617 by Large Non-polar Amino Acids Causes Activation of JAK2. The Journal of Biological Chemistry. 2008
  251. Suppression of Apoptosis Induced by Growth Factor Withdrawal by an Oncogenic Form of c-Cbl. The Journal of Biological Chemistry. 2001
  252. Suppression of JAK2/STAT3 Signaling Reduces End-to-End Arterial Anastomosis Induced Cell Proliferation in Common Carotid Arteries of Rats. PLoS ONE. 2013
  253. Suppressor of Cytokine Signaling 1 Regulates an Endogenous Inhibitor of a Mast Cell Protease. The Journal of Biological Chemistry. 2003
  254. Suppressor of Cytokine Signalling-6 Promotes Neurite Outgrowth via JAK2/STAT5-Mediated Signalling Pathway, Involving Negative Feedback Inhibition. PLoS ONE. 2011
  255. Targeting CD44-STAT3 Signaling by Gemini Vitamin D Analog Leads to Inhibition of Invasion in Basal-Like Breast Cancer. PLoS ONE. 2013
  256. Targeting CD44-STAT3 Signaling by Gemini Vitamin D Analog Leads to Inhibition of Invasion in Basal-Like Breast Cancer. PLoS ONE. 2012
  257. Targeting Energy Metabolic and Oncogenic Signaling Pathways in Triple-negative Breast Cancer by a Novel Adenosine Monophosphate-activated Protein Kinase (AMPK) Activator. The Journal of Biological Chemistry. 2011
  258. The Acute Lymphoblastic Leukemia-associated JAK2 L611S Mutant Induces Tumorigenesis in Nude Mice. The Journal of Biological Chemistry. 2009
  259. The Angiotensin II-dependent Nuclear Translocation of Stat1 Is Mediated by the Jak2 Protein Motif231YRFRR. The Journal of Biological Chemistry. 2001
  260. The CXCR4 Antagonist AMD3465 Regulates Oncogenic Signaling and Invasiveness In Vitro and Prevents Breast Cancer Growth and Metastasis In Vivo. PLoS ONE. 2013
  261. The Fanconi Anemia Protein FANCC Binds to and Facilitates the Activation of STAT1 by Gamma Interferon and Hematopoietic Growth Factors. Molecular and Cellular Biology. 2000
  262. The Heat Shock Protein 90-CDC37 Chaperone Complex Is Required for Signaling by Types I and II Interferons. The Journal of Biological Chemistry. 2006
  263. The Induction of APC with a Distinct Tolerogenic Phenotype via Contact-Dependent STAT3 Activation. PLoS ONE. 2009
  264. The Inhibition of N-Glycosylation of Glycoprotein 130 Molecule Abolishes STAT3 Activation by IL-6 Family Cytokines in Cultured Cardiac Myocytes. PLoS ONE. 2014
  265. The Interleukin 3 Gene (IL3) Contributes to Human Brain Volume Variation by Regulating Proliferation and Survival of Neural Progenitors. PLoS ONE. 2012
  266. The Jak/Stat Signaling Pathway Is Downregulated at Febrile Temperatures. PLoS ONE. 2012
  267. The Jak2 Small Molecule Inhibitor, G6, Reduces the Tumorigenic Potential of T98G Glioblastoma Cells In Vitro and In Vivo. PLoS ONE. 2014
  268. The Macrophage Cholesterol Exporter ABCA1 Functions as an Anti-inflammatory Receptor. The Journal of Biological Chemistry. 2009
  269. The Membrane-proximal Region of the Thrombopoietin Receptor Confers Its High Surface Expression by JAK2-dependent and -independent Mechanisms. The Journal of Biological Chemistry. 2006
  270. The Pseudokinase Domain Is Required for Suppression of Basal Activity of Jak2 and Jak3 Tyrosine Kinases and for Cytokine-inducible Activation of Signal Transduction. The Journal of Biological Chemistry. 2002
  271. The Role of Disulfide-linked Dimerization in Interleukin-3 Receptor Signaling and Biological Activity. The Journal of Biological Chemistry. 2000
  272. The Signal Transduction of the Growth Hormone Receptor Is Regulated by the Ubiquitin/Proteasome System and Continues After Endocytosis. The Journal of Biological Chemistry. 2001
  273. The STRA6 Receptor Is Essential for Retinol-binding Protein-induced Insulin Resistance but Not for Maintaining Vitamin A Homeostasis in Tissues Other Than the Eye. The Journal of Biological Chemistry. 2013
  274. The Synthetic α-Bromo-2′,3,4,4′-Tetramethoxychalcone (α-Br-TMC) Inhibits the JAK/STAT Signaling Pathway. PLoS ONE. 2014
  275. Thrombin Inhibits Tumor Cell Growth in Association with Up-regulation of p21 waf/cip1 and Caspases via a p53-independent, STAT-1-dependent Pathway. The Journal of Biological Chemistry. 2000
  276. Thrombin Regulates Vascular Smooth Muscle Cell Growth and Heat Shock Proteins via the JAK-STAT Pathway. The Journal of Biological Chemistry. 2001
  277. Thrombopoietin Regulates Bcl-xL Gene Expression through Stat5 and Phosphatidylinositol 3-Kinase Activation Pathways. The Journal of Biological Chemistry. 2002
  278. Toxin-induced RhoA Activity Mediates CCL1-triggered Signal Transducers and Activators of Transcription Protein Signaling. The Journal of Biological Chemistry. 2012
  279. Transcriptional Control of Adrenal Steroidogenesis:NOVEL CONNECTION BETWEEN JANUS KINASE (JAK) 2 PROTEIN AND PROTEIN KINASE A (PKA) THROUGH STABILIZATION OF cAMP RESPONSE ELEMENT-BINDING PROTEIN (CREB) TRANSCRIPTION FACTOR. The Journal of Biological Chemistry. 2011
  280. Transthyretin Blocks Retinol Uptake and Cell Signaling by the Holo-Retinol-Binding Protein Receptor STRA6. Molecular and Cellular Biology. 2012
  281. Tristetraprolin-dependent Post-transcriptional Regulation of Inflammatory Cytokine mRNA Expression by Apolipoprotein A-I:ROLE OF ATP-BINDING MEMBRANE CASSETTE TRANSPORTER A1 AND SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3. The Journal of Biological Chemistry. 2011
  282. Tumour Necrosis Factor Alpha, Interferon Gamma and Substance P Are Novel Modulators of Extrapituitary Prolactin Expression in Human Skin. PLoS ONE. 2013
  283. Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation. The Journal of Biological Chemistry. 2010
  284. Two Modes of %CE%B2-Receptor Recognition Are Mediated by Distinct Epitopes on Mouse and Human Interleukin-3. The Journal of Biological Chemistry. 2010
  285. TYK2 and JAK2 Are Substrates of Protein-tyrosine Phosphatase 1B. The Journal of Biological Chemistry. 2001
  286. Tyrosine 813 Is a Site of JAK2 Autophosphorylation Critical for Activation of JAK2 by SH2-B%CE%B2. Molecular and Cellular Biology. 2004
  287. Tyrosine Kinase Activation by the Angiotensin II Receptor in the Absence of Calcium Signaling. The Journal of Biological Chemistry. 2001
  288. Tyrosine Phosphorylation of Grb2: Role in Prolactin/Epidermal Growth Factor Cross Talk in Mammary Epithelial Cell Growth and Differentiation. Molecular and Cellular Biology. 2009
  289. Tyrosine Phosphorylation of Jak2 in the JH2 Domain Inhibits Cytokine Signaling. Molecular and Cellular Biology. 2004
  290. Tyrosine Phosphorylation of Lactate Dehydrogenase A Is Important for NADH/NAD+ Redox Homeostasis in Cancer Cells. Molecular and Cellular Biology. 2011
  291. Ubiquitination Regulates the Internalization, Endolysosomal Sorting, and Signaling of the Erythropoietin Receptor. The Journal of Biological Chemistry. 2011
  292. Up-regulation of Endothelial Nitric-oxide Synthase Promoter by the Phosphatidylinositol 3-Kinase %CE%B3/Janus Kinase 2/MEK-1-dependent Pathway. The Journal of Biological Chemistry. 2001
  293. Upregulation of Tissue Factor by Activated Stat3 Contributes to Malignant Pleural Effusion Generation via Enhancing Tumor Metastasis and Vascular Permeability in Lung Adenocarcinoma. PLoS ONE. 2013
  294. Vascular Endothelial Growth Factor Activates STAT Proteins in Aortic Endothelial Cells. The Journal of Biological Chemistry. 2000
  295. Wedelolactone, a Naturally Occurring Coumestan, Enhances Interferon-%CE%B3 Signaling through Inhibiting STAT1 Protein Dephosphorylation. The Journal of Biological Chemistry. 2013